Study to Assess Adverse Events and Change in Disease Activity When Oral ABBV-932 is Added to Antidepressant Therapies in Adult Participants With Generalized Anxiety Disorder
Public ClinicalTrials.gov record NCT06846320. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Fixed-Dose Study to Evaluate the Efficacy, Safety, and Tolerability of ABBV-932 as an Adjunct to Antidepressant Therapies in the Treatment of Subjects With Generalized Anxiety Disorder Who Have Had an Inadequate Response to Antidepressant Therapies
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Generalized anxiety disorder (GAD) is usually treated with antidepressant therapy (ADT); however, sometimes ADTs alone are not enough to adequately treat GAD. The purpose of this study is to assess how safe and effective ABBV-932 is when added to the antidepressant therapies in adult participants with GAD who have had an inadequate response ADTs. ABBV-932 is an investigational drug being developed for the adjunctive treatment of GAD. Participants will be randomly assigned to receive ABBV-932 or Placebo in addition to their currently prescribed ADTs. There is 1 in 3 chance of participants assigned to Placebo. Approximately 315 adult participants with GAD and inadequate response to ADTs will be enrolled in approximately 50 sites in the United States and Puerto Rico. Participants will receive oral capsules of ABBV-932 or matching placebo in addition to their prescribed ADT for 6 weeks and then will be followed for an additional 4 week follow-up period. There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at a hospital or clinic. The effect of the treatment will be checked by medical assessments, blood tests, checking for side effects and completing questionnaires.
Study identification
- NCT ID
- NCT06846320
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 315 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 65 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Apr 28, 2025
- Primary completion
- Oct 31, 2026
- Completion
- Oct 31, 2026
- Last update posted
- Jun 16, 2026
2025 – 2026
United States locations
- U.S. sites
- 49
- U.S. states
- 22
- U.S. cities
- 46
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama - Huntsville Regional Medical Campus /ID# 267818 | Huntsville | Alabama | 35801 | Recruiting |
| Ima Clinical Research Phoenix (Alea) /ID# 275737 | Phoenix | Arizona | 85012 | Recruiting |
| Noble Clinical Research /ID# 267952 | Tucson | Arizona | 85704 | Completed |
| Advanced Research Center /ID# 267874 | Anaheim | California | 92805 | Recruiting |
| Axiom Research /ID# 267814 | Colton | California | 92324 | Recruiting |
| Sun Valley Research Center /ID# 267864 | Imperial | California | 92251 | Recruiting |
| Synergy San Diego /ID# 267879 | Lemon Grove | California | 91945 | Recruiting |
| Alliance for Research Alliance for Wellness /ID# 267911 | Long Beach | California | 90807 | Recruiting |
| NRC Research Institute DTLA /ID# 267832 | Los Angeles | California | 90015 | Recruiting |
| Excell Research /ID# 267918 | Oceanside | California | 92056 | Recruiting |
| Inland Psychiatric Medical Group /ID# 268598 | Temecula | California | 92591 | Recruiting |
| Sunwise Clinical Research /ID# 267863 | Walnut Creek | California | 94596 | Recruiting |
| Connecticut Clinical Research - Cromwell /ID# 271241 | Cromwell | Connecticut | 06416 | Recruiting |
| Cns Healthcare - Jacksonville /ID# 268588 | Jacksonville | Florida | 32256 | Recruiting |
| Accel Research Sites Network - St. Pete /ID# 267821 | Largo | Florida | 33777 | Recruiting |
| K2 Medical Research, LLC /ID# 267841 | Maitland | Florida | 32751 | Recruiting |
| GMI Florida - Central Miami Medical Institute /ID# 267839 | Miami | Florida | 33125 | Recruiting |
| Allied Biomedical Res Inst Inc /ID# 267813 | Miami | Florida | 33155 | Recruiting |
| Apg Research /ID# 271707 | Orlando | Florida | 32803 | Recruiting |
| Psych Atlanta /ID# 267878 | Marietta | Georgia | 30060 | Recruiting |
| iResearch Savannah /ID# 267865 | Savannah | Georgia | 31405 | Recruiting |
| University of Chicago Medical Center /ID# 275131 | Chicago | Illinois | 60637 | Recruiting |
| Collective Medical Research /ID# 272015 | Overland Park | Kansas | 66210 | Recruiting |
| CenExel /ID# 267853 | Gaithersburg | Maryland | 20877-1407 | Recruiting |
| Elixia - Springfield /ID# 267815 | Springfield | Massachusetts | 01103 | Recruiting |
| Psychiatric Care And Research Center /ID# 271701 | O'Fallon | Missouri | 63368 | Recruiting |
| Saint Charles Psychiatric Associates /ID# 271202 | Saint Charles | Missouri | 63304 | Recruiting |
| Arch Clinical Trials /ID# 267851 | St Louis | Missouri | 63125 | Recruiting |
| Ima Clinical Research Las Vegas (SMO/Network/Consortium) /ID# 275731 | Las Vegas | Nevada | 89102 | Recruiting |
| Duplicate_Oasis Clinical Research, LLC /ID# 267953 | Las Vegas | Nevada | 89121 | Completed |
| Princeton Medical Institute /ID# 267877 | Princeton | New Jersey | 08540 | Recruiting |
| Bio Behavioral Health /ID# 267919 | Toms River | New Jersey | 08755 | Recruiting |
| Integrative Clinical Trials /ID# 279519 | Brooklyn | New York | 11229 | Recruiting |
| New Hope Clinical Research - Inpatient unit /ID# 267810 | Charlotte | North Carolina | 28211 | Recruiting |
| Quest Therapeutics of Avon /ID# 267829 | Avon Lake | Ohio | 44012-1004 | Recruiting |
| University Of Cincinnati Medical Center /ID# 271704 | Cincinnati | Ohio | 45219 | Recruiting |
| The Ohio State University /ID# 267924 | Columbus | Ohio | 43210 | Recruiting |
| Sooner Clinical Research /ID# 267881 | Oklahoma City | Oklahoma | 73116 | Recruiting |
| Lehigh Center for Clinical Research /ID# 267908 | Allentown | Pennsylvania | 18103 | Recruiting |
| Suburban Research Associates /ID# 267868 | West Chester | Pennsylvania | 19380-4370 | Recruiting |
| Coastal Carolina Research Center, LLC /ID# 267826 | Charleston | South Carolina | 29492 | Recruiting |
| Psychiatric Consultants - Franklin /ID# 275133 | Franklin | Tennessee | 37067 | Recruiting |
| FutureSearch Trials of Dallas /ID# 267870 | Dallas | Texas | 75231 | Recruiting |
| Relaro Medical Trials /ID# 270241 | Dallas | Texas | 75243 | Recruiting |
| Perceptive Pharma Research /ID# 267836 | Richmond | Texas | 77407 | Recruiting |
| Family Psychiatry Of The Woodlands /ID# 275173 | The Woodlands | Texas | 77381 | Recruiting |
| Grayline Research Center /ID# 267811 | Wichita Falls | Texas | 76309 | Recruiting |
| Northwest Clinical Research Center /ID# 267916 | Bellevue | Washington | 98007 | Recruiting |
| Core Clinical Research /ID# 270058 | Everett | Washington | 98201 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 3 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06846320, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jun 16, 2026 · Synced Sep 2, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06846320 live on ClinicalTrials.gov.