A Master Protocol for Orforglipron in Participants With Obstructive Sleep Apnea and Obesity or Overweight
Public ClinicalTrials.gov record NCT06649045. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Master Protocol to Investigate the Efficacy and Safety of Orforglipron Once Daily in Participants Who Have Obstructive Sleep Apnea and Obesity or Overweight: A Randomized, Double-Blind, Placebo-Controlled Trial
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Study GZRA is a master protocol that will support 2 independent studies, GZ01 and GZ02. Participants will be assigned to the appropriate study prior to randomization. The purpose of the studies is to evaluate the efficacy and safety of orforglipron in participants who have moderate-to-severe OSA and obesity or overweight. Study GZ01 will include participants who are unable or are unwilling to use PAP therapy. Study GZ02 will include participants who are on PAP therapy for at least 3 months at time of screening and plan to continue PAP therapy during the study.
Study identification
- NCT ID
- NCT06649045
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 712 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 22, 2024 (Actual)
- Primary completion
- Jul 21, 2026 (Actual)
- Completion
- Jul 30, 2026 (Actual)
- Last update posted
- Sep 14, 2026
2024 – 2026
United States locations
- U.S. sites
- 15
- U.S. states
- 11
- U.S. cities
- 15
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Ark Clinical Research | Long Beach | California | 90815 | — |
| Peninsula Research Associates | Rolling Hills Estates | California | 90274 | — |
| Artemis Institute for Clinical Research | San Diego | California | 92103 | — |
| Care Access - Aurora | Aurora | Colorado | 80012 | — |
| EBGS Clinical Research Center | Snellville | Georgia | 30078 | — |
| Elite Clinical Trials | Blackfoot | Idaho | 83221 | — |
| Care Access - Shreveport | Shreveport | Louisiana | 71105 | — |
| The Sleep Spot - Maimonides | Albuquerque | New Mexico | 87107 | — |
| Accellacare - Wilmington | Wilmington | North Carolina | 28401 | — |
| CTI Clinical Research Center | Cincinnati | Ohio | 45212 | — |
| Preferred Primary Care Physicians, Preferred Clinical Research (Ofc 18) | Pittsburgh | Pennsylvania | 15236 | — |
| Preferred Primary Care Physicians | Uniontown | Pennsylvania | 15401 | — |
| FutureSearch Trials of Neurology | Austin | Texas | 78731 | — |
| Prime Revival Research Institute, LLC | Flower Mound | Texas | 75028 | — |
| Northwest Clinical Research Center | Bellevue | Washington | 98007 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 51 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06649045, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 14, 2026 · Synced Oct 23, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06649045 live on ClinicalTrials.gov.