A Study Evaluating the Efficacy and Safety of Divarasib and Pembrolizumab Versus Pembrolizumab and Pemetrexed and Carboplatin or Cisplatin in Participants With Previously Untreated, KRAS G12C-Mutated, Advanced or Metastatic Non-Squamous Non-Small Cell Lung Cancer
Public ClinicalTrials.gov record NCT06793215. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase III, Randomized, Open-Label Study Evaluating the Efficacy and Safety of Divarasib and Pembrolizumab Versus Pembrolizumab and Pemetrexed and Carboplatin or Cisplatin in Patients With Previously Untreated, KRAS G12C-Mutated, Advanced or Metastatic Non-Squamous Non-Small Cell Lung Cancer
Study identification
- NCT ID
- NCT06793215
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Hoffmann-La Roche
- Industry
- Enrollment
- 600 participants
Conditions and interventions
Conditions
Interventions
- Carboplatin Drug
- Cisplatin Drug
- Divarasib Drug
- Pembrolizumab Drug
- Pemetrexed Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Not listed
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 23, 2025
- Primary completion
- Nov 29, 2028
- Completion
- Oct 30, 2030
- Last update posted
- Apr 12, 2026
2025 – 2030
United States locations
- U.S. sites
- 35
- U.S. states
- 18
- U.S. cities
- 35
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Alaska Oncology and Hematology | Anchorage | Alaska | 99508 | Recruiting |
| City of Hope - Phoenix | Goodyear | Arizona | 85338 | Recruiting |
| Marin Cancer Care Inc | Greenbrae | California | 94904 | Recruiting |
| Hoag Memorial Hospital | Newport Beach | California | 92658 | Recruiting |
| Florida Cancer Specialists - SOUTH - SCRI - PPDS | Fort Myers | Florida | 33901-8108 | Recruiting |
| BioResearch Partner | Hialeah | Florida | 33013 | Recruiting |
| Ascension Sacred Heart | Pensacola | Florida | 32504 | Recruiting |
| Florida Cancer Specialists - NORTH - SCRI - PPDS | St. Petersburg | Florida | 33701 | Recruiting |
| Florida Cancer Specialists - EAST - SCRI - PPDS | West Palm Beach | Florida | 33401-3406 | Recruiting |
| Piedmont Cancer Institute, PC | Atlanta | Georgia | 30318 | Recruiting |
| City of Hope® Atlanta | Newnan | Georgia | 30265 | Recruiting |
| Summit Cancer Care PC | Savannah | Georgia | 31405 | Recruiting |
| St. Luke's Cancer Institute | Boise | Idaho | 83712 | Recruiting |
| Affiliated Oncologists, LLC | Chicago Ridge | Illinois | 60415 | Recruiting |
| Hope and Healing Cancer Services | Hinsdale | Illinois | 60521 | Withdrawn |
| City of Hope® Cancer Center Chicago | Zion | Illinois | 60099 | Recruiting |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | Recruiting |
| Profound Research, LLC | Farmington Hills | Michigan | 48334 | Recruiting |
| Missouri Baptist Medical Center | St Louis | Missouri | 63131 | Recruiting |
| San Juan Oncology Associates | Farmington | New Mexico | 87401 | Recruiting |
| Montefiore Einstein Cancer Center | The Bronx | New York | 10461 | Recruiting |
| Clinical Research Alliance | Westbury | New York | 11590 | Recruiting |
| Firsthealth of The Carolinas | Pinehurst | North Carolina | 28374 | Recruiting |
| Oregon Health and Science University | Portland | Oregon | 97239 | Recruiting |
| St. Luke's University Health Network | Bethlehem | Pennsylvania | 18015 | Recruiting |
| Reading Hospital - McGlinn Cancer Institute | West Reading | Pennsylvania | 19611 | Recruiting |
| Baptist Cancer Center | Memphis | Tennessee | 38120 | Recruiting |
| Renovatio Clinical - El Paso | El Paso | Texas | 79915 | Recruiting |
| JPS Health Network | Fort Worth | Texas | 76104 | Recruiting |
| The University of Texas MD Anderson Cancer Center | Houston | Texas | 77030-4000 | Recruiting |
| Community Clinical Trials | Kingwood | Texas | 77339 | Recruiting |
| Texas Tech Health Science Center | Lubbock | Texas | 79415 | Recruiting |
| Renovatio Clinical | The Woodlands | Texas | 77380 | Recruiting |
| University of Texas Health Center at Tyler | Tyler | Texas | 75708 | Recruiting |
| Virginia Oncology Associates | Norfolk | Virginia | 23502 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 182 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06793215, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 12, 2026 · Synced Apr 22, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06793215 live on ClinicalTrials.gov.