A Study of the Efficacy and Safety of Efgartigimod in Patients With Primary Sjögren's Syndrome
Public ClinicalTrials.gov record NCT06684847. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3 Randomized, Double-Blinded, Placebo-Controlled Multicenter Trial With Open-Label Extension to Evaluate the Efficacy, Safety, and Tolerability of Efgartigimod PH20 Subcutaneous Administered by Prefilled Syringe in Adult Patients With Primary Sjögren's Disease
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The main purpose of the proposed study is to evaluate the efficacy of efgartigimod PH20 SC in patients with moderate-to-severe Primary Sjögren's Disease (pSjD). The study consists of a double-blinded placebo-controlled treatment period and an open-label treatment period. The maximum study duration for participants in both study parts is approximately 105 weeks.
Study identification
- NCT ID
- NCT06684847
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 631 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 15, 2025 (Actual)
- Primary completion
- Jul 2027 (Estimated)
- Completion
- Jul 2028 (Estimated)
- Last update posted
- Apr 16, 2026
2025 – 2028
United States locations
- U.S. sites
- 42
- U.S. states
- 16
- U.S. cities
- 39
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| One of a Kind Clinical Research Center LLC | Scottsdale | Arizona | 85258 | — |
| Arizona Arthritis & Rheumatology Research, PLLC | Sun City | Arizona | 85351 | — |
| Arizona Arthritis & Rheumatology Research, PLLC | Tucson | Arizona | 85748 | — |
| Providence Medical Foundation | Fullerton | California | 92835 | — |
| Stanford University School of Medicine | Stanford | California | 94305 | — |
| University of Colorado | Aurora | Colorado | 80045 | — |
| Clinical Research of West Florida, Inc. | Clearwater | Florida | 33765 | — |
| Centre for Rheumatology, Immunology and Arthritis | Fort Lauderdale | Florida | 33309 | — |
| Finlay Medical Research Corp | Greenacres City | Florida | 33647 | — |
| University of Florida College of Medicine Jacksonville | Jacksonville | Florida | 32256 | — |
| Life Clinical Trials | Margate | Florida | 33063 | — |
| Clinical Research of West Florida, Inc. | Tampa | Florida | 33606 | — |
| Conquest Research | Winter Park | Florida | 32789 | — |
| Piedmont Healthcare, Inc. | Atlanta | Georgia | 30318 | — |
| St. Luke's Clinic - Rheumatology | Boise | Idaho | 83702 | — |
| Chicago Clinical Research Institute | Chicago | Illinois | 60607 | — |
| Great Lakes Clinical Trials, LLC Ravenswood dba Flourish Research | Chicago | Illinois | 60640 | — |
| Chicago Arthritis & Regenerative Medicine | Chicago | Illinois | 60657 | — |
| Greater Chicago Specialty Physicians LLC | Orland Park | Illinois | 60467 | — |
| Arizona Arthritis & Rheumatology Research, PLLC | Willowbrook | Illinois | 60527 | — |
| Lake Cumberland Rheumatology | New Albany | Indiana | 47150 | — |
| University of Iowa Hospital and Clinics | Iowa City | Iowa | 52242 | — |
| Accurate Clinical Research Inc. | Lake Charles | Louisiana | 70605 | — |
| The Johns Hopkins Hospital | Baltimore | Maryland | 21224 | — |
| Arthritis and Rheumatism Associates | Rockville | Maryland | 20850 | — |
| Washington University School of Medicine | St Louis | Missouri | 63110 | — |
| Joseph S. and Diane H. Steinberg Ambulatory Care Center | Brooklyn | New York | 11201 | — |
| Samaritan Health Services | Corvallis | Oregon | 97330 | — |
| East Penn Rheumatology Associates, P.C. | Bethlehem | Pennsylvania | 18105 | — |
| Rheumatic Disease Associates, Ltd. | Willow Grove | Pennsylvania | 19090 | — |
| Allen Arthritis | Allen | Texas | 75013 | — |
| Accurate Clinical Management | Baytown | Texas | 77521 | — |
| Novel Research LLC | Bellaire | Texas | 77401 | — |
| Precision Comprehensive Clinical Research Solution | Colleyville | Texas | 76034-5913 | — |
| Southwest Family Medicine Associates | Dallas | Texas | 75235 | — |
| Arizona Arthritis & Rheumatology Research, PLLC | Fort Worth | Texas | 76109 | — |
| Accurate Clinical Research, Inc. | Houston | Texas | 77089 | — |
| North Houston Arthritis Center | Houston | Texas | 77090 | — |
| Arizona Arthritis & Rheumatology Research, PLLC | Irving | Texas | 75039 | — |
| R and H Clinical Research | Katy | Texas | 77450 | — |
| Simcare Medical Research LLC | Sugar Land | Texas | 77478 | — |
| Velocity Clinical Research Waco | Waco | Texas | 76712 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 261 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06684847, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 16, 2026 · Synced Oct 21, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06684847 live on ClinicalTrials.gov.