ClinicalTrials.gov record
A Study of Amivantamab and FOLFIRI Versus Cetuximab/Bevacizumab and FOLFIRI in Participants With KRAS/NRAS and BRAF Wild-type Colorectal Cancer Who Have Previously Received Chemotherapy
ClinicalTrials.gov ID: NCT06750094
Public ClinicalTrials.gov record NCT06750094. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced May 6, 2026, 5:29 PM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Open-label Phase 3 Study of Amivantamab + FOLFIRI Versus Cetuximab/Bevacizumab + FOLFIRI in Participants With KRAS/NRAS and BRAF Wild-type Recurrent, Unresectable or Metastatic Colorectal Cancer Who Have Received Prior Chemotherapy
Study identification
- NCT ID
- NCT06750094
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Janssen Research & Development, LLC
- Industry
- Enrollment
- 700 participants
Conditions and interventions
Conditions
Interventions
- 5-fluorouracil Drug
- Amivantamab Biological
- Bevacizumab Biological
- Cetuximab Biological
- Irinotecan Drug
- Leucovorin calcium/Levoleucovorin Drug
Drug · Biological
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 11, 2024
- Primary completion
- Dec 14, 2027
- Completion
- Apr 12, 2029
- Last update posted
- Apr 12, 2026
2024 – 2029
United States locations
- U.S. sites
- 65
- U.S. states
- 26
- U.S. cities
- 58
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Ironwood Cancer and Research Center | Chandler | Arizona | 85224 | Recruiting |
| Banner MD Anderson Cancer Center | Gilbert | Arizona | 85234 | Recruiting |
| Arizona Oncology Associates PC NAHOA | Prescott | Arizona | 86301 | Completed |
| St. Bernard's Medical Center | Jonesboro | Arkansas | 72401 | Recruiting |
| Highlands Oncology Group | Springdale | Arkansas | 72762 | Recruiting |
| CBCC Global Research | Bakersfield | California | 93309 | Recruiting |
| Los Angeles Cancer Network | Glendale | California | 91204 | Recruiting |
| Cancer and Blood Specialty Clinic | Los Alamitos | California | 90720 | Recruiting |
| USC Norris Comprehensive Cancer Center | Los Angeles | California | 90033 | Recruiting |
| UCLA | Santa Monica | California | 90404 | Recruiting |
| Providence Medical Foundation | Santa Rosa | California | 95403 | Recruiting |
| Torrance Memorial Physicians Network | Torrance | California | 90505 | Recruiting |
| University of Colorado Denver Anschultz Medical Campus | Aurora | Colorado | 80045 | Recruiting |
| Rocky Mountain Cancer Centers | Denver | Colorado | 80218 | Recruiting |
| Eastern Connecticut Hematology & Oncology Assoc. | Norwich | Connecticut | 06360 | Recruiting |
| Florida Cancer Specialists South | Fort Myers | Florida | 33901 | Recruiting |
| Mount Sinai Medical Center Campus | Miami Beach | Florida | 33140 | Recruiting |
| AdventHealth Cancer Institute | Orlando | Florida | 32804 | Recruiting |
| Florida Cancer Specialists North Region | St. Petersburg | Florida | 33701-4553 | Recruiting |
| Florida Cancer Specialists East | West Palm Beach | Florida | 33401-3406 | Recruiting |
| University Cancer And Blood Center LLC | Athens | Georgia | 30607 | Recruiting |
| Grady Memorial Hospital | Atlanta | Georgia | 30303 | Recruiting |
| Piedmont Cancer Institute | Atlanta | Georgia | 30318 | Recruiting |
| Winship Cancer Institute Emory University | Atlanta | Georgia | 30322 | Recruiting |
| Illinois CancerCare | Peoria | Illinois | 61615 | Recruiting |
| Mission Cancer Blood | Waukee | Iowa | 50263 | Recruiting |
