Long-Term Safety and Efficacy of Plozasiran in Adults With Hypertriglyceridemia

ClinicalTrials.gov ID: NCT06822790

Public ClinicalTrials.gov record NCT06822790. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 20, 2026, 1:31 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 3 Open-Label Extension Study to Evaluate the Long-Term Safety and Efficacy of Plozasiran in Adults With Hypertriglyceridemia (SHASTA-10 Study)

Study identification

NCT ID: NCT06822790
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: Arrowhead Pharmaceuticals; Industry
Enrollment: 869 participants

Conditions and interventions

Conditions

Hypertriglyceridemia

Interventions

Plozasiran Injection Drug

Drug

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Apr 8, 2025
Primary completion: Jun 30, 2028
Completion: Jun 30, 2028
Last update posted: May 7, 2026

2025 – 2028

United States locations

U.S. sites: 72
U.S. states: 21
U.S. cities: 59

Facility	City	State	ZIP	Site status
Research Site 21	Bakersfield	California	93311	Recruiting
Research Site 9	Beverly Hills	California	90211	Recruiting
Research Site 11	Canoga Park	California	91303	Recruiting
Research Site 40	Garden Grove	California	92844	Recruiting
Research Site 235	Huntington Beach	California	92648	Recruiting
Research Site 236	Lake Forest	California	92630	Recruiting
Research Site 39	Lincoln	California	95648	Recruiting
Research Site 34	Oxnard	California	93030	Recruiting
Research Site 229	Palm Springs	California	92262	Recruiting
Research Site 155	Fort Lauderdale	Florida	33308	Recruiting
Research Site 14	Hialeah	Florida	33016	Recruiting
Research Site 154	Miami	Florida	33144	Recruiting
Research Site 1	Miami Lakes	Florida	33014	Recruiting
Research Site 162	Mt. Dora	Florida	32757	Recruiting
Research Site 42	Mt. Dora	Florida	32757	Recruiting
Research Site 38	North Miami	Florida	33162	Recruiting
Research Site 159	Orlando	Florida	32825	Recruiting
Research Site 41	Orlando	Florida	32825	Recruiting
Research Site 16	Tamarac	Florida	33321	Recruiting
Research Site 18	Tampa	Florida	33614	Recruiting
Research Site 237	Lawrenceville	Georgia	30044	Recruiting
Research Site 17	Park Ridge	Illinois	60068	Recruiting
Research Site 167	Elkhart	Indiana	46514-2487	Recruiting
Research Site 43	Elkhart	Indiana	46514	Recruiting
Research Site 157	Indianapolis	Indiana	46290	Recruiting
Research Site 28	Overland Park	Kansas	66211	Recruiting
Research Site 23	Topeka	Kansas	66606	Recruiting
Research Site 12	Annapolis	Maryland	21401	Recruiting
Research Site 166	Baltimore	Maryland	21229	Recruiting
Research Site 44	Baltimore	Maryland	21229	Recruiting
Research Site 30	Flint	Michigan	48532	Recruiting
Research Site 33	Jackson	Mississippi	39202	Recruiting
Research Site 32	Olive Branch	Mississippi	38654	Recruiting
Research Site 2	Jefferson City	Missouri	65109	Recruiting
Research Site 232	St Louis	Missouri	63136	Recruiting
Research Site 29	Fremont	Nebraska	68025	Recruiting
Research Site 3	Omaha	Nebraska	68144	Recruiting
Research Site 165	Summit	New Jersey	07901	Recruiting
Research Site 77	Summit	New Jersey	07901	Recruiting
Research Site 156	Long Island City	New York	11106	Recruiting
Research Site 72	Long Island City	New York	11106	Recruiting
Research Site 233	New York	New York	10016	Recruiting
Research Site 228	New York	New York	10029	Recruiting
Research Site 37	Asheboro	North Carolina	27203	Recruiting
Research Site 36	Morehead City	North Carolina	28557	Recruiting
Research Site 169	Wilmington	North Carolina	28401	Recruiting
Research Site 22	Beavercreek	Ohio	45431	Recruiting
Research Site 234	Columbus	Ohio	43214	Recruiting
Research Site 164	Norman	Oklahoma	73072	Recruiting
Research Site 76	Norman	Oklahoma	73072	Recruiting
Research Site 31	Oklahoma City	Oklahoma	73112	Recruiting
Research Site 26	Horsham	Pennsylvania	19044	Recruiting
Research Site 8	Newport	Pennsylvania	17074	Recruiting
Research Site 231	Philadelphia	Pennsylvania	19104	Recruiting
Research Site 238	Fort Mill	South Carolina	29707	Recruiting
Research Site 27	El Paso	Texas	19044	Recruiting
Research Site 160	Fort Worth	Texas	76132	Recruiting
Research Site 158	Houston	Texas	77061	Recruiting
Research Site 73	Houston	Texas	77061	Recruiting
Research Site 163	Houston	Texas	77090	Recruiting
Research Site 75	Houston	Texas	77090	Recruiting
Research Site 24	Houston	Texas	77095	Recruiting
Research Site 230	Missouri City	Texas	77459	Recruiting
Research Site 161	Plano	Texas	75093	Recruiting
Research Site 74	Plano	Texas	75093	Recruiting
Research Site 168	San Antonio	Texas	78230	Recruiting
Research Site 13	Sugar Land	Texas	77479	Recruiting
Research Site 170	Tomball	Texas	77375	Recruiting
Research Site 25	Victoria	Texas	77901	Recruiting
Research Site 15	Bountiful	Utah	84010	Recruiting
Research Site 35	St. George	Utah	84790	Recruiting
Research Site 10	Manassas	Virginia	20110	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 176 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT06822790, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted May 7, 2026 · Synced May 20, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT06822790 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →