A Study of a Potential Disease Modifying Treatment in Individuals at Risk for or With a Type of Early Onset AD Caused by a Genetic Mutation

ClinicalTrials.gov ID: NCT06647498

Public ClinicalTrials.gov record NCT06647498. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 10, 2026, 10:31 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase II/III Multicenter Randomized, Double-Blind, Placebo-Controlled, Two-Stage Adaptive Design, Platform Trial of Investigational Treatments for Primary Prevention of Disease Progression in Dominantly Inherited Alzheimer's Disease

Study identification

NCT ID: NCT06647498
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 2, Phase 3
Lead sponsor: Washington University School of Medicine; Other
Enrollment: 280 participants

Conditions and interventions

Conditions

Interventions

Matching Placebo (Remternetug) Drug
Remternetug Drug

Drug

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Accepts healthy volunteers

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Nov 21, 2024
Primary completion: Feb 28, 2034
Completion: Jul 31, 2034
Last update posted: Feb 12, 2026

2024 – 2034

United States locations

U.S. sites: 12
U.S. states: 12
U.S. cities: 12

Facility	City	State	ZIP	Site status
University of Alabama in Birmingham	Birmingham	Alabama	35294	Recruiting
University of California San Diego Medical Center	La Jolla	California	92037	Recruiting
Yale University School of Medicine	New Haven	Connecticut	06510	Recruiting
Emory University	Atlanta	Georgia	30329	Recruiting
Advocate Lutheran General Hospital	Park Ridge	Illinois	60068	Recruiting
Indiana University School of Medicine	Indianapolis	Indiana	46202	Recruiting
Washington University in St. Louis	St Louis	Missouri	63110	Recruiting
New York University Medical Center	New York	New York	10016	Recruiting
University of Pittsburgh	Pittsburgh	Pennsylvania	15213	Recruiting
Butler Hospital	Providence	Rhode Island	02096	Recruiting
Kerwin Research and Memory Center	Dallas	Texas	75231	Recruiting
University of Washington	Seattle	Washington	98195	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 23 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT06647498, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Feb 12, 2026 · Synced May 10, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT06647498 live on ClinicalTrials.gov.

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