Phase 1/2: CD45RA Depleted Stem Cell Addback to Prevent Viral or Fungal Infections Post TCRab/CD19 Depleted HSCT
Public ClinicalTrials.gov record NCT06839456. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Phase 1/2 Study: CD45RA Depleted Peripheral Stem Cell Addback to Prevent Viral and Fungal Infections Following Alternative Donor TCRab/CD19 Depleted Hematopoietic Stem Cell Transplant
Study identification
- NCT ID
- NCT06839456
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 1, Phase 2
- Lead sponsor
- Children's Hospital of Philadelphia
- Other
- Enrollment
- 100 participants
Conditions and interventions
Conditions
- Acquired Aplastic Anemia
- Bone Marrow Failure
- HLH
- Hemoglobinopathies
- High Risk Acute Lymphoblastic Leukemia
- High Risk Acute Myeloid Leukemia
- Immunodeficiency
- Inborn Errors of Metabolism
- Inherited BMF Syndrome
- Leukemia
- MDS (Myelodysplastic Syndrome)
- Primary Immune Regulatory Disorder
- Relapse Leukemia
- Relapsed Non-Hodgkin Lymphoma
Interventions
- Phase 1 Dose Level 1 Device
- Phase 1 Dose Level 2 Device
- Phase 1 Dose Level 3 Device
- Phase 2 Established Dose from prior study, NCT03810196 Device
- Phase 2 Maximum Tolerated Dose determined in Phase 1 Device
Device
Eligibility (public fields only)
- Age range
- 1 Month to 25 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 20, 2025
- Primary completion
- Feb 28, 2031
- Completion
- Feb 29, 2032
- Last update posted
- Apr 14, 2026
2025 – 2032
United States locations
- U.S. sites
- 1
- U.S. states
- 1
- U.S. cities
- 1
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Children's Hospital of Philadelphia | Philadelphia | Pennsylvania | 19104 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06839456, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 14, 2026 · Synced May 21, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06839456 live on ClinicalTrials.gov.