ClinicalTrials.gov record
A Study to Assess the Efficacy and Safety of Induction Therapy With Afimkibart (RO7790121) in Participants With Moderately to Severely Active Crohn's Disease
ClinicalTrials.gov ID: NCT06819891
Public ClinicalTrials.gov record NCT06819891. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced May 8, 2026, 3:54 AM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase III, Multicenter, Double-Blind, Placebo-Controlled Study to Assess the Efficacy and Safety of Induction Therapy With RO7790121 in Patients With Moderately to Severely Active Crohn's Disease
Study identification
- NCT ID
- NCT06819891
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Hoffmann-La Roche
- Industry
- Enrollment
- 425 participants
Conditions and interventions
Conditions
Interventions
- Afimkibart Drug
- Placebo Drug
Drug
Eligibility (public fields only)
- Age range
- 16 Years to 80 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 11, 2025
- Primary completion
- Dec 30, 2028
- Completion
- Apr 29, 2033
- Last update posted
- May 6, 2026
2025 – 2033
United States locations
- U.S. sites
- 46
- U.S. states
- 18
- U.S. cities
- 44
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Sun City Clinical Research | Glendale | Arizona | 85304 | Recruiting |
| Om Research LLC | Lancaster | California | 93534 | Recruiting |
| Hoag Memorial Hospital Presbyterian;Hoag Center for Research and Education | Newport Beach | California | 92663 | Recruiting |
| Empire Clinical Research | Pomona | California | 91767 | Withdrawn |
| Stanford Medicine Outpatient Center | Redwood City | California | 94063 | Recruiting |
| Clinical Applications Laboratories, Inc. | San Diego | California | 92103 | Recruiting |
| Amicis Research Center | Santa Clarita | California | 91355 | Recruiting |
| Peak Gastroenterology Associates | Colorado Springs | Colorado | 80907 | Recruiting |
| J&A Clinical Research | Doral | Florida | 33126 | Recruiting |
| Homestead Associates in Research, Inc. | Miami | Florida | 33033 | Recruiting |
| Allied Biomedical Research Institute, Inc | Miami | Florida | 33155 | Recruiting |
| Rejuvaline Medical Research | Miami | Florida | 33155 | Recruiting |
| Miami Beach Clinical Research Center | Miami Beach | Florida | 33141 | Recruiting |
| Eminat Research Group | Miramar | Florida | 33027 | Recruiting |
| Digestive and Liver Center of Florida | Orlando | Florida | 32825 | Recruiting |
| Advanced Medical Research Center | Port Orange | Florida | 32127 | Recruiting |
| Santos Research Center, CORP | Tampa | Florida | 33615 | Recruiting |
| Cleveland Clinic Florida | Weston | Florida | 33331 | Recruiting |
| The University of Chicago | Chicago | Illinois | 60637 | Recruiting |
| Robley Rex VA Medical Center | Louisville | Kentucky | 40206 | Recruiting |
| Baton Rouge General Medical Center | Baton Rouge | Louisiana | 70809 | Recruiting |
| Louisiana Research Center - GastroIntestinal Associates | Shreveport | Louisiana | 71105 | Recruiting |
| Mercy Medical Center | Baltimore | Maryland | 21202 | Recruiting |
| Chevy Chase Clinical Research | Chevy Chase | Maryland | 20815 | Recruiting |
| University of Massachusetts Memorial Medical Center | North Worcester | Massachusetts | 01655 | Recruiting |
| Gastroenterology Associates of Western Michigan, P.L.C. | Wyoming | Michigan | 49519 | Recruiting |
| Gastrointestinal Associates Research | Flowood | Mississippi | 39232 | Recruiting |
| Virtua Crohns and Colitis Center | Moorestown | New Jersey | 08057 | Recruiting |
| Robert Wood Johnson University Hospital | New Brunswick | New Jersey | 08901 | Recruiting |
| Ellipsis Research Group | Brooklyn | New York | 11215 | Recruiting |
| Intercity Gastroenterology | Fresh Meadows | New York | 11366 | Recruiting |
| James J Peters Veterans Affairs Medical Center | The Bronx | New York | 10468 | Recruiting |
| Digestive Disease Medicine of Central New York | Utica | New York | 13502 | Recruiting |
| Charlotte Gastroenterology and Hepatology, P.L.L.C | Charlotte | North Carolina | 28207 | Recruiting |
| Clinical Inquest Center | Beavercreek | Ohio | 45431 | Recruiting |
| Cleveland Clinic Foundation | Cleveland | Ohio | 44195 | Recruiting |
| Vanderbilt University Medical Center | Nashville | Tennessee | 37212-1375 | Recruiting |
| University of Texas Southwestern Medical Center - Multidisciplinary Spine Clinic - James W. Aston Ambulatory Care Center | Dallas | Texas | 75390-8565 | Recruiting |
| GI Alliance - Fort Worth | Fort Worth | Texas | 76104 | Recruiting |
| GI Alliance | Garland | Texas | 75044 | Recruiting |
| Integrity Advanced Therapeutics PLLC | Houston | Texas | 77090 | Recruiting |
| Texas Digestive Disease Consultants-Lubbock powered by GI Alliance | Lubbock | Texas | 79410 | Recruiting |
| Carta - Clinical Associates In Research Therapeutics Of America;LLC | San Antonio | Texas | 78212 | Recruiting |
| University of Texas Health Center at Tyler | Tyler | Texas | 75708 | Recruiting |
| TDDC GI Alliance research Webster | Webster | Texas | 77598 | Recruiting |
| University Physicians and Surgeons Inc, dba Marshall Health | Huntington | West Virginia | 25701 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 127 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06819891, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 6, 2026 · Synced May 8, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06819891 live on ClinicalTrials.gov.