Dose-Ranging Safety, Tolerability, and Efficacy Study of AZD2373 in Participants With APOL1-Mediated Kidney Disease

ClinicalTrials.gov ID: NCT06824987

Public ClinicalTrials.gov record NCT06824987. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 6, 2026, 12:51 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

Phase 2b Multicentre, Randomized, Double-Blind, Placebo-Controlled, Parallel Group Dose-Ranging Study to Assess the Efficacy, Safety, and Tolerability of AZD2373 in Participants With APOL1-Mediated Kidney Disease (APPRECIATE)

Study identification

NCT ID: NCT06824987
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 2
Lead sponsor: AstraZeneca; Industry
Enrollment: 96 participants

Conditions and interventions

Conditions

APOL1-Mediated Kidney Disease

Interventions

APOL1 Genotyping Clinical Trial Assay Device
AZD2373-Arm 1 Combination Product
AZD2373-Arm 2 Combination Product
Placebo Combination Product

Device · Combination Product

Eligibility (public fields only)

Age range: 18 Years to 65 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Mar 4, 2025
Primary completion: Aug 29, 2027
Completion: Aug 29, 2027
Last update posted: Oct 28, 2025

2025 – 2027

United States locations

U.S. sites: 67
U.S. states: 19
U.S. cities: 60

Facility	City	State	ZIP	Site status
Research Site	Alabaster	Alabama	35007	Recruiting
Research Site	Birmingham	Alabama	35205	Recruiting
Research Site	Irondale	Alabama	35210	Recruiting
Research Site	Beverly Hills	California	90211	Recruiting
Research Site	Gardena	California	90247	Recruiting
Research Site	Los Angeles	California	90095	Not yet recruiting
Research Site	Valencia	California	91355	Recruiting
Research Site	Brandon	Florida	33511	Recruiting
Research Site	Miami	Florida	33126	Recruiting
Research Site	Miami	Florida	33173	Recruiting
Research Site	Orlando	Florida	32808	Recruiting
Research Site	Pompano Beach	Florida	33060	Recruiting
Research Site	Atlanta	Georgia	30322	Not yet recruiting
Research Site	Augusta	Georgia	30909	Recruiting
Research Site	Augusta	Georgia	30912	Not yet recruiting
Research Site	Columbus	Georgia	31901	Recruiting
Research Site	Columbus	Georgia	31904	Recruiting
Research Site	Duluth	Georgia	30096	Recruiting
Research Site	Hinesville	Georgia	31313	Recruiting
Research Site	Lawrenceville	Georgia	30046	Recruiting
Research Site	Macon	Georgia	31210	Recruiting
Research Site	Macon	Georgia	31217	Recruiting
Research Site	Marietta	Georgia	30067	Recruiting
Research Site	Savannah	Georgia	31406	Recruiting
Research Site	Stockbridge	Georgia	30281	Recruiting
Research Site	Chicago	Illinois	60612	Not yet recruiting
Research Site	Hinsdale	Illinois	60521	Recruiting
Research Site	Lafayette	Louisiana	70508	Recruiting
Research Site	New Orleans	Louisiana	70112	Recruiting
Research Site	Bethesda	Maryland	20889	Recruiting
Research Site	Potomac	Maryland	20854	Recruiting
Research Site	Boston	Massachusetts	02114	Not yet recruiting
Research Site	Roseville	Michigan	48066	Recruiting
Research Site	Minneapolis	Minnesota	55455	Not yet recruiting
Research Site	Tupelo	Mississippi	38801	Recruiting
Research Site	Brooklyn	New York	11203	Recruiting
Research Site	Brooklyn	New York	11221	Recruiting
Research Site	Laurelton	New York	11413	Recruiting
Research Site	New York	New York	10010	Not yet recruiting
Research Site	Cary	North Carolina	27511	Recruiting
Research Site	Durham	North Carolina	27705	Not yet recruiting
Research Site	Fayetteville	North Carolina	28304	Recruiting
Research Site	Gastonia	North Carolina	28054	Recruiting
Research Site	Greenville	North Carolina	27834	Recruiting
Research Site	Jacksonville	North Carolina	28546	Recruiting
Research Site	Kinston	North Carolina	28501	Recruiting
Research Site	Winston-Salem	North Carolina	27103	Recruiting
Research Site	Winston-Salem	North Carolina	27157	Recruiting
Research Site	Cincinnati	Ohio	45246	Recruiting
Research Site	Columbus	Ohio	43210	Recruiting
Research Site	Philadelphia	Pennsylvania	19104	Not yet recruiting
Research Site	Anderson	South Carolina	29621	Recruiting
Research Site	Columbia	South Carolina	29203	Recruiting
Research Site	Orangeburg	South Carolina	29118	Recruiting
Research Site	Spartanburg	South Carolina	29306	Recruiting
Research Site	Chattanooga	Tennessee	37404	Not yet recruiting
Research Site	Nashville	Tennessee	37232	Recruiting
Research Site	Conroe	Texas	77384	Not yet recruiting
Research Site	Dallas	Texas	75234	Recruiting
Research Site	Dallas	Texas	75235	Recruiting
Research Site	Houston	Texas	77054	Recruiting
Research Site	Mesquite	Texas	75149	Recruiting
Research Site	Pearland	Texas	77584	Recruiting
Research Site	San Antonio	Texas	78212	Recruiting
Research Site	Alexandria	Virginia	22311	Withdrawn
Research Site	Norfolk	Virginia	23510	Not yet recruiting
Research Site	Richmond	Virginia	23298	Not yet recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 10 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT06824987, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Oct 28, 2025 · Synced May 6, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT06824987 live on ClinicalTrials.gov.

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