A Clinical Trial to Learn About the Effects of VHB937 in People With Amyotrophic Lateral Sclerosis (ALS)
Public ClinicalTrials.gov record NCT06643481. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2, Randomized, Double-blind, Placebo-controlled Parallel Group Study of VHB937 in Amyotrophic Lateral Sclerosis (ALS) Over 40 Weeks Followed by an Open Label Extension (ASTRALS)
Study identification
- NCT ID
- NCT06643481
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- Novartis Pharmaceuticals
- Industry
- Enrollment
- 251 participants
Conditions and interventions
Conditions
Interventions
- Placebo Other
- VHB937 Biological
Other · Biological
Eligibility (public fields only)
- Age range
- 18 Years to 100 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 16, 2024
- Primary completion
- Sep 20, 2026
- Completion
- Jul 6, 2028
- Last update posted
- Apr 6, 2026
2024 – 2028
United States locations
- U.S. sites
- 24
- U.S. states
- 15
- U.S. cities
- 24
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of California San Diego | La Jolla | California | 92037 | — |
| Loma Linda University Health | Loma Linda | California | 92354 | — |
| Keck Medical Center USC | Los Angeles | California | 90033 | — |
| UC San Francisco Medical Center | San Francisco | California | 94143 | — |
| University of Miami | Miami | Florida | 33136 | — |
| Orlando Health Clinical Trials | Orlando | Florida | 32806 | — |
| Emory University School of Medicine | Atlanta | Georgia | 30322 | — |
| University Of Kansas Medical Center | Kansas City | Kansas | 66160 | — |
| Johns Hopkins University School of Medicine | Baltimore | Maryland | 21287 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| Neurology Associates P C | Lincoln | Nebraska | 68506-2960 | — |
| University of Nebraska Medical Center | Omaha | Nebraska | 68198 | — |
| Lange Neurology PC | New York | New York | 10065 | — |
| University of Rochester Medical Center | Rochester | New York | 14642 | — |
| Atrium Health | Charlotte | North Carolina | 28207 | — |
| Duke University Health System | Durham | North Carolina | 27710 | — |
| Univ of Cincinnati Medical Center | Cincinnati | Ohio | 45219 | — |
| The Ohio State University | Columbus | Ohio | 43210 | — |
| Providence ALS Center | Portland | Oregon | 97213 | — |
| Temple University | Philadelphia | Pennsylvania | 19140 | — |
| AMR Knoxville | Knoxville | Tennessee | 37920 | — |
| Austin Neuromuscular Center | Austin | Texas | 78759 | — |
| Nerve and Muscle Center of Texas | Houston | Texas | 77030 | — |
| University of Washington Medical Center | Seattle | Washington | 98195 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 62 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06643481, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 6, 2026 · Synced May 8, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06643481 live on ClinicalTrials.gov.