A Trial of Setmelanotide in Patients With Congenital Hypothalamic Obesity (Sub-study of NCT05774756)

ClinicalTrials.gov ID: NCT06760546

Public ClinicalTrials.gov record NCT06760546. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 17, 2026, 11:13 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 3, Double Blind, Randomized, Placebo-Controlled Trial to Evaluate the Efficacy and Safety of Setmelanotide in Patients With Acquired Hypothalamic Obesity

Study identification

NCT ID: NCT06760546
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: Rhythm Pharmaceuticals, Inc.; Industry
Enrollment: 39 participants

Conditions and interventions

Conditions

Interventions

Placebo Drug
Setmelanotide Drug

Drug

Eligibility (public fields only)

Age range: 4 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Sep 22, 2025
Primary completion: Mar 12, 2027
Completion: Mar 12, 2028
Last update posted: Feb 11, 2026

2025 – 2028

United States locations

U.S. sites: 8
U.S. states: 8
U.S. cities: 8

Facility	City	State	ZIP	Site status
University of Alabama	Birmingham	Alabama	35233	Recruiting
Children's Hospital Colorado	Aurora	Colorado	80045	Recruiting
Lurie Children's Hospital	Chicago	Illinois	60611	Recruiting
Boston Children's Hospital	Boston	Massachusetts	02115	Recruiting
Children's Minnesota	Saint Paul	Minnesota	55102	Recruiting
Columbia University Irving Medical Center	New York	New York	10032	Recruiting
Children's Hospital of Philadelphia	Philadelphia	Pennsylvania	19104	Recruiting
Seattle Children's Research Institute	Seattle	Washington	98105	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 3 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT06760546, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Feb 11, 2026 · Synced May 17, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT06760546 live on ClinicalTrials.gov.

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