A Study of Ziftomenib in Combination With Imatinib in Patients With Advanced Gastrointestinal Stromal Tumors (GIST)
Public ClinicalTrials.gov record NCT06655246. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 1a/1b Study of the Safety, Pharmacokinetics, and Antitumor Activity of the Oral Menin Inhibitor Ziftomenib in Combination With Imatinib in Patients With Advanced Gastrointestinal Stromal Tumors (GIST) After Imatinib Failure
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
In this clinical trial, the safety, tolerability, and preliminary antitumor activity of ziftomenib in combination with imatinib will be evaluated in adults with gastrointestinal stromal tumors (GIST) who have been treated previously with imatinib.
Study identification
- NCT ID
- NCT06655246
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 1
- Enrollment
- 157 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 26, 2025
- Primary completion
- Nov 30, 2027
- Completion
- Nov 30, 2028
- Last update posted
- Feb 4, 2026
2025 – 2028
United States locations
- U.S. sites
- 32
- U.S. states
- 21
- U.S. cities
- 29
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35233 | Recruiting |
| Mayo Clinic Cancer Center | Phoenix | Arizona | 85054 | Recruiting |
| University of California, San Diego | La Jolla | California | 92093 | Recruiting |
| University of Southern California | Los Angeles | California | 90033 | Recruiting |
| University Of California, Irvine | Orange | California | 92868 | Recruiting |
| Stanford Cancer Institute | Palo Alto | California | 94304 | Recruiting |
| UCLA Santa Monica Medical Center | Santa Monica | California | 90404 | Recruiting |
| University of Colorado Cancer Center | Aurora | Colorado | 80045 | Recruiting |
| Sarah Cannon Research Institute | Denver | Colorado | 80220 | Recruiting |
| Yale University School of Medicine | New Haven | Connecticut | 06511 | Recruiting |
| Mayo Clinic Cancer Center | Jacksonville | Florida | 32224 | Recruiting |
| University of Miami | Miami | Florida | 33136 | Recruiting |
| Northwestern University | Chicago | Illinois | 60611 | Recruiting |
| University of Iowa | Iowa City | Iowa | 52242 | Recruiting |
| Johns Hopkins University | Baltimore | Maryland | 21287 | Recruiting |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | Recruiting |
| Harvard University | Boston | Massachusetts | 02215 | Recruiting |
| University of Michigan | Ann Arbor | Michigan | 48109 | Recruiting |
| Mayo Clinic Cancer Center | Rochester | Minnesota | 55905 | Recruiting |
| Memorial Sloan-Kettering Cancer Center | New York | New York | 10065 | Recruiting |
| Duke University Medical Center | Durham | North Carolina | 27710 | Recruiting |
| Ohio State University | Columbus | Ohio | 43210 | Recruiting |
| Oregon Health & Science University | Portland | Oregon | 97239 | Recruiting |
| Thomas Jefferson University | Philadelphia | Pennsylvania | 19107 | Recruiting |
| Temple University Health System | Philadelphia | Pennsylvania | 19111 | Recruiting |
| Sarah Cannon Research Institute | Nashville | Tennessee | 37203 | Recruiting |
| Vanderbilt University Medical Center | Nashville | Tennessee | 37232 | Recruiting |
| Sarah Cannon Research Institute | Dallas | Texas | 75230 | Recruiting |
| University of Texas | Houston | Texas | 77030 | Recruiting |
| University of Texas Health Science Center | San Antonio | Texas | 78229 | Recruiting |
| University of Utah | Salt Lake City | Utah | 84112 | Recruiting |
| Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06655246, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Feb 4, 2026 · Synced Sep 5, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06655246 live on ClinicalTrials.gov.