Lp(a) Lowering Study of Pelacarsen (TQJ230) With Background Inclisiran in Participants With Elevated Lp(a) and Established ASCVD
Public ClinicalTrials.gov record NCT06813911. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Double-blind, Placebo-controlled, Multicenter Study to Evaluate the Efficacy, Safety, and Tolerability of Pelacarsen (TQJ230) With Background Inclisiran in Participants With Atherosclerotic Cardiovascular Disease (ASCVD), and Elevated LDL-C and Lp(a)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of the study CTQJ230A12304, is to evaluate the efficacy, safety, and tolerability of pelacarsen (TQJ230) compared to placebo in participants with ASCVD who have elevated lipoprotein(a) (Lp(a)), and who are on background inclisiran treatment for elevated low-density lipoprotein cholesterol (LDL-C). Study has been terminated by sponsor following the outcome of the Lp(a)HORIZON study (NCT04023552), which did not meet its primary endpoint
Study identification
- NCT ID
- NCT06813911
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 246 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 18 Years to 80 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Apr 30, 2025 (Actual)
- Primary completion
- Feb 3, 2028 (Estimated)
- Completion
- Feb 29, 2028 (Estimated)
- Last update posted
- Oct 14, 2026
2025 – 2028
United States locations
- U.S. sites
- 35
- U.S. states
- 17
- U.S. cities
- 34
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Parkway Medical Center | Birmingham | Alabama | 35215 | — |
| Clinical Research Inst of Arizona | Sun City West | Arizona | 85375 | — |
| National Heart Institute | Beverly Hills | California | 90211 | — |
| Interv Cardiology Med Grp | West Hills | California | 91307 | — |
| Excel Medical Clinical Trials LLC | Boca Raton | Florida | 33434 | — |
| Jacksonville Center for Clinical | Jacksonville | Florida | 32216 | — |
| K2 Medical Research LLC | Maitland | Florida | 32751 | — |
| University of Miami Hospital | Miami | Florida | 33136 | — |
| Baptist Health South | Miami | Florida | 33173 | — |
| Inpatient Research Clinical LLC | Miami Lakes | Florida | 33014 | — |
| FXM Clin Res Miramar LLC | Miramar | Florida | 33027 | — |
| Ocala Cardiovascular Research | Ocala | Florida | 34471 | — |
| SEC Clinical Research | Pensacola | Florida | 32503 | — |
| Peace River Cardiovascular Center | Port Charlotte | Florida | 33952 | — |
| University Of South Florida | Tampa | Florida | 33612 | — |
| FC Site Partners Miami | Winter Park | Florida | 32789 | — |
| Advocate Lutheran General Childrens Hospital | Park Ridge | Illinois | 60068 | — |
| American Health Network Research Dept | Muncie | Indiana | 47304 | — |
| Cardiovascular Associates Research | Covington | Louisiana | 70433 | — |
| Omega Clinical Research | Metairie | Louisiana | 70006 | — |
| Flourish Research Bowie | Bowie | Maryland | 20715 | — |
| Anderson Medical Research | Ft. Washington | Maryland | 20744 | — |
| Henry Ford Hospital | Detroit | Michigan | 48202 | — |
| Aa Mrc Llc | Flint | Michigan | 48504 | — |
| MyMichigan Medical Center Midland | Midland | Michigan | 48670 | — |
| AB Clinical Trials | Las Vegas | Nevada | 89119 | — |
| Overlook Medical Center | Summit | New Jersey | 07901 | — |
| Wake Forest University Baptist Medical Center | Winston-Salem | North Carolina | 27157 | — |
| The Corvallis Clinic P C | Corvallis | Oregon | 97330 | — |
| Novartis Investigative Site | Tullahoma | Tennessee | 37388 | — |
| PharmaTex Research LLC | Amarillo | Texas | 79106 | — |
| Kelsey Seybold Research Foundation | Houston | Texas | 77030 | — |
| Northwest Houston Clinical Research PLLC | Tomball | Texas | 77375 | — |
| Intermountain Medical Center | Murray | Utah | 84107 | — |
| Virginia Heart | Falls Church | Virginia | 22042 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 59 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06813911, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 14, 2026 · Synced Oct 28, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06813911 live on ClinicalTrials.gov.