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Recruiting Phase 3 Interventional

Safety and Efficacy of BNT327, an Investigational Therapy in Combination With Chemotherapy for Patients With Untreated Small-cell Lung Cancer

ClinicalTrials.gov ID: NCT06712355

Public ClinicalTrials.gov record NCT06712355. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Sep 3, 2026, 9:20 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase III, Multisite, Double-blinded Randomized Trial of BNT327 in Combination With Chemotherapy (Etoposide/Carboplatin) Compared to Atezolizumab in Combination With Chemotherapy (Etoposide/Carboplatin) in Participants With First-line Extensive-stage Small-cell Lung Cancer

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

This is a Phase III, multisite, randomized, double-blinded study to investigate pumitamig (BNT327) combined with chemotherapy (etoposide/carboplatin) compared to atezolizumab combined with chemotherapy (etoposide/carboplatin) for the treatment of participants with previously untreated extensive-stage small-cell lung cancer (ES-SCLC).

Study identification

NCT ID
NCT06712355
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 3
Lead sponsor
BioNTech SE
Industry
Enrollment
621 participants

Conditions and interventions

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Feb 2, 2025
Primary completion
Nov 30, 2028
Completion
Feb 28, 2029
Last update posted
Aug 31, 2026

2025 – 2029

United States locations

U.S. sites
36
U.S. states
19
U.S. cities
32
Facility City State ZIP Site status
ACRC Arizona Clinical Research Center Tucson Arizona 85715 Recruiting
Clermont Oncology Center Clermont Florida 34711 Terminated
Cancer Care Centers of Brevard, Inc Palm Bay Florida 32901 Recruiting
Northside Hospital Atlanta Atlanta Georgia 30342 Recruiting
Illinois Cancer Specialists Niles Illinois 60714 Recruiting
Fort Wayne Medical Oncology and Hematology, Inc Fort Wayne Indiana 46804 Recruiting
McFarland Clinic Ames Iowa 50010 Recruiting
Helen G. Nassif Community Cancer Center Cedar Rapids Iowa 52403 Recruiting
Baptist Health Hardin Cancer Center Elizabethtown Kentucky 42701 Recruiting
LSU Health Baton Rouge - North Clinic Baton Rouge Louisiana 70805 Recruiting
Our Lady of the Lake Hospital, Inc. Baton Rouge Louisiana 70808 Recruiting
Frederick Health Hospital- James M Stockman Cancer Institute Frederick Maryland 21704 Recruiting
Beth Israel Lahey Health - Lahey Hospital & Medical Center (LHMC), Lahey Clinic Medical Center Burlington Massachusetts 01805 Recruiting
Baptist Cancer Center Southaven Mississippi 38671 Recruiting
Washington University School of Medicine St Louis Missouri 63110 Recruiting
Nebraska Hematology-Oncology (NHO) Lincoln Nebraska 68506 Recruiting
Cornell University - NewYork-Presbyterian/Weill Cornell Medical Center New York New York 10065 Recruiting
White Plains Hospital White Plains New York 10601 Recruiting
Cleveland Clinic - Akron General Hematology & Oncology Akron Ohio 44302 Recruiting
Cleveland Clinic Mercy Hospital Cancer Center Canton Ohio 44708 Recruiting
The Christ Hospital Cancer Center Cincinnati Ohio 45219 Recruiting
University Hospitals Cleveland Medical Center Cleveland Ohio 44106 Recruiting
The Cleveland Clinic Cancer Center at Fairview Hospital, Moll Pavilion Cleveland Ohio 44111 Recruiting
Cleveland Clinic Foundation Cleveland Ohio 44195-0001 Recruiting
Kettering Medical Center Kettering Ohio 45429 Recruiting
Cleveland Clinic - Hillcrest Hospital Mayfield Heights Ohio 44124 Recruiting
St. Luke's Physician Group - St. Luke's Cancer Care Associates Fountain Hill Pennsylvania 18015-1153 Recruiting
West Cancer Center & Research Institute Germantown Tennessee 38138 Recruiting
University of Tennessee Medical Center Knoxville Tennessee 37920 Recruiting
The University of Texas MD Anderson Cancer Center Houston Texas 77030 Recruiting
Millennium Research and Clinical Development, LLC Houston Texas 77090 Terminated
Texas Oncology Cancer Center Sugar Land Texas 77479 Recruiting
Virginia Cancer Specialists Fairfax Virginia 22031 Recruiting
Hematology Oncology Associates of Fredericksburg, Inc. Fredericksburg Virginia 22408 Recruiting
Virginia Commonwealth University School of Medicine Richmond Virginia 23298 Recruiting
Shenandoah Oncology Winchester Virginia 22601 Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 189 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT06712355, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Aug 31, 2026 · Synced Sep 3, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT06712355 live on ClinicalTrials.gov.

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