A Study Evaluating the Efficacy and Safety of Divarasib and Pembrolizumab Versus Pembrolizumab and Pemetrexed and Carboplatin or Cisplatin in Participants With Previously Untreated, KRAS G12C-Mutated, Advanced or Metastatic Non-Squamous Non-Small Cell Lung Cancer

ClinicalTrials.gov ID: NCT06793215

Public ClinicalTrials.gov record NCT06793215. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 20, 2026, 7:17 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase III, Randomized, Open-Label Study Evaluating the Efficacy and Safety of Divarasib and Pembrolizumab Versus Pembrolizumab and Pemetrexed and Carboplatin or Cisplatin in Patients With Previously Untreated, KRAS G12C-Mutated, Advanced or Metastatic Non-Squamous Non-Small Cell Lung Cancer

Study identification

NCT ID: NCT06793215
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: Hoffmann-La Roche; Industry
Enrollment: 600 participants

Conditions and interventions

Conditions

Interventions

Carboplatin Drug
Cisplatin Drug
Divarasib Drug
Pembrolizumab Drug
Pemetrexed Drug

Drug

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Oct 23, 2025
Primary completion: Nov 29, 2028
Completion: Oct 30, 2030
Last update posted: May 10, 2026

2025 – 2030

United States locations

U.S. sites: 44
U.S. states: 21
U.S. cities: 44

Facility	City	State	ZIP	Site status
Alaska Oncology and Hematology	Anchorage	Alaska	99508	Recruiting
City of Hope - Phoenix	Goodyear	Arizona	85338	Recruiting
Marin Cancer Care Inc	Greenbrae	California	94904	Recruiting
Hoag Memorial Hospital	Newport Beach	California	92658	Recruiting
Palo Alto Medical Foundation Research Center	Palo Alto	California	94301	Recruiting
Sutter Institute for Medical Research	Roseville	California	95661	Recruiting
California Pacific Medical Center	San Francisco	California	94115	Recruiting
Florida Cancer Specialists - SOUTH - SCRI - PPDS	Fort Myers	Florida	33901-8108	Recruiting
University of Florida Health at Shands	Gainesville	Florida	32610	Recruiting
BioResearch Partner	Hialeah	Florida	33013	Recruiting
Memorial Healthcare System - Memorial Regional Hospital	Hollywood	Florida	33021	Recruiting
Sylvester Comprehensive Cancer Center	Miami	Florida	33136	Recruiting
Ascension Sacred Heart	Pensacola	Florida	32504	Recruiting
Florida Cancer Specialists - NORTH - SCRI - PPDS	St. Petersburg	Florida	33701	Recruiting
Florida Cancer Specialists - EAST - SCRI - PPDS	West Palm Beach	Florida	33401-3406	Recruiting
Piedmont Cancer Institute, PC	Atlanta	Georgia	30318	Recruiting
City of Hope® Atlanta	Newnan	Georgia	30265	Recruiting
Summit Cancer Care PC	Savannah	Georgia	31405	Recruiting
St. Luke's Cancer Institute	Boise	Idaho	83712	Recruiting
Affiliated Oncologists, LLC	Chicago Ridge	Illinois	60415	Recruiting
Hope and Healing Cancer Services	Hinsdale	Illinois	60521	Withdrawn
City of Hope® Cancer Center Chicago	Zion	Illinois	60099	Recruiting
Saint Agnes Hospital - Baltimore - Hunt - PPDS	Baltimore	Maryland	21229-5201	Recruiting
Massachusetts General Hospital	Boston	Massachusetts	02114	Recruiting
Profound Research, LLC	Farmington Hills	Michigan	48334	Recruiting
Missouri Baptist Medical Center	St Louis	Missouri	63131	Recruiting
NHO Revive Research Institute	Lincoln	Nebraska	68506	Recruiting
San Juan Oncology Associates	Farmington	New Mexico	87401	Recruiting
Montefiore Einstein Cancer Center	The Bronx	New York	10461	Recruiting
Clinical Research Alliance	Westbury	New York	11590	Recruiting
Firsthealth of The Carolinas	Pinehurst	North Carolina	28374	Recruiting
Ohio State University	Columbus	Ohio	43210	Recruiting
Oregon Health and Science University	Portland	Oregon	97239	Recruiting
St. Luke's University Health Network	Bethlehem	Pennsylvania	18015	Recruiting
Reading Hospital - McGlinn Cancer Institute	West Reading	Pennsylvania	19611	Recruiting
Baptist Cancer Center	Memphis	Tennessee	38120	Recruiting
Renovatio Clinical - El Paso	El Paso	Texas	79915	Recruiting
JPS Health Network	Fort Worth	Texas	76104	Recruiting
The University of Texas MD Anderson Cancer Center	Houston	Texas	77030-4000	Recruiting
Community Clinical Trials	Kingwood	Texas	77339	Recruiting
Texas Tech Health Science Center	Lubbock	Texas	79415	Recruiting
Renovatio Clinical	The Woodlands	Texas	77380	Recruiting
University of Texas Health Center at Tyler	Tyler	Texas	75708	Recruiting
Virginia Oncology Associates	Norfolk	Virginia	23502	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 196 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT06793215, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted May 10, 2026 · Synced May 20, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT06793215 live on ClinicalTrials.gov.

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