A Study to Investigate the Efficacy and Safety of Sonrotoclax Plus Zanubrutinib Compared With Placebo Plus Zanubrutinib in Adults With Relapsed/Refractory Mantle Cell Lymphoma (CELESTIAL-RRMCL)
Public ClinicalTrials.gov record NCT06742996. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3 Randomized Double-Blind Multicenter Study of Sonrotoclax Plus Zanubrutinib Versus Placebo Plus Zanubrutinib in Patients With Relapsed/Refractory Mantle Cell Lymphoma
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The goal of this study is to compare how well sonrotoclax plus zanubrutinib works versus zanubrutinib plus placebo in treating adults with relapsed/refractory (R/R) mantle cell lymphoma (MCL). This study will also look at the safety of sonrotoclax plus zanubrutinib versus zanubrutinib plus placebo.
Study identification
- NCT ID
- NCT06742996
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 300 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 4, 2025
- Primary completion
- Aug 30, 2028
- Completion
- Mar 29, 2032
- Last update posted
- Aug 18, 2026
2025 – 2032
United States locations
- U.S. sites
- 41
- U.S. states
- 26
- U.S. cities
- 37
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama At Birmingham Hospital | Birmingham | Alabama | 35294-0004 | Recruiting |
| University of Arizona Cancer Center | Tucson | Arizona | 85724-0001 | Recruiting |
| Ucsf Fresno | Fresno | California | 93701 | Recruiting |
| Kaiser Permanente Southern California | Irvine | California | 92618-3734 | Recruiting |
| Yale University Yale Cancer Center | New Haven | Connecticut | 06520-8028 | Recruiting |
| Memorial Cancer Institute, Memorial Healthcare System | Pembroke Pines | Florida | 33026-4119 | Recruiting |
| Cleveland Clinic Florida | Weston | Florida | 33331-3609 | Recruiting |
| Rush University Medical Center | Chicago | Illinois | 60607 | Recruiting |
| University of Chicago Medical Center | Chicago | Illinois | 60637-1443 | Recruiting |
| Fort Wayne Medical Oncology and Hematology | Fort Wayne | Indiana | 46804 | Recruiting |
| Mission Cancer and Blood | Waukee | Iowa | 50263 | Recruiting |
| Our Lady of the Lake Hospital | Baton Rouge | Louisiana | 70808-4365 | Recruiting |
| The University of Maryland Greenebaum Comprehensive Cancer Center | Baltimore | Maryland | 21201 | Recruiting |
| Dana Farber Cancer Institute Longwood Medical Center | Boston | Massachusetts | 02215-5418 | Recruiting |
| University of Michigan | Ann Arbor | Michigan | 48109-1382 | Recruiting |
| The Cancer and Hematology Centers | Grand Rapids | Michigan | 49503-2563 | Recruiting |
| Mayo Clinic Rochester | Rochester | Minnesota | 55905-0001 | Recruiting |
| Hattiesburg Hematology and Oncology Clinic | Hattiesburg | Mississippi | 39401-7233 | Recruiting |
| Washington University School of Medicine | St Louis | Missouri | 63110-1010 | Recruiting |
| Nebraska Cancer Specialists St Francis Grand Island | Grand Island | Nebraska | 68803 | Recruiting |
| Nebraska Cancer Specialists | Omaha | Nebraska | 68130-2042 | Recruiting |
| The Valley Hospital, Inc | Paramus | New Jersey | 07652 | Recruiting |
| Memorial Sloan Kettering Cancer Center Mskcc | New York | New York | 10065-6800 | Recruiting |
| Atrium Health Levine Cancer Institute (Lci) | Charlotte | North Carolina | 28204-2990 | Recruiting |
| Duke University | Durham | North Carolina | 27710 | Recruiting |
| Atrium Health Wake Forest Baptist | Winston-Salem | North Carolina | 27157 | Recruiting |
| University Hospitals | Cleveland | Ohio | 44106-1716 | Recruiting |
| Cleveland Clinic Foundation | Cleveland | Ohio | 44195-0001 | Recruiting |
| Ohio State University Comprehensive Cancer Center | Columbus | Ohio | 43210-1280 | Recruiting |
| Ohio Health Research Institute | Columbus | Ohio | 43214-3907 | Recruiting |
| Penn State Milton S Hershey Medical Center | Hershey | Pennsylvania | 17033 | Recruiting |
| McGlinn Cancer Institute | West Reading | Pennsylvania | 19611-2143 | Recruiting |
| Tennessee Oncology Nashville St Thomas Midtown Clinic | Nashville | Tennessee | 37205 | Recruiting |
| Tennessee Oncology | Nashville | Tennessee | 37205 | Recruiting |
| Md Anderson Cancer Center | Houston | Texas | 77030-3907 | Recruiting |
| Texas Oncology Austin Midtown | Round Rock | Texas | 78681-4019 | Recruiting |
| University of Virginia | Charlottesville | Virginia | 22908-0817 | Recruiting |
| Virgina Cancer Specialists | Gainesville | Virginia | 20155-3257 | Recruiting |
| Vcu Massey Cancer Center | Richmond | Virginia | 23298-5026 | Recruiting |
| Northwest Cancer Specialist, Pc(Us Oncology Research) | Vancouver | Washington | 98684-6930 | Recruiting |
| University of Wisconsin | Madison | Wisconsin | 53792-0001 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 114 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06742996, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 18, 2026 · Synced Sep 12, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06742996 live on ClinicalTrials.gov.