A Phase 1, Randomized, Double-blind, Placebo-controlled Study Evaluating AMG 691 in Healthy Participants and Participants With Mild-to-Moderate Asthma

ClinicalTrials.gov ID: NCT06637371

Public ClinicalTrials.gov record NCT06637371. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Apr 22, 2026, 9:48 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 1, Randomized, Double-blind, Placebo-controlled, Integrated Single Ascending Dose, Multiple Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AMG 691 in Healthy Participants and Participants With Mild-to-Moderate Asthma

Study identification

NCT ID: NCT06637371
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 1
Lead sponsor: Amgen; Industry
Enrollment: 124 participants

Conditions and interventions

Conditions

Asthma

Interventions

AMG 691 Drug
Placebo Drug

Drug

Eligibility (public fields only)

Age range: 18 Years to 65 Years
Sex: All
Healthy volunteers: Accepts healthy volunteers

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Oct 15, 2024
Primary completion: Jun 6, 2027
Completion: Jun 6, 2027
Last update posted: Apr 8, 2026

2024 – 2027

United States locations

U.S. sites: 15
U.S. states: 10
U.S. cities: 15

Facility	City	State	ZIP	Site status
Orange County Research Center	Lake Forest	California	92630	Recruiting
Translational Clinical Research LLC	Aventura	Florida	33180	Recruiting
Destiny Research Center	Palmetto Bay	Florida	33157	Recruiting
ClinCept, LLC	Columbus	Georgia	31904	Completed
Chesapeake Clinical Research Inc	White Marsh	Maryland	21162	Recruiting
Brigham and Womens Hospital	Boston	Massachusetts	02115	Recruiting
Mayflower Clinical	South Dartmouth	Massachusetts	02747	Recruiting
Mayo Clinic	Rochester	Minnesota	55905	Recruiting
Prism Research LLC dba Nucleus Network	Saint Paul	Minnesota	55114	Recruiting
University of North Carolina Clinical and Translational Research Center	Chapel Hill	North Carolina	27599	Recruiting
Monroe Biomedical Research	Monroe	North Carolina	28112	Recruiting
North Carolina Clinical Research	Raleigh	North Carolina	27607	Recruiting
Allergy Asthma and Clinical Research Center	Oklahoma City	Oklahoma	73120	Recruiting
Monroe Biomedical Research	North Charleston	South Carolina	29406	Recruiting
Endeavor Clinical Trials	San Antonio	Texas	78240	Terminated

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 6 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT06637371, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Apr 8, 2026 · Synced Apr 22, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT06637371 live on ClinicalTrials.gov.

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