Efficacy and Safety of GZR18 Every 2 Weeks Versus Tirzepatide and Placebo in Obese or Overweight Participants
Public ClinicalTrials.gov record NCT06737042. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
EFFICACY AND SAFETY OF GZR18 INJECTED EVERY 2 WEEKS (Q2W) IN PARTICIPANTS WITHOUT TYPE 2 DIABETES, WHO HAVE OBESITY OR ARE OVERWEIGHT: A RANDOMIZED, TIRZEPATIDE- AND PLACEBO-CONTROLLED STUDY
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a Phase 2 study to evaluate the safety and efficacy of 24, 36, and 48 mg GZR18 (Q2W) compared with placebo and 15 mg tirzepatide (QW). The study will evaluate weight management in participants with obesity (BMI ≥30 kg/m2) or who are overweight (BMI ≥27 kg/m2) with weight-related comorbidities (excluding type 2 diabetes mellitus).
Study identification
- NCT ID
- NCT06737042
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 326 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 75 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 24, 2025 (Actual)
- Primary completion
- Feb 27, 2026 (Actual)
- Completion
- Feb 27, 2026 (Actual)
- Last update posted
- Jul 16, 2026
2025 – 2026
United States locations
- U.S. sites
- 20
- U.S. states
- 9
- U.S. cities
- 19
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| KUR Research - Trinity @ Bessemer, AL Site Network | Bessemer | Alabama | 35022 | — |
| KUR Research - Trinity @ Centreville Site Network | Centreville | Alabama | 35042 | — |
| ERG - Woodland Int'l Research Group | Little Rock | Arkansas | 72211 | — |
| ERG - Woodland Research Northwest | Rogers | Arkansas | 72758 | — |
| Ark Clinical Research Ark-Fountain Valley | Fountain Valley | California | 92708 | — |
| Ark Clinical Research Ark-Long Beach | Long Beach | California | 90815 | — |
| Clinedge - Central Valley Research, LLC | Modesto | California | 95350 | — |
| Populace Health, LLC - Catalina Research Institute | Montclair | California | 91763 | — |
| East Coast Institute for Research - ECIR Jacksonville (Southside) | Jacksonville | Florida | 32216 | — |
| East Coast Institute for Research ECIR Jacksonville (Headquarters) University | Jacksonville | Florida | 32216 | — |
| 3Sync Research - PCRS Network | Lake Worth | Florida | 33460 | — |
| Clever Medical Research - PCRS Network | Miami | Florida | 33126 | — |
| KUR Research @ Columbia Site Network | Columbia | Maryland | 21045 | — |
| Populace Health, LLC - Elixia SISU | Springfield | Massachusetts | 01103 | — |
| Populace Health, LLC - Vector Clinical Trials | Las Vegas | Nevada | 89128 | — |
| Populace Health, LLC - CTI Clinical Research Center | Cincinnati | Ohio | 45212 | — |
| ERG - Ohio Clinical Trials | Columbus | Ohio | 43212 | — |
| Elligo Clinical Research Center - Austin | Austin | Texas | 78704 | — |
| Clinvax Katy Research Center | Katy | Texas | 77493 | — |
| Endeavor Clinical Trials | San Antonio | Texas | 78229 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06737042, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 16, 2026 · Synced Sep 30, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06737042 live on ClinicalTrials.gov.