A Phase 1b/2a Study of Pocenbrodib as Monotherapy and in Combination With Darolutamide in Participants With mCRPC
Public ClinicalTrials.gov record NCT06785636. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
PATHWAY: A Phase 1b/2a, Multicenter, Open- Label Study of Pocenbrodib as Monotherapy and in Combination With Darolutamide in Participants With Metastatic Castration-Resistant Prostate Cancer (mCRPC)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a dose-finding study to assess the safety and preliminary antitumor activity of Pocenbrodib alone or with darolutamide in patients with metastatic castration-resistant prostate cancer (mCRPC)
Study identification
- NCT ID
- NCT06785636
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 1, Phase 2
- Enrollment
- 120 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- Male
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 6, 2025
- Primary completion
- Jun 29, 2028
- Completion
- Apr 29, 2029
- Last update posted
- Aug 19, 2026
2025 – 2029
United States locations
- U.S. sites
- 19
- U.S. states
- 16
- U.S. cities
- 19
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| MemorialCare Orange Coast Medical Center | Fountain Valley | California | 92708 | Recruiting |
| Cancer and Blood Research Center | Los Alamitos | California | 90720 | Recruiting |
| University of Colorado Health | Aurora | Colorado | 80045 | Recruiting |
| Mount Sinai Medical Center | Miami | Florida | 33140 | Recruiting |
| Emory University Hospital | Atlanta | Georgia | 30322 | Recruiting |
| University of Chicago | Chicago | Illinois | 60637 | Recruiting |
| Community Health Network | Indianapolis | Indiana | 46250 | Recruiting |
| Ochsner | Jefferson | Louisiana | 70121 | Recruiting |
| Johns Hopkins Hospital | Baltimore | Maryland | 21287 | Recruiting |
| Karmanos Cancer Institute | Detroit | Michigan | 48201 | Recruiting |
| Siteman Cancer Center | St Louis | Missouri | 63108 | Recruiting |
| Nebraska Cancer Specialists | Omaha | Nebraska | 68130 | Recruiting |
| Memorial Sloan-Kettering Cancer Center (Mskcc) | New York | New York | 10065 | Recruiting |
| Duke University medical center | Durham | North Carolina | 27710 | Recruiting |
| The Ohio State University | Columbus | Ohio | 43210 | Recruiting |
| Taylor Cancer Research Center | Maumee | Ohio | 43537 | Recruiting |
| University of Texas Southwestern Medical Center | Dallas | Texas | 75390 | Recruiting |
| Oncology Consultants, P.A | Houston | Texas | 77030 | Recruiting |
| NEXT Oncology - Virginia | Fairfax | Virginia | 22031 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06785636, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 19, 2026 · Synced Sep 7, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06785636 live on ClinicalTrials.gov.