Dose-Ranging Safety, Tolerability, and Efficacy Study of AZD2373 in Participants With APOL1-Mediated Kidney Disease
Public ClinicalTrials.gov record NCT06824987. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Phase 2b Multicentre, Randomized, Double-Blind, Placebo-Controlled, Parallel Group Dose-Ranging Study to Assess the Efficacy, Safety, and Tolerability of AZD2373 in Participants With APOL1-Mediated Kidney Disease (APPRECIATE)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to assess the efficacy and safety of AZD2373 in participants diagnosed with APOL1-Mediated Kidney Disease (AMKD) who are homozygotes or compound heterozygotes for APOL1 high-risk genotypes (G1 and G2). The primary hypothesis to be evaluated is that AZD2373, compared with placebo, will result in a greater reduction in UACR as assessed by the relative change from Baseline in UACR at Week 30.
Study identification
- NCT ID
- NCT06824987
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 63 participants
Conditions and interventions
Conditions
Interventions
- AZD2373-Arm 1 Combination Product
- AZD2373-Arm 2 Combination Product
- Placebo Combination Product
- APOL1 Genotyping Clinical Trial Assay Device
Combination Product · Device
Eligibility (public fields only)
- Age range
- 18 Years to 65 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 5, 2025 (Actual)
- Primary completion
- Oct 4, 2027 (Estimated)
- Completion
- Oct 4, 2027 (Estimated)
- Last update posted
- Oct 13, 2026
2025 – 2027
United States locations
- U.S. sites
- 86
- U.S. states
- 20
- U.S. cities
- 76
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Research Site | Alabaster | Alabama | 35007 | — |
| Research Site | Birmingham | Alabama | 35205 | — |
| Research Site | Irondale | Alabama | 35210 | — |
| Research Site | Surprise | Arizona | 85374 | — |
| Research Site | Beverly Hills | California | 90211 | — |
| Research Site | Concord | California | 94520 | — |
| Research Site | Fremont | California | 94538 | — |
| Research Site | Gardena | California | 90247 | — |
| Research Site | Los Angeles | California | 90095 | — |
| Research Site | Valencia | California | 91355 | — |
| Research Site | Boca Raton | Florida | 33487 | — |
| Research Site | Brandon | Florida | 33511 | — |
| Research Site | Miami | Florida | 33126 | — |
| Research Site | Miami | Florida | 33173 | — |
| Research Site | Orlando | Florida | 32808 | — |
| Research Site | Pompano Beach | Florida | 33060 | — |
| Research Site | Atlanta | Georgia | 30322 | — |
| Research Site | Augusta | Georgia | 30904 | — |
| Research Site | Augusta | Georgia | 30909 | — |
| Research Site | Augusta | Georgia | 30912 | — |
| Research Site | Columbus | Georgia | 31901 | — |
| Research Site | Columbus | Georgia | 31904 | — |
| Research Site | Duluth | Georgia | 30096 | — |
| Research Site | Hinesville | Georgia | 31313 | — |
| Research Site | Lawrenceville | Georgia | 30046 | — |
| Research Site | Macon | Georgia | 31210 | — |
| Research Site | Macon | Georgia | 31217 | — |
| Research Site | Marietta | Georgia | 30067 | — |
| Research Site | Savannah | Georgia | 31406 | — |
| Research Site | Stockbridge | Georgia | 30281 | — |
| Research Site | Chicago | Illinois | 60612 | — |
| Research Site | Chicago | Illinois | 60643 | — |
| Research Site | Hinsdale | Illinois | 60521 | — |
| Research Site | Rockford | Illinois | 61107 | — |
| Research Site | Baton Rouge | Louisiana | 70808 | — |
| Research Site | Lafayette | Louisiana | 70508 | — |
| Research Site | New Orleans | Louisiana | 70112 | — |
| Research Site | Shreveport | Louisiana | 71103 | — |
| Research Site | Bethesda | Maryland | 20889 | — |
| Research Site | Potomac | Maryland | 20854 | — |
| Research Site | Boston | Massachusetts | 02114 | — |
| Research Site | Worcester | Massachusetts | 01608 | — |
| Research Site | Lansing | Michigan | 48911 | — |
| Research Site | Roseville | Michigan | 48066 | — |
| Research Site | Minneapolis | Minnesota | 55455 | — |
| Research Site | Columbus | Mississippi | 39705 | — |
| Research Site | Tupelo | Mississippi | 38801 | — |
| Research Site | Brooklyn | New York | 11203 | — |
| Research Site | Brooklyn | New York | 11221 | — |
| Research Site | Laurelton | New York | 11413 | — |
| Research Site | New York | New York | 10010 | — |
| Research Site | Rockville Centre | New York | 11570 | — |
| Research Site | The Bronx | New York | 10461 | — |
| Research Site | Cary | North Carolina | 27511 | — |
| Research Site | Durham | North Carolina | 27705 | — |
| Research Site | Fayetteville | North Carolina | 28304 | — |
| Research Site | Gastonia | North Carolina | 28054 | — |
| Research Site | Greenville | North Carolina | 27834 | — |
| Research Site | Jacksonville | North Carolina | 28546 | — |
| Research Site | Kinston | North Carolina | 28501 | — |
| Research Site | Winston-Salem | North Carolina | 27103 | — |
| Research Site | Winston-Salem | North Carolina | 27157 | — |
| Research Site | Cincinnati | Ohio | 45246 | — |
| Research Site | Columbus | Ohio | 43210 | — |
| Research Site | Bridgeville | Pennsylvania | 15017 | — |
| Research Site | Butler | Pennsylvania | 16001 | — |
| Research Site | Exton | Pennsylvania | 19341 | — |
| Research Site | Philadelphia | Pennsylvania | 19104 | — |
| Research Site | Anderson | South Carolina | 29621 | — |
| Research Site | Columbia | South Carolina | 29203 | — |
| Research Site | Orangeburg | South Carolina | 29118 | — |
| Research Site | Spartanburg | South Carolina | 29306 | — |
| Research Site | Chattanooga | Tennessee | 37404 | — |
| Research Site | Nashville | Tennessee | 37232 | — |
| Research Site | Conroe | Texas | 77304 | — |
| Research Site | Conroe | Texas | 77384 | — |
| Research Site | Dallas | Texas | 75234 | — |
| Research Site | Dallas | Texas | 75235 | — |
| Research Site | Houston | Texas | 77054 | — |
| Research Site | Katy | Texas | 77450 | — |
| Research Site | Mesquite | Texas | 75149 | — |
| Research Site | Pearland | Texas | 77584 | — |
| Research Site | San Antonio | Texas | 78212 | — |
| Research Site | Norfolk | Virginia | 23510 | — |
| Research Site | Portsmouth | Virginia | 23708 | — |
| Research Site | Richmond | Virginia | 23298 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 10 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06824987, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 13, 2026 · Synced Oct 25, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06824987 live on ClinicalTrials.gov.