Clinical Trial Evaluating the Safety and Efficacy of Nucleus Pulposus Allograft in Participants With Degenerative Disc Disease

ClinicalTrials.gov ID: NCT06778447

Public ClinicalTrials.gov record NCT06778447. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Oct 20, 2026, 12:32 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

Randomized, Sham-Controlled, Multi-Center, Double-Blind Clinical Trial Evaluating the Safety and Efficacy of Nucleus Pulposus Allograft to Supplement Nucleus Pulposus Tissue in Participants With Lumbar Discogenic Pain Associated With Degenerative Disc Disease

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

VIA Disc NP is a non-surgical intervention intended to supplement nucleus pulposus tissue in degenerated intervertebral discs. This is a randomized, sham-controlled, multi-center, double-blind clinical trial with an open label roll-in period of one participant per site in which participants with lumbar discogenic pain associated with DDD will receive one VIA Disc NP treatment to each affected level (up to 2 levels). Participants enrolled after the roll-in stage will be randomized on a 2:1 basis to receive either a single VIA Disc NP intradiscal injection at 1 or 2 levels or the sham procedure at 1 or 2 levels. At 12 months, participants in the sham arm with continued symptoms may cross-over, receive VIA Disc NP, and will restart the study visit schedule, completing an additional 12 months of follow-up post-cross-over.

Study identification

NCT ID: NCT06778447
Recruitment status: Recruiting
Study type: Interventional
Phase: Not applicable
Lead sponsor: VIVEX Biologics, Inc.; Industry
Enrollment: 325 participants

Conditions and interventions

Conditions

Interventions

VIA Disc NP Other
Sham Other

Other

Eligibility (public fields only)

Age range: 22 Years to 85 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Feb 17, 2025 (Actual)
Primary completion: Oct 2027 (Estimated)
Completion: Oct 2028 (Estimated)
Last update posted: Sep 14, 2026

2025 – 2028

United States locations

U.S. sites: 19
U.S. states: 15
U.S. cities: 19

Facility	City	State	ZIP	Site status
Interventional Pain Management Napa Valley Orthopedic Medical Group	Napa	California	94558	Recruiting
Source Healthcare	Santa Monica	California	90403	Recruiting
Premier Spine and Pain Institute	Thornton	Colorado	80229	Recruiting
The Orthopaedic Institute	Gainesville	Florida	32607	Recruiting
Georgia Pain Management	Woodstock	Georgia	30189	Recruiting
Henry Community Health	New Castle	Indiana	47362	Recruiting
University of Kansas	Kansas City	Kansas	66160	Recruiting
University of Kentucky	Lexington	Kentucky	40504	Recruiting
Ochsner Clinic Foundation	New Orleans	Louisiana	70115	Recruiting
Spine Institute of Louisiana	Shreveport	Louisiana	71101	Recruiting
Paradigm Health System	Slidell	Louisiana	70458	Recruiting
Nevada Advanced Pain Specialists	Reno	Nevada	89511	Recruiting
Premier Pain Centers	Shrewsbury	New Jersey	07702	Recruiting
Northwell Health	New York	New York	10019	Recruiting
Crystal Coast Pain Management	New Bern	North Carolina	28560	Recruiting
Pacific Sports & Spine	Eugene	Oregon	97404	Recruiting
Procura Pain & Spine	Shenandoah	Texas	77384	Recruiting
Precision Spine Care	Tyler	Texas	75701	Recruiting
The Spine and Nerve Center C/O Clinical Research	Charleston	West Virginia	25301	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT06778447, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Sep 14, 2026 · Synced Oct 20, 2026

Open the official record

The complete public registry record, listed eligibility criteria, and available contact information for NCT06778447 live on ClinicalTrials.gov.

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