Open-label Study Comparing AAA817 Versus Standard of Care in the Treatment of Previously Treated PSMA-positive mCRPC Adults Who Have Disease Progressed on or After [177Lu]Lu-PSMA Targeted Therapy
Public ClinicalTrials.gov record NCT06780670. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
PSMAcTION: A Phase II/III, Open-label, International, Multicenter, Randomized Study of AAA817 Versus Standard of Care in the Treatment of Adult Participants With PSMA Positive Metastatic Castration-resistant Prostate Cancer Who Progressed on or After [177Lu]Lu-PSMA Targeted Therapy
Study identification
- NCT ID
- NCT06780670
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 2, Phase 3
- Lead sponsor
- Novartis Pharmaceuticals
- Industry
- Enrollment
- 443 participants
Conditions and interventions
Conditions
Interventions
- AAA817 Drug
- Investigators choice of SoC Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years to 100 Years
- Sex
- Male
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 26, 2025
- Primary completion
- Jun 26, 2028
- Completion
- Jul 18, 2033
- Last update posted
- Apr 15, 2026
2025 – 2033
United States locations
- U.S. sites
- 14
- U.S. states
- 12
- U.S. cities
- 14
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| VA Greater LA Healthcare System | Los Angeles | California | 90073 | Recruiting |
| Stanford University Medical Center | Palo Alto | California | 94304 | Recruiting |
| University Cancer and Blood Center LLC | Athens | Georgia | 30607 | Recruiting |
| Indiana University | Indianapolis | Indiana | 46202 | Recruiting |
| University of Kansas Hospital | Kansas City | Kansas | 66160 | Recruiting |
| Dana Farber Cancer Institute | Boston | Massachusetts | 02115 | Recruiting |
| WA Uni School Of Med | St Louis | Missouri | 63110 | Recruiting |
| Nebraska Cancer Specialists | Omaha | Nebraska | 68154 | Recruiting |
| New Jersey Urology LLC | Voorhees Township | New Jersey | 08043 | Recruiting |
| Associated Med Professionals of NY | Syracuse | New York | 13210 | Recruiting |
| Montefiore Medical Center | The Bronx | New York | 10467 | Recruiting |
| Carolina Urologic Research Center | Myrtle Beach | South Carolina | 29572 | Recruiting |
| Urology San Antonio | San Antonio | Texas | 78229 | Recruiting |
| Medical College Of Wisconsin | Milwaukee | Wisconsin | 53226 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 47 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06780670, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 15, 2026 · Synced Apr 29, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06780670 live on ClinicalTrials.gov.