ExCrossV Multi Site Trial for Vascularized High Risk Keratoplasty

ClinicalTrials.gov ID: NCT06753916

Public ClinicalTrials.gov record NCT06753916. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Apr 22, 2026, 11:35 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

Multicenter Clinical Trial to Evaluate the Safety and Efficacy of Ex Vivo Corneal Cross-linking of Donor Corneal Tissue Used for Vascularized High-risk Keratoplasty

Study identification

NCT ID: NCT06753916
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 2
Lead sponsor: Massachusetts Eye and Ear Infirmary; Other
Enrollment: 96 participants

Conditions and interventions

Conditions

Corneal Transplant Failure

Interventions

Corneal Donor Tissue with Cross Linking Procedure
Corneal Donor Tissue without Cross Linking Procedure

Procedure

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Not listed

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Mar 31, 2025
Primary completion: Dec 31, 2027
Completion: Dec 31, 2030
Last update posted: Apr 20, 2026

2025 – 2031

United States locations

U.S. sites: 12
U.S. states: 9
U.S. cities: 12

Facility	City	State	ZIP	Site status
University of California Irvine - Gavin Herbert Eye Institute	Irvine	California	92617	Not yet recruiting
The University of California Los Angeles - Doris Stein Eye Research Center	Los Angeles	California	90095	Not yet recruiting
University of California San Francisco - Wayne and Gladys Valley Center for Vision	San Francisco	California	94158	Not yet recruiting
University of Miami - Bascom Palmer Eye Institute	Miami	Florida	33136	Recruiting
Price Vision Group	Indianapolis	Indiana	46260	Recruiting
Kansas City Eye Clinic	Overland Park	Kansas	66204	Recruiting
Mid-Atlantic Cornea Consultant	Towson	Maryland	21204	Not yet recruiting
Massachusetts Eye and Ear	Boston	Massachusetts	02114	Recruiting
University of Michigan - Kellogg Eye Center	Ann Arbor	Michigan	48015	Recruiting
Wake Forest Baptist Eye Center	Bermuda Run	North Carolina	27006	Not yet recruiting
Duke University - Duke Eye Center	Durham	North Carolina	27705	Recruiting
Cincinnati Eye Institute	Cincinnati	Ohio	45242	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT06753916, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Apr 20, 2026 · Synced Apr 22, 2026

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The complete protocol, eligibility criteria, and contact information for NCT06753916 live on ClinicalTrials.gov.

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