A Study of Aticaprant Plus an Antidepressant to Prevent Return of Depression Symptoms in Participants With Major Depressive Disorder Who Experience a Loss of Interest and Pleasure
Public ClinicalTrials.gov record NCT06635135. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Double-blind, Multicenter, Placebo-controlled Study of Adjunctive Aticaprant Plus an Antidepressant for Relapse Prevention in Major Depressive Disorder (MDD) With Moderate-to-severe Anhedonia
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to assess how well aticaprant works compared to placebo when given in addition to antidepressant therapy (selective serotonin reuptake inhibitor \[SSRI\] or serotonin-norepinephrine reuptake inhibitor \[SNRI\]) in preventing return of depression symptoms in participants with major depressive disorder who experience a loss of interest and pleasure and who achieve a stable response after treatment with adjunctive aticaprant.
Study identification
- NCT ID
- NCT06635135
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 47 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 64 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 19, 2024 (Actual)
- Primary completion
- Apr 9, 2025 (Actual)
- Completion
- Apr 25, 2025 (Actual)
- Last update posted
- Jun 8, 2026
2024 – 2025
United States locations
- U.S. sites
- 31
- U.S. states
- 16
- U.S. cities
- 29
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Preferred Research Partners | Little Rock | Arkansas | 72211 | — |
| Wake Research PRI Encino | Encino | California | 91316 | — |
| Wr Pri Llc | Newport Beach | California | 92660 | — |
| ATP Clinical Research | Orange | California | 92866 | — |
| Myndful Research | Redlands | California | 92373 | — |
| Artemis Institute for Clinical Research | San Diego | California | 92103 | — |
| UHC Research | Doral | Florida | 33178 | — |
| Pharmax Research Clinic Inc | Miami | Florida | 33126 | — |
| GTL Medical and Research Group | Miami | Florida | 33173 | — |
| International Research Associates, LLC | Miami | Florida | 33183 | — |
| Harmony Clinical Research Inc | North Miami Beach | Florida | 33162 | — |
| APG Research LLC | Orlando | Florida | 32803 | — |
| Interventional Psychiatry of Tampa Bay | Tampa | Florida | 33629 | — |
| Synexus Clinical Research US Inc | Atlanta | Georgia | 30328 | — |
| Chicago Research Center | Chicago | Illinois | 60634 | — |
| Psychiatric Medicine Associates LLC | Skokie | Illinois | 60076 | — |
| Continental Clinical Solutions | Towson | Maryland | 21204 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| University of Missouri Health Care | Columbia | Missouri | 65212 | — |
| IMA Clinical Research PC | Albuquerque | New Mexico | 87109 | — |
| Integrative Clinical Trials LLC | Brooklyn | New York | 11229 | — |
| Bioscience Research LLC | Mount Kisco | New York | 10549 | — |
| Patient Priority Clinical Sites LLC | Cincinnati | Ohio | 45215 | — |
| Insight Clinical Trials | Independence | Ohio | 44131 | — |
| Laureate Institute for Brain Research | Tulsa | Oklahoma | 74136 | — |
| Keystone Clinical Studies LLC | Plymouth Meeting | Pennsylvania | 19462 | — |
| Coastal Carolina Research Center | North Charleston | South Carolina | 29405 | — |
| InSite Clinical Research LLC | DeSoto | Texas | 75115 | — |
| Earle Research | Friendswood | Texas | 77546 | — |
| Alpine Research Organization | Clinton | Utah | 84015 | — |
| Elligo Integrated Research Sites Integrated Clinical Research LLC Integrated Psych | St. George | Utah | 84770 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 64 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06635135, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jun 8, 2026 · Synced Oct 29, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06635135 live on ClinicalTrials.gov.