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Active, not recruiting Phase 3 Interventional

A 2-year Study of EYP-1901 in Subjects With Wet Age Related Macular Degeneration (wAMD) (LUGANO) Primary Efficacy Will be Determined at Week 56

ClinicalTrials.gov ID: NCT06668064

Public ClinicalTrials.gov record NCT06668064. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

ClinicalTrials.gov public records Last synced Oct 19, 2026, 7:02 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A 2-year Phase 3, Multicenter, Prospective, Randomized, Double-Masked, Parallel-Group Study of EYP-1901, a Tyrosine Kinase Inhibitor (TKI), Compared to Aflibercept in Subjects With Wet AMD

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

This is a phase 3 randomized, double -masked study comparing the efficacy of EYP-1901 against Aflibercept.

Study identification

NCT ID
NCT06668064
Recruitment status
Active, not recruiting
Study type
Interventional
Phase
Phase 3
Lead sponsor
EyePoint Pharmaceuticals, Inc.
Industry
Enrollment
400 participants

Conditions and interventions

Eligibility (public fields only)

Age range
50 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Oct 22, 2024 (Actual)
Primary completion
Jul 13, 2026 (Actual)
Completion
Aug 2027 (Estimated)
Last update posted
Sep 3, 2026

2024 – 2027

United States locations

U.S. sites
76
U.S. states
31
U.S. cities
73
Facility City State ZIP Site status
Retinal Research Institute, LLC Phoenix Arizona 85053 —
Retina Partners of Northwest Arkansas Springdale Arkansas 72764 —
California Retina Consultants Bakersfield California 93309 —
Retina Vitreous Associates Medical Group Beverly Hills California 90211 —
Macula and Retina Institute Glendale California 91203 —
Retina Consultants San Diego Poway California 92064 —
Retina Consultants of Southern California Redlands California 92374 —
Retinal Consultants Medical Group Sacramento California 95841 —
Bay Area Retina Associates Walnut Creek California 94598 —
American Institute of Research Whittier California 95008 —
RSC Research, PLLC Denver Colorado 80210 —
Eye Center of Northern Colorado, PC Fort Collins Colorado 80528 —
Advanced Vision Institute Longmont Colorado 80503 —
Connecticut Eye Consultants, P.C. Danbury Connecticut 06810 —
SightSera Clinical Research LLC Greenwich Connecticut 06830 —
Retina Group of New England, PC Waterford Connecticut 06385 —
Advanced Research, LLC Deerfield Beach Florida 33064 —
Florida Retina Consultants Lakeland Florida 33805 —
Florida Retina Institute Orlando Florida 32806 —
Retina Specialty Institute Pensacola Florida 32503 —
Eye Associates of Pinellas Pinellas Park Florida 33782 —
MedEye Associates South Miami Florida 33143 —
Retina Specialists of Tampa Tampa Florida 33544 —
Retina Vitreous Associates of Florida Tampa Florida 33617 —
Center for Retina & Macular Disease Winter Haven Florida 33880 —
Gerogia Retina Marietta Georgia 30060 —
Retina Consultants of Hawaii ‘Aiea Hawaii 96701 —
Retina Associates Elmhurst Illinois 60126 —
University Retina and Macula Associates Lemont Illinois 60439 —
Midwest Eye Institute Carmel Indiana 46290 —
Retina Associates LLC Lenexa Kansas 66215 —
Maine Eye Center Portland Maine 04101 —
The Retina Care Center Baltimore Maryland 21209 —
Retina Groups of Washington Chevy Chase Maryland 20815 —
Cumberland Valley Retina Consultants Hagerstown Maryland 21740 —
Retina Specialists Towson Maryland 21204 —
Ophthalmic Consultants of Boston OCB - Boston Boston Massachusetts 02114 —
New England Retina Consultants Springfield Massachusetts 01107 —
Retina Associates of Michigan Grand Blanc Michigan 48439 —
Foundation for Vision Research Grand Rapids Michigan 49546 —
Deep Blue Retina Clinical Research PLLC Southaven Mississippi 38671 —
The Retina Institute St Louis Missouri 63128 —
Sierra Eye Associates Reno Nevada 89502 —
NJ Retina Teaneck New Jersey 07666 —
NJ Retina Toms River New Jersey 08755 —
Vision Research Center at Eye Associates of New Mexico Albuquerque New Mexico 87109 —
Retina Vitreous Surgeons of CNY, PC Liverpool New York 13088 —
Retina Associates of Western NY, PC Rochester New York 14620 —
Retina Consultants PLLC Slingerlands New York 12159 —
Western Carolina Retinal Associates, PA Asheville North Carolina 28803 —
Cape Fear Retinal Associates, PC Wilmington North Carolina 28401 —
Piedmont Retina Specialists, P.A. - Winston-Salem Office Winston-Salem North Carolina 27103 —
Tulsa Retina Consultant Tulsa Oklahoma 74114 —
Verum Research LLC Eugene Oregon 97401 —
Erie Retina Research Erie Pennsylvania 16507 —
Eye Care Specialists - Kingston Location Kingston Pennsylvania 18704 —
Retina Consultants Charleston South Carolina 29414 —
Palmetto Retina Center Florence South Carolina 29169 —
Retina Consultants of Carolina P.A Greenville South Carolina 29605 —
Charles Retina Institute Germantown Tennessee 38138 —
Retina Research Institute of Texas Integrated Clinical Research Abilene Texas 79606 —
Retina and Vitreous of Texas Bellaire Texas 77401 —
Retina Consultants of Texas (Retina Consultants of Houston) - Woodlands Bellaire Texas 77401 —
Texas Retina Associates Dallas Texas 75231 —
Texas Retina Associates Plano Texas 75075 —
San Antonio Eye Center San Antonio Texas 78215 —
Retinal Consultants of Texas San Antonio Texas 78240 —
Retina Consultants of Texas The Woodlands Texas 77384 —
Tyler Retina Consultants Tyler Texas 75703 —
Strategic Clinical Research Group, LLC Willow Park Texas 76087 —
Retina Associates of Utah Salt Lake City Utah 84107 —
Salt Lake Retina West Jordan Utah 84088 —
The Retina Group of Washington Fairfax Virginia 22031 —
Piedmont Eye Center Lynchburg Virginia 24502 —
Retina Associates, P.C. Winchester Virginia 22601 —
University of Wisconsin School of Medicine and Public Health (UWSMPH) Madison Wisconsin 53705 —

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT06668064, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Sep 3, 2026 · Synced Oct 19, 2026

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Open the official record

The complete public registry record, listed eligibility criteria, and available contact information for NCT06668064 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →