Study to Evaluate Efficacy and Safety of ONL1204 in Patients With GA Associated With AMD
Public ClinicalTrials.gov record NCT06659445. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2 Multicenter, Randomized, Double-masked, Sham-controlled, Reference-arm Study to Evaluate Efficacy and Safety of ONL1204 in Patients With Geographic Atrophy (GA) Associated With Age-related Macular Degeneration (AMD)
Study identification
- NCT ID
- NCT06659445
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- ONL Therapeutics
- Industry
- Enrollment
- 324 participants
Conditions and interventions
Interventions
- Avacincaptad Pegol intravitreal solution Drug
- ONL1204 Opthalmic solution Drug
- Sham Other
Drug · Other
Eligibility (public fields only)
- Age range
- 55 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 27, 2025
- Primary completion
- Oct 31, 2028
- Completion
- Oct 31, 2028
- Last update posted
- Dec 4, 2025
2025 – 2028
United States locations
- U.S. sites
- 27
- U.S. states
- 17
- U.S. cities
- 26
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Associated Retina Consultants | Gilbert | Arizona | 85297 | Recruiting |
| Associated Retina Consultants | Phoenix | Arizona | 85020 | Recruiting |
| Doheny Image Reading Center | Pasadena | California | 91103 | Recruiting |
| Bay Area Retina Associates | Walnut Creek | California | 94598 | Recruiting |
| Retina Consultants of Southern Colorado | Colorado Springs | Colorado | 80909-1183 | Recruiting |
| Retina Group of New England | Waterford | Connecticut | 06385 | Recruiting |
| Florida Retina Institute | Orlando | Florida | 32806 | Recruiting |
| Retina Associates, Ltd. | Elmhurst | Illinois | 60126 | Recruiting |
| Retina Partners Midwest, P.C. | Carmel | Indiana | 46032 | Recruiting |
| Retina Research Institute at New England Retina Consultants | Springfield | Massachusetts | 01107 | Recruiting |
| Associated Retinal Consultants, P.C. | Royal Oak | Michigan | 48073 | Recruiting |
| The Retina Institute | St Louis | Missouri | 63128 | Recruiting |
| Sierra Eye Associates | Reno | Nevada | 89502 | Recruiting |
| Retina Associates of Western NY | Rochester | New York | 14620 | Recruiting |
| Long Island Vitreoretinal Consultants | Westbury | New York | 11590 | Recruiting |
| North Carolina Retina Associates, S.C. | Wake Forest | North Carolina | 27587 | Recruiting |
| Erie Retina Research, LLC (Clinic) | Erie | Pennsylvania | 16505 | Recruiting |
| Charleston Neuroscience Institute | Mt. Pleasant | South Carolina | 29464 | Recruiting |
| Palmetto Retina Center | West Columbia | South Carolina | 29169 | Recruiting |
| Retina Consultants of Texas | Beaumont | Texas | 77707 | Recruiting |
| Retina Consultants of Texas | Bellaire | Texas | 77401 | Recruiting |
| Retina Consultants of Texas | Katy | Texas | 77494 | Recruiting |
| Retina Associates of South Texas, PA | San Antonio | Texas | 78240 | Recruiting |
| Retina Consultants of Texas | San Antonio | Texas | 78240 | Recruiting |
| Retina Consultants of Texas | The Woodlands | Texas | 77384 | Recruiting |
| Pacific Northwest Retina | Bellevue | Washington | 98004 | Recruiting |
| Pacific Northwest Retina, PLLC | Silverdale | Washington | 98383 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 1 non-U.S. site.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06659445, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Dec 4, 2025 · Synced May 9, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06659445 live on ClinicalTrials.gov.