A Study of ORX750 in Participants With Narcolepsy and Idiopathic Hypersomnia
Public ClinicalTrials.gov record NCT06752668. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2a, Randomized, Double-blind, Placebo-controlled Study of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ORX750 in Subjects With Narcolepsy and Idiopathic Hypersomnia (CRYSTAL-1)
Study identification
- NCT ID
- NCT06752668
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- Centessa Pharmaceuticals (UK) Limited
- Industry
- Enrollment
- 248 participants
Conditions and interventions
Interventions
- ORX750 Drug
- Placebo Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years to 65 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 22, 2024
- Primary completion
- Nov 30, 2026
- Completion
- Nov 30, 2026
- Last update posted
- Apr 26, 2026
2024 – 2026
United States locations
- U.S. sites
- 29
- U.S. states
- 14
- U.S. cities
- 27
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Auburn, Alabama | Auburn | Alabama | 36832 | Recruiting |
| Chandler, Arizona | Chandler | Arizona | 85224 | Recruiting |
| Scottsdale, Arizona | Scottsdale | Arizona | 85253 | Recruiting |
| Long Beach, California | Long Beach | California | 90805 | Recruiting |
| Santa Ana, California | Santa Ana | California | 92705 | Recruiting |
| Brandon, Florida | Brandon | Florida | 33511 | Recruiting |
| Miami, Florida | Miami | Florida | 33155 | Recruiting |
| Miami, Florida | Miami | Florida | 33176 | Recruiting |
| Orlando, FL | Orlando | Florida | 32807 | Recruiting |
| Winter Park, Florida | Winter Park | Florida | 32789 | Recruiting |
| Atlanta, Georgia | Atlanta | Georgia | 30281 | Recruiting |
| Atlanta, Georgia | Atlanta | Georgia | 30328 | Recruiting |
| Riverdale, Georgia | Riverdale | Georgia | 30274 | Recruiting |
| New Orleans, Louisiana | New Orleans | Louisiana | 70127 | Recruiting |
| Newton, Massachusetts | Newton | Massachusetts | 02459 | Recruiting |
| Southfield, Michigan | Southfield | Michigan | 48075 | Recruiting |
| Sterling Heights, Michigan | Sterling Heights | Michigan | 48314 | Recruiting |
| Henderson, Nevada | Henderson | Nevada | 89052 | Recruiting |
| Denver, North Carolina | Denver | North Carolina | 28037 | Recruiting |
| Huntersville, North Carolina | Huntersville | North Carolina | 28078 | Recruiting |
| Cincinnati, Ohio | Cincinnati | Ohio | 45245 | Recruiting |
| Cleveland, OH | Cleveland | Ohio | 44106 | Recruiting |
| Dublin, Ohio | Dublin | Ohio | 43017 | Recruiting |
| Willow Grove, Pennsylvania | Willow Grove | Pennsylvania | 19090 | Recruiting |
| Columbia, South Carolina | Columbia | South Carolina | 29201 | Recruiting |
| North Charleston, South Carolina | North Charleston | South Carolina | 29406 | Recruiting |
| Austin, Texas | Austin | Texas | 78731 | Recruiting |
| El Paso, TX | El Paso | Texas | 79912 | Recruiting |
| San Antonio, Texas | San Antonio | Texas | 78229 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 8 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06752668, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 26, 2026 · Synced Apr 29, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06752668 live on ClinicalTrials.gov.