A Study to Investigate the Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of RO7497372 in Participants With Diabetic Macular Edema (DME)
Public ClinicalTