ClinicalTrials.gov record
A Study to Evaluate VXA-CoV2-3.3 COVID-19 Vaccine Against Currently Approved/Authorized mRNA COVID-19 Injectable Booster Vaccine in Adults Previously Immunized Against COVID-19 Infection
ClinicalTrials.gov ID: NCT06672055
Public ClinicalTrials.gov record NCT06672055. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2b, Double-Blind, Multi-Center, Randomized, Comparator-Controlled Trial to Determine the Relative Efficacy, Safety, and Immunogenicity of the Investigational Oral SARS-CoV-2 Vaccine Tablet Against Currently Approved/Authorized mRNA COVID-19 Injectable Booster Vaccine in Adults Previously Immunized Against COVID-19 Infection
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The primary objective of the study is to determine the relative efficacy of the investigational oral severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) vaccine tablet VXA-CoV2-3.3 compared to a currently recommended vaccine for the prevention of symptomatic Coronavirus Disease 2019 (COVID-19). In order to represent a more recently circulating SARS-CoV-2 variant, the main study endpoints will now evaluate the VXA-CoV2-3.3 (KP.2 strain) vaccine, and not the VXA-CoV2-3.1 (XBB.1.5 strain) vaccine.
Study identification
- NCT ID
- NCT06672055
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 5,485 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 8, 2024 (Actual)
- Primary completion
- May 2027 (Estimated)
- Completion
- May 2027 (Estimated)
- Last update posted
- Oct 9, 2026
2024 – 2027
United States locations
- U.S. sites
- 145
- U.S. states
- 37
- U.S. cities
- 129
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Pinnacle Research Group | Anniston | Alabama | 36207 | — |
| Core Clinical Trials - Central Alabama Research LLC | Birmingham | Alabama | 35209-8401 | — |
| Coastal Clinical Research | Mobile | Alabama | 36608 | — |
| Avacare - Lenzmeier Family Medicine | Glendale | Arizona | 85308 | — |
| Desert Clinical Research | Mesa | Arizona | 85213 | — |
| Velocity Clinical Research - MedPharmics - Phoenix | Phoenix | Arizona | 85020 | — |
| Foothills Research Center | Phoenix | Arizona | 85044 | — |
| Avacare (CCT) - Fiel Family & Sports Medicine | Tempe | Arizona | 85283 | — |
| Baptist Health Center for Clinical Research - Little Rock | Little Rock | Arkansas | 72205 | — |
| Elligo Health Research (BTC/ClinEdge) - Core Healthcare Group | Cerritos | California | 90703 | — |
| Velocity Clinical Research - Chula Vista (eStudySite - Chula Vista) | Chula Vista | California | 91911 | — |
| Avacare - Benchmark Research - SOCAL-Colton | Colton | California | 92324 | — |
| Altasciences Los Angeles (Formerly WCCT Global) | Cypress | California | 90630 | — |
| Ark Clinical Research - Fountain Valley, CA | Fountain Valley | California | 92708 | — |
| Velocity Clinical Research - San Diego (eStudySite - La Mesa) | La Mesa | California | 91942 | — |
| Ark Clinical Research - Long Beach, CA | Long Beach | California | 90815 | — |
| Velocity Clinical Research (National Research Institute) - Panorama City | Los Angeles | California | 90057 | — |
| Northern California Research | Sacramento | California | 95821 | — |
| Avacare - Benchmark Research - Sacramento | Sacramento | California | 95864 | — |
| Velocity Clinical Research - Gardena | Santa Ana | California | 92704 | — |
| Elite Research Network (ERN) - Legacy Clinical Trials | Colorado Springs | Colorado | 80909 | — |
| Tekton Research - Fort Collins | Fort Collins | Colorado | 80528 | — |
| Avacare - Critical Care, Pulmonary and Sleep Associates | Lakewood | Colorado | 80228 | — |
| Tekton Research - Colorado - Longmont | Longmont | Colorado | 80501 | — |
| Paradigm Clinical Research - Wheat Ridge | Wheat Ridge | Colorado | 80033 | — |
| Stamford Therapeutics Consortium | Stamford | Connecticut | 06905 | — |
| Chase Medical Research | Waterbury | Connecticut | 06708 | — |
| Velocity Clinical Research - Washington DC | Washington D.C. | District of Columbia | 20016 | — |
| AMR - Miami (Clinical Research of South Florida) | Coral Gables | Florida | 33134 | — |
| Universal Axon Clinical Research | Doral | Florida | 33166 | — |
| Velocity Clinical Research - New Smyrna Beach | Edgewater | Florida | 32132 | — |
| Fleming Island Center For Clinical Research | Fleming Island | Florida | 32003 | — |
| AMR - Fort Myers - Clinical Physiology Associates | Fort Myers | Florida | 33912 | — |
| Velocity Clinical Research - Hallandale Beach (MD Clinical) | Hallandale | Florida | 33009 | — |
| ENCORE - Nature Coast Clinical Research Inverness | Inverness | Florida | 34452 | — |
| ENCORE - Westside Center for Clinical Research | Jacksonville | Florida | 32205 | — |
| Jacksonville Center for Clinical Research | Jacksonville | Florida | 32216 | — |
| Headlands Research - JEM Research - Lake Worth | Lake Worth | Florida | 33462 | — |
| Accel Research Sites - Lakeland | Lakeland | Florida | 33803 | — |
| Accel Research Sites (ARS) - St. Petersburg - Largo | Largo | Florida | 33777 | — |
| Accel Research Sites - Maitland | Maitland | Florida | 32751 | — |
| K2 Medical Research - Maitland | Maitland | Florida | 32751 | — |
| SRA Trials LLC - Miami Clinical Trials at Suncoast Research Associates | Miami | Florida | 33173 | — |
| Atlas Clinical Research - Suncoast Clinical Research - Pasco County | New Port Richey | Florida | 34652 | — |
| Biscayne Clinical Research | North Miami Beach | Florida | 33169 | — |
| K2 Medical Research - South Orlando | Orlando | Florida | 32806 | — |
| Boca Raton Clinical Research (BRCR) Global - Weston | Plantation | Florida | 33322 | — |
| ENCORE - St. Johns Center for Clinical Research | Saint Augustine | Florida | 32086 | — |
| IMA Clinical Research - St. Petersburg | St. Petersburg | Florida | 33704 | — |
| hyperCORE - Centricity Research Columbus | Columbus | Georgia | 31904 | — |
| Javara Research - Privia Medical Group Georgia | Fayetteville | Georgia | 30214 | — |
| Privia Health - SouthCoast Health | Fayetteville | Georgia | 30214 | — |
| Avacare (CCT) - Lifeline Primary Care | Lilburn | Georgia | 30047 | — |
| hyperCORE - Centricity Research (IACT Health) - Rincon | Rincon | Georgia | 31326 | — |
| Velocity Clinical Research - Savannah | Savannah | Georgia | 31406 | — |
| Velocity Clinical Research - Boise (Meridian) | Meridian | Idaho | 83642 | — |
| IMA Clinical Research - Chicago | Chicago | Illinois | 60602 | — |
| Accellacare - Duly Health and Care | Lombard | Illinois | 60148 | — |
| Velocity Clinical Research - Valparaiso (Buynak Clinical Research) | Valparaiso | Indiana | 46383 | — |
| Accellacare - McFarland Clinic | Ames | Iowa | 50010 | — |
| Velocity (Meridian) Clinical Research - Sioux City | Sioux City | Iowa | 51106 | — |
| AMR - El Dorado - Heartland Research Associates | El Dorado | Kansas | 67042 | — |
| Johnson County Clin-Trials | Lenexa | Kansas | 66219 | — |
| AMR - Newton (Heartland Research Associates) | Newton | Kansas | 67114 | — |
| AMR - Wichita West - Heartland Research Associates | Wichita | Kansas | 67205 | — |
| AMR - Wichita East - Heartland Research Associates | Wichita | Kansas | 67207 | — |
| AMR - Lexington (Central Kentucky Research Associates) | Lexington | Kentucky | 40509 | — |
| Velocity (Meridian) Clinical Research - Baton Rouge | Baton Rouge | Louisiana | 70809 | — |
| Avacare - Benchmark Research - New Orleans-North Shore | Covington | Louisiana | 70433 | — |
| Velocity Clinical Research - MedPharmics - Covington | Covington | Louisiana | 70433 | — |
| Boca Raton Clinical Research (BRCR) Global USA - New Orleans | Gretna | Louisiana | 70053 | — |
| Velocity Clinical Research - MedPharmics - Lafayette | Lafayette | Louisiana | 70508 | — |
| Avacare - Benchmark Research - Metairie | Metairie | Louisiana | 70006 | — |
| AMR - New Orleans - Center for Clinical Research | New Orleans | Louisiana | 70119 | — |
| Javara Research - Privia Medical Group Mid-Atlantic - Annapolis | Annapolis | Maryland | 21401 | — |
| Pharmaron | Baltimore | Maryland | 21201 | — |
| Avacare (CCT) - Advanced Primary and Geriatric Care | Rockville | Maryland | 20850 | — |
| Velocity (Meridian) Clinical Research - Rockville | Rockville | Maryland | 20854 | — |
| Javara Research - Mankato Clinic | Mankato | Minnesota | 56001 | — |
| Velocity Clinical Research - MedPharmics - Gulfport | Gulfport | Mississippi | 39503 | — |
| Avacare (CCT) - Clay Platte Family Medicine Clinic | Kansas City | Missouri | 64151 | — |
| Avacare (CCT) - Skyline Medical Center | Elkhorn | Nebraska | 68022 | — |
| Velocity (Meridian) Clinical Research - Grand Island | Grand Island | Nebraska | 68803 | — |
| Be Well Clinical Studies - Nebraska | Lincoln | Nebraska | 68516 | — |
| Velocity (Meridian) Clinical Research - Omaha | Omaha | Nebraska | 68134 | — |
| hyperCORE - ActivMed Practices and Research - Portsmouth | Portsmouth | New Hampshire | 03801 | — |
| DM Clinical Research - Jersey City | Jersey City | New Jersey | 07306 | — |
| Velocity Clinical Research - Alburquerque | Albuquerque | New Mexico | 87107 | — |
| AXCES Research & Health - Santa Fe | Santa Fe | New Mexico | 87505 | — |
| IMA Clinical Research - Albany, Suite 202 | Albany | New York | 12205 | — |
| Velocity Clinical Research - Syracuse | East Syracuse | New York | 13057 | — |
| IMA Clinical Research - Manhattan | New York | New York | 10036 | — |
| Atlas Clinical Research - Rochester Clinical Research | Rochester | New York | 14609 | — |
| Cary Medical Group | Cary | North Carolina | 27518 | — |
| Velocity Clinical Research - Durham | Durham | North Carolina | 27701 | — |
| Accellacare - Hickory | Hickory | North Carolina | 28601 | — |
| Accellacare - Raleigh | Raleigh | North Carolina | 27609 | — |
| Accellacare - Rocky Mount | Rocky Mount | North Carolina | 27804 | — |
| Accellacare - Salisbury | Salisbury | North Carolina | 28144 | — |
| Accellacare - Piedmont Healthcare | Statesville | North Carolina | 28625 | — |
| Accellacare - Tradd Court | Wilmington | North Carolina | 28401 | — |
| Accellacare - Winston-Salem | Winston-Salem | North Carolina | 27103 | — |
| Atrium Health Wake Forest Baptist - Comprehensive Cancer Center | Winston-Salem | North Carolina | 27157 | — |
| Velocity Clinical Research - Cleveland (Rapid Medical Research) | Beachwood | Ohio | 44122 | — |
| CTI Clinical Research Center | Cincinnati | Ohio | 45212 | — |
| Velocity Clinical Research - Cincinnati (New Horizons Clinical Research - Blue Ash) | Cincinnati | Ohio | 45242 | — |
| Tekton Research - Oklahoma - Magnolia Court | Moore | Oklahoma | 73160 | — |
| Tekton Research - Delaware Pointe | Tulsa | Oklahoma | 74137 | — |
| Tekton Research - Oklahoma - Primary Health Partners | Yukon | Oklahoma | 73099 | — |
| Velocity Clinical Research - Grants Pass | Grants Pass | Oregon | 97527 | — |
| Avacare (CCT) - Hatboro Medical Associates | Hatboro | Pennsylvania | 19040 | — |
| Atlas Clinical Research - Suburban Research Associates - Media Office | Media | Pennsylvania | 19063 | — |
| Velocity Clinical Research - Providence (East Greenwich) | East Greenwich | Rhode Island | 02818 | — |
| Velocity Clinical Research - Anderson | Anderson | South Carolina | 29621 | — |
| Velocity Clinical Research - Charleston | Charleston | South Carolina | 29414 | — |
| Velocity Clinical Research - Columbia (VitaLink) | Columbia | South Carolina | 29204 | — |
| Accellacare - Charleston | Mt. Pleasant | South Carolina | 29464 | — |
| Trial Management Associates - Myrtle Beach | Myrtle Beach | South Carolina | 29572 | — |
| hyperCORE International - Coastal Carolina Research Center | North Charleston | South Carolina | 29405 | — |
| Velocity Clinical Research - Union (Vitalink) | Union | South Carolina | 29379 | — |
| Accellacare - PMG Research of Bristol | Bristol | Tennessee | 37620 | — |
| Alliance for Multispecialty Research (AMR) - Corporate | Knoxville | Tennessee | 37909 | — |
| Accellacare of Knoxville | Knoxville | Tennessee | 37912 | — |
| Velocity Clinical Research - Abilene | Abilene | Texas | 79606 | — |
| IMA Clinical Research - Austin | Austin | Texas | 78745 | — |
| Tekton Research - Austin | Austin | Texas | 78745 | — |
| Orion Clinical Research | Austin | Texas | 78759 | — |
| Velocity Clinical Research - Austin | Austin | Texas | 78759 | — |
| Tekton Research - Beaumont | Beaumont | Texas | 77706 | — |
| PanAmerican Clinical Research - Brownsville, Levee Street | Brownsville | Texas | 78520 | — |
| Cedar Health Research - Arlington/Euless | Euless | Texas | 76040 | — |
| EmVenio Research - Fort Worth, TX | Fort Worth | Texas | 76134 | — |
| Avacare - Benchmark Research Fort Worth | Fort Worth | Texas | 76135 | — |
| DM Clinical Research - CyFair Clinical Research Center | Houston | Texas | 77065 | — |
| Tekton Research - Fredericksburg Road | San Antonio | Texas | 78229 | — |
| DM Clinical Research - Tomball - Multiple Specialties | Tomball | Texas | 77375 | — |
| Velocity Clinical Research - Waco (formerly: Impact Research Institute) | Waco | Texas | 76710 | — |
| Avacare (CCT) - Ogden Clinic - Grand View | Roy | Utah | 84067 | — |
| Avacare (CCT) - Olympus Family Medicine | Salt Lake City | Utah | 84117 | — |
| South Ogden Family Medicine | South Ogden | Utah | 84405 | — |
| Health Research of Hampton Roads | Newport News | Virginia | 23606 | — |
| AMR - Norfolk (Clinical Research Associates of Tidewater) | Norfolk | Virginia | 23502 | — |
| Centricity Research (IACT Health) - Suffolk Primary Care | Suffolk | Virginia | 23435 | — |
| Velocity Clinical Research - Medford | Spokane | Washington | 99204 | — |
| Velocity Clinical Research - Spokane | Spokane | Washington | 99204 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06672055, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 9, 2026 · Synced Oct 17, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06672055 live on ClinicalTrials.gov.