Independent directory Public ClinicalTrials.gov records United States
Clinical Trials Finder
Objective public record navigation
ClinicalTrials.gov record
Recruiting Phase 2 Interventional

Safety, Efficacy, and Pharmacokinetics of CSL889 in Adults and Adolescents With Sickle Cell Disease During Vaso-Occlusive Crisis

ClinicalTrials.gov ID: NCT06699849

Public ClinicalTrials.gov record NCT06699849. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

View official ClinicalTrials.gov record → Back to search
ClinicalTrials.gov public records Last synced Sep 11, 2026, 6:24 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 2, Multicenter, Randomized, Multiple-Dose, Double-Blind, Placebo-Controlled Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of CSL889 in Adults and Adolescents With Sickle Cell Disease During Vaso-Occlusive Crisis

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

This is a phase 2, randomized, multiple-dose, placebo-controlled study designed to evaluate the safety, efficacy, and pharmacokinetics (PK) of CSL889 (human hemopexin) when given intravenously (IV) to adults and adolescents with sickle cell disease (SCD) experiencing vaso-occlusive crises (VOC). The main objectives of the study are to evaluate the safety and tolerability of CSL889 in study participants, and to assess how CSL889 affects the time it takes for VOC to resolve in participants with SCD.

Study identification

NCT ID
NCT06699849
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 2
Lead sponsor
CSL Behring
Industry
Enrollment
70 participants

Conditions and interventions

Interventions

Biological · Drug

Eligibility (public fields only)

Age range
12 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Aug 6, 2025
Primary completion
Oct 21, 2027
Completion
Oct 21, 2027
Last update posted
Aug 13, 2026

2025 – 2027

United States locations

U.S. sites
19
U.S. states
13
U.S. cities
17
Facility City State ZIP Site status
Univ. of California, San Francisco Health Care Oakland California 94609 Recruiting
University of California Irvine Orange California 92868 Not yet recruiting
Golisano Children's Hospital Fort Myers Florida 33908 Recruiting
The Foundation for Sickle Cell Disease Hollywood Florida 33023-6703 Recruiting
Arthur M. Blank Hospital-Children's Healthcare of Atlanta Atlanta Georgia 30329 Recruiting
University of Illinois at Chicago Chicago Illinois 60612 Recruiting
University of Louisville Hospital Louisville Kentucky 40202 Recruiting
University of Maryland Baltimore Maryland 21201 Recruiting
Detroit Medical Center Detroit Michigan 48201 Recruiting
Henry Ford Health System Detroit Michigan 48202 Recruiting
St. Louis Children's Hospital St Louis Missouri 63110 Recruiting
Mount Sinai Medical Center New York New York 10029 Recruiting
Jacobi Medical Center The Bronx New York 10461 Recruiting
East Carolina University Greenville North Carolina 27834 Recruiting
University of Cincinnati Cincinnati Ohio 45267 Recruiting
The Ohio State University Columbus Ohio 43085 Recruiting
University of Pittsburgh Pittsburgh Pennsylvania 15224 Recruiting
Hillman Cancer Center Pittsburgh Pennsylvania 15232 Recruiting
Virginia Commonwealth University Richmond Virginia 23298 Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 7 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT06699849, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Aug 13, 2026 · Synced Sep 11, 2026

Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT06699849 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →