Phase 3 Study of Xaluritamig vs Cabazitaxel or Second Androgen Receptor-Directed Therapy in Participants With Progressive Metastatic Castration-Resistant Prostate Cancer (XALute)

ClinicalTrials.gov ID: NCT06691984

Public ClinicalTrials.gov record NCT06691984. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 7, 2026, 9:03 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 3, Open-label, Multicenter, Randomized Study of Xaluritamig vs Cabazitaxel or Second Androgen Receptor-Directed Therapy in Subjects With Metastatic Castration-Resistant Prostate Cancer Previously Treated With Chemotherapy

Study identification

NCT ID: NCT06691984
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: Amgen; Industry
Enrollment: 675 participants

Conditions and interventions

Conditions

Metastatic Castration-resistant Prostate Cancer

Interventions

Abiraterone Drug
Cabazitaxel Drug
Enzalutamide Drug
Xaluritamig Drug

Drug

Eligibility (public fields only)

Age range: 18 Years and older
Sex: Male
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Dec 8, 2024
Primary completion: Jan 1, 2029
Completion: Jul 29, 2029
Last update posted: Mar 5, 2026

2024 – 2029

United States locations

U.S. sites: 42
U.S. states: 23
U.S. cities: 35

Facility	City	State	ZIP	Site status
University of Alabama at Birmingham	Birmingham	Alabama	35233	Recruiting
City of Hope National Medical Center	Duarte	California	91010	Recruiting
Providence Saint Jude Medical Center	Fullerton	California	92835	Recruiting
Cedars Sinai Medical Center	Los Angeles	California	90048	Recruiting
University of California Irvine	Orange	California	92868	Recruiting
University of California San Francisco	San Francisco	California	94158	Recruiting
University of Florida, College of Medicine	Gainesville	Florida	32610	Recruiting
Sylvester Comprehensive Cancer Center-Fox Building	Miami	Florida	33136	Recruiting
AdventHealth Orlando	Orlando	Florida	32804	Recruiting
University of Chicago	Chicago	Illinois	60637	Recruiting
Indiana University	Indianapolis	Indiana	46202	Recruiting
University of Louisville Health - James Graham Brown Cancer Center	Louisville	Kentucky	40202	Recruiting
Norton Cancer Institute	Louisville	Kentucky	40207	Recruiting
Massachusetts General Hospital	Boston	Massachusetts	02114	Recruiting
Beth Israel Deaconess Medical Center	Boston	Massachusetts	02215	Recruiting
Dana-Farber Cancer Institute	Boston	Massachusetts	02215	Recruiting
Henry Ford Hospital, Henry Ford Health Systems	Detroit	Michigan	48202	Recruiting
University of Minnesota	Minneapolis	Minnesota	55455	Recruiting
Washington University	St Louis	Missouri	63110	Recruiting
Yale New Haven Hospital	New York	New York	10032	Recruiting
Memorial Sloan Kettering Cancer Center	New York	New York	10065	Recruiting
Montefiore Medical Center	The Bronx	New York	10467	Recruiting
Levine Cancer Institute	Charlotte	North Carolina	28204	Recruiting
Duke University	Durham	North Carolina	27710	Recruiting
Sanford Roger Maris Cancer Center	Fargo	North Dakota	58122	Recruiting
Cleveland Clinic Foundation	Cleveland	Ohio	44195	Recruiting
The Ohio State University	Columbus	Ohio	43210	Recruiting
Oregon Health and Science University	Portland	Oregon	97239	Recruiting
Thomas Jefferson University Hospital	Philadelphia	Pennsylvania	19107	Recruiting
Fox Chase Cancer Center	Philadelphia	Pennsylvania	19111	Recruiting
University of Pittsburgh Medical Center	Pittsburgh	Pennsylvania	15232	Recruiting
Sanford Oncology Clinic and Pharmacy	Sioux Falls	South Dakota	57104	Recruiting
Sarah Cannon Research Institute	Nashville	Tennessee	37203	Recruiting
Tennessee Oncology PLLC	Nashville	Tennessee	37203	Recruiting
University of Texas Southwestern Medical Center	Dallas	Texas	75390	Recruiting
University of Texas MD Anderson Cancer Center	Houston	Texas	77030	Recruiting
Intermountain Medical Center	Murray	Utah	84107	Recruiting
Virginia Oncology Associates	Norfolk	Virginia	23502	Recruiting
Fred Hutchinson Cancer Center	Seattle	Washington	98019-1024	Recruiting
Swedish Medical Center	Seattle	Washington	98104	Recruiting
University of Wisconsin Carbone Cancer Center	Madison	Wisconsin	53705	Recruiting
Medical College of Wisconsin	Milwaukee	Wisconsin	53226	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 122 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT06691984, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Mar 5, 2026 · Synced May 7, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT06691984 live on ClinicalTrials.gov.

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