| Cancer Center of Kansas | Wichita | Kansas | 67214 | Recruiting |
| Mary Bird Perkins Cancer Center | Baton Rouge | Louisiana | 70809 | Recruiting |
| MedStar Franklin Square Medical Center | Baltimore | Maryland | 21237 | Recruiting |
| University of Michigan Rogel Cancer Center | Ann Arbor | Michigan | 48109 | Recruiting |
| Henry Ford Hospital | Detroit | Michigan | 48202 | Recruiting |
| Cancer And Hematology Centers of Western Michigan PC | Grand Rapids | Michigan | 49503 | Recruiting |
| Hattiesburg Clinic | Hattiesburg | Mississippi | 39401 | Recruiting |
| Washington University School Of Medicine | St Louis | Missouri | 63110 | Recruiting |
| Nebraska Cancer Specialists | Omaha | Nebraska | 68130 | Recruiting |
| Astera Cancer Care | East Brunswick | New Jersey | 08816 | Recruiting |
| Perlmutter Cancer Center at NYU Long Island | Mineola | New York | 11501 | Recruiting |
| NYU Langone Medical Center NYU Hematology Associates | New York | New York | 10016 | Recruiting |
| New York Cancer and Blood Specialists | Shirley | New York | 11967 | Recruiting |
| Montefiore Einstein Comprehensive Cancer Center | The Bronx | New York | 10461 | Recruiting |
| Gabrail Cancer Center | Canton | Ohio | 44718 | Recruiting |
| University Hospital of Cleveland | Cleveland | Ohio | 44106 | Recruiting |
| Oregon Health And Science University | Portland | Oregon | 97239 | Recruiting |
| Alliance Cancer Specialists at Main Line | Penn Wynne | Pennsylvania | 19096 | Recruiting |
| Thomas Jefferson University | Philadelphia | Pennsylvania | 19107 | Recruiting |
| Fox Chase Cancer Center | Philadelphia | Pennsylvania | 19111 | Recruiting |
| University Of Pittsburgh Medical Center UPMC Hillman Cancer Center | Pittsburgh | Pennsylvania | 15232 1301 | Recruiting |
| Tennessee Oncology Chattanooga | Chattanooga | Tennessee | 37404 | Recruiting |
| SCRI Oncology Partners | Nashville | Tennessee | 37203 | Recruiting |
| Tennessee Oncology | Nashville | Tennessee | 37203 | Recruiting |
| Vanderbilt University Medical Center | Nashville | Tennessee | 37232 | Recruiting |
| Texas Oncology West Texas | Abilene | Texas | 79606 | Recruiting |
| Texas Oncology DFW | Dallas | Texas | 75246 | Recruiting |
| UT Southwestern Medical Center | Dallas | Texas | 75390 | Recruiting |
| MD Anderson Cancer Center | Houston | Texas | 77030 | Recruiting |
| Baylor Scott & White Medical Center | Round Rock | Texas | 77845 | Recruiting |
| Texas Oncology - San Antonio | San Antonio | Texas | 78240 | Recruiting |
| Scott And White Memorial Hospital | Temple | Texas | 76508 | Recruiting |
| UT Health East Texas HOPE Cancer Center | Tyler | Texas | 75701 | Recruiting |
| Virginia Cancer Specialists | Arlington | Virginia | 22201 | Recruiting |
| Richmond VA Medical Center | Richmond | Virginia | 23249 | Recruiting |
| VCU Massey Comprehensive Cancer Center | Richmond | Virginia | 23298 | Recruiting |
| Providence Regional Cancer System | Lacey | Washington | 98503 | Recruiting |
| Fred Hutchinson Cancer Research Center | Seattle | Washington | 98109 | Recruiting |
| Medical College Of Wisconsin | Milwaukee | Wisconsin | 53226 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 169 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06750094, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 12, 2026 · Synced May 6, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06750094 live on ClinicalTrials.gov.