SUPRAME-ACTengine® IMA203 vs. Investigator's Choice of Treatment in Previously Treated, Unresectable or Metastatic Cutaneous Melanoma

ClinicalTrials.gov ID: NCT06743126

Public ClinicalTrials.gov record NCT06743126. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 5, 2026, 3:16 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Prospective, Multicenter, Open-label, Randomized, Actively Controlled, Parallel-group Phase 3 Clinical Trial to Evaluate Efficacy, Safety, and Tolerability of IMA203 Versus Investigator's Choice of Treatment in Patients With Previously Treated, Unresectable or Metastatic Cutaneous Melanoma (ACTengine® IMA203-301)

Study identification

NCT ID: NCT06743126
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: Immatics US, Inc.; Industry
Enrollment: 360 participants

Conditions and interventions

Conditions

Melanoma, Cutaneous Malignant

Interventions

Albumin-Bound Paclitaxel Drug
Dacarbazine Drug
IMA203 Biological
ipilimumab Biological
lifileucel Biological
nivolumab Biological
nivolumab plus relatlimab Biological
paclitaxel Drug
paclitaxel plus carboplatin Drug
pembrolizumab Biological
temozolomide Drug

Drug · Biological

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Jan 13, 2025
Primary completion: Dec 31, 2027
Completion: Sep 30, 2031
Last update posted: Apr 20, 2026

2025 – 2031

United States locations

U.S. sites: 39
U.S. states: 23
U.S. cities: 34

Facility	City	State	ZIP	Site status
Mayo Clinic	Phoenix	Arizona	85054	Recruiting
Honor Health Research Institute	Scottsdale	Arizona	85258	Recruiting
City of Hope National Medical Center	Duarte	California	91010	Recruiting
UC San Diego Moores Cancer Center	La Jolla	California	92093	Recruiting
UCLA Hematology/Oncology	Los Angeles	California	90024	Recruiting
UCSF Helen Diller Family Comprehensive Cancer Center	San Francisco	California	94143	Recruiting
Stanford Cancer Center	Stanford	California	94305	Recruiting
University of Colorado, Anschutz Medical Campus	Aurora	Colorado	80045	Recruiting
Yale Cancer Center	New Haven	Connecticut	06510	Recruiting
Mayo Clinic Florida	Jacksonville	Florida	32224	Active, not recruiting
University of Miami - Sylvester Comprehensive Cancer Cente	Miami	Florida	33136	Recruiting
Moffitt Cancer Center	Tampa	Florida	33612	Recruiting
University of Chicago Medical Center	Chicago	Illinois	60637	Recruiting
University of MD Greenebaum Comprehensive Cancer Center	Baltimore	Maryland	21201	Recruiting
Massachusetts General Hospital	Boston	Massachusetts	02114	Recruiting
Beth Israel Deaconess Medical Center	Boston	Massachusetts	02215	Recruiting
University of Michigan	Ann Arbor	Michigan	48109	Recruiting
Mayo Clinic	Rochester	Minnesota	55905	Active, not recruiting
University of Nebraska Medical Center	Omaha	Nebraska	68198	Recruiting
Atlantic Health System/Morristown Medical Center	Morristown	New Jersey	07960	Recruiting
Laura and Isaac Perlmutter Cancer Center at NYU Langone Health	New York	New York	10016	Recruiting
Memorial Sloan Kettering Cancer Center	New York	New York	10065	Recruiting
University of Rochester	Rochester	New York	14642	Recruiting
UNC Hospitals, The University of North Carolina at Chapel Hill	Chapel Hill	North Carolina	27599	Recruiting
Cleveland Clinic, Taussig Cancer Institute	Cleveland	Ohio	44195	Recruiting
Ohio State University	Columbus	Ohio	43210	Recruiting
Providence Cancer Institute Franz Clinic	Portland	Oregon	97213	Recruiting
University of Pennsylvania, Abramson Cancer Center	Philadelphia	Pennsylvania	19104	Recruiting
Thomas Jeffersion University, Sidney Kimmel Cancer Center	Philadelphia	Pennsylvania	19107	Recruiting
Fox Chase Cancer Center	Philadelphia	Pennsylvania	19111	Recruiting
UPMC Hillman Cancer Center	Pittsburgh	Pennsylvania	15232	Recruiting
Avera Cancer Institute	Sioux Falls	South Dakota	57105	Recruiting
SCRI Oncology Partners	Nashville	Tennessee	37203	Recruiting
Baylor University	Dallas	Texas	75246	Recruiting
University of Texas Southwestern Medical Center	Dallas	Texas	75390	Recruiting
The University of Texas MD Anderson Cancer Center	Houston	Texas	77030	Recruiting
Huntsman Cancer Institute, University of Utah	Salt Lake City	Utah	84112	Recruiting
Virginia Commonwealth University	Richmond	Virginia	23219	Recruiting
Fred Hutchinson Cancer Center	Seattle	Washington	98109	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 20 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT06743126, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Apr 20, 2026 · Synced May 5, 2026

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The complete protocol, eligibility criteria, and contact information for NCT06743126 live on ClinicalTrials.gov.

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