Safety and Efficacy of BNT327, an Investigational Therapy in Combination With Chemotherapy for Patients With Untreated Small-cell Lung Cancer
Public ClinicalTrials.gov record NCT06712355. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase III, Multisite, Double-blinded Randomized Trial of BNT327 in Combination With Chemotherapy (Etoposide/Carboplatin) Compared to Atezolizumab in Combination With Chemotherapy (Etoposide/Carboplatin) in Participants With First-line Extensive-stage Small-cell Lung Cancer
Study identification
- NCT ID
- NCT06712355
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- BioNTech SE
- Industry
- Enrollment
- 621 participants
Conditions and interventions
Conditions
Interventions
- Atezolizumab Drug
- Carboplatin (or cisplatin if carboplatin is not tolerated) Drug
- Etoposide Drug
- Pumitamig Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 2, 2025
- Primary completion
- Nov 30, 2028
- Completion
- Feb 28, 2029
- Last update posted
- Feb 12, 2026
2025 – 2029
United States locations
- U.S. sites
- 30
- U.S. states
- 16
- U.S. cities
- 27
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Clermont Oncology Center | Clermont | Florida | 34711 | Terminated |
| Cancer Care Centers of Brevard, Inc | Palm Bay | Florida | 32901 | Recruiting |
| Illinois Cancer Specialists | Niles | Illinois | 60714 | Recruiting |
| Fort Wayne Medical Oncology and Hematology, Inc | Fort Wayne | Indiana | 46804 | Recruiting |
| McFarland Clinic | Ames | Iowa | 50010 | Recruiting |
| Helen G. Nassif Community Cancer Center | Cedar Rapids | Iowa | 52403 | Recruiting |
| Baptist Health Hardin Cancer Center | Elizabethtown | Kentucky | 42701 | Recruiting |
| Frederick Health Hospital- James M Stockman Cancer Institute | Frederick | Maryland | 21704 | Recruiting |
| Beth Israel Lahey Health - Lahey Hospital & Medical Center (LHMC), Lahey Clinic Medical Center | Burlington | Massachusetts | 01805 | Recruiting |
| Baptist Cancer Center | Southaven | Mississippi | 38671 | Recruiting |
| Washington University School of Medicine | St Louis | Missouri | 63110 | Recruiting |
| Nebraska Hematology-Oncology (NHO) | Lincoln | Nebraska | 68506 | Recruiting |
| White Plains Hospital | White Plains | New York | 10601 | Recruiting |
| Cleveland Clinic - Akron General Hematology & Oncology | Akron | Ohio | 44302 | Recruiting |
| Cleveland Clinic Mercy Hospital Cancer Center | Canton | Ohio | 44708 | Recruiting |
| The Christ Hospital Cancer Center | Cincinnati | Ohio | 45219 | Recruiting |
| University Hospitals Cleveland Medical Center | Cleveland | Ohio | 44106 | Recruiting |
| The Cleveland Clinic Cancer Center at Fairview Hospital, Moll Pavilion | Cleveland | Ohio | 44111 | Recruiting |
| Cleveland Clinic Foundation | Cleveland | Ohio | 44195-0001 | Recruiting |
| Kettering Medical Center | Kettering | Ohio | 45429 | Recruiting |
| Cleveland Clinic - Hillcrest Hospital | Mayfield Heights | Ohio | 44124 | Recruiting |
| St. Luke's Physician Group - St. Luke's Cancer Care Associates | Fountain Hill | Pennsylvania | 18015-1153 | Recruiting |
| University of Tennessee Medical Center | Knoxville | Tennessee | 37920 | Recruiting |
| The University of Texas MD Anderson Cancer Center | Houston | Texas | 77030 | Recruiting |
| Millennium Research and Clinical Development, LLC | Houston | Texas | 77090 | Terminated |
| Texas Oncology Cancer Center | Sugar Land | Texas | 77479 | Recruiting |
| Virginia Cancer Specialists | Fairfax | Virginia | 22031 | Recruiting |
| Hematology Oncology Associates of Fredericksburg, Inc. | Fredericksburg | Virginia | 22408 | Recruiting |
| Virginia Commonwealth University School of Medicine | Richmond | Virginia | 23298 | Recruiting |
| Shenandoah Oncology | Winchester | Virginia | 22601 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 108 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06712355, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Feb 12, 2026 · Synced May 6, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06712355 live on ClinicalTrials.gov.