A Study to Investigate the Efficacy, Safety and Tolerability of Remibrutinib Versus Placebo in Adult Patients With Generalized Myasthenia Gravis

ClinicalTrials.gov ID: NCT06744920

Public ClinicalTrials.gov record NCT06744920. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Sep 11, 2026, 2:00 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Randomized, Double-blind, Placebo-controlled Phase III Study to Evaluate the Efficacy, Safety, and Tolerability of Remibrutinib in Patients With Generalized Myasthenia Gravis, Followed by an Open-label Extension Phase

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

A study to evaluate the efficacy, safety and tolerability of Remibrutinib versus placebo in adult patients with Generalized Myasthenia Gravis who are on stable, standard-of-care (SOC) treatment.

Study identification

NCT ID: NCT06744920
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: Novartis Pharmaceuticals; Industry
Enrollment: 180 participants

Conditions and interventions

Conditions

Generalized Myasthenia Gravis

Interventions

Drug · Other

Eligibility (public fields only)

Age range: 18 Years to 85 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Feb 6, 2025
Primary completion: Feb 24, 2028
Completion: Feb 25, 2033
Last update posted: Jul 28, 2026

2025 – 2033

United States locations

U.S. sites: 24
U.S. states: 14
U.S. cities: 22

Facility	City	State	ZIP	Site status
Neuromuscular Research Center	Phoenix	Arizona	85013	Recruiting
Honor Health Research Institute	Scottsdale	Arizona	85258	Recruiting
Fullerton Neuro and Headache Ctr	Fullerton	California	92835	Recruiting
University Of Southern California	Los Angeles	California	90033	Recruiting
Univ Cali Irvine ALS Neuromuscular	Orange	California	92868	Recruiting
California Pacific Medical Center	Sacramento	California	94115	Recruiting
Medstar Washington Hospital Center	Washington D.C.	District of Columbia	20010-2975	Recruiting
SFM Clinical Research LLC	Boca Raton	Florida	33487	Recruiting
Homestead Assoc In Research Inc	Homestead	Florida	33033	Recruiting
Neurology Associates PA	Maitland	Florida	32751	Recruiting
AdventHealth	Orlando	Florida	32804	Recruiting
Neurological Services of Orlando PA	Orlando	Florida	32806	Recruiting
University of Chicago Medical Centr	Chicago	Illinois	60637	Recruiting
Mid Atlantic Epilepsy and Sleep Ctr	Bethesda	Maryland	20817-1807	Recruiting
Massachusetts General Hospital	Boston	Massachusetts	02114	Recruiting
Michigan State University-Department of Neurology	East Lansing	Michigan	48824	Recruiting
Dent Neurological Institute	Buffalo	New York	14209	Recruiting
Univ of Cincinnati Medical Center	Cincinnati	Ohio	45219	Recruiting
Cleveland Clinic Foundation	Cleveland	Ohio	44195	Recruiting
University of Pittsburgh Medical Center	Pittsburgh	Pennsylvania	15213	Recruiting
Houston Methodist Hospital	Houston	Texas	77030	Recruiting
UT Health Science Center	Houston	Texas	77030	Recruiting
University of WA Division of Cardio	Seattle	Washington	98195	Recruiting
Center for Neurological Disorders G	Greenfield	Wisconsin	53228-1321	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 106 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT06744920, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Jul 28, 2026 · Synced Sep 11, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT06744920 live on ClinicalTrials.gov.

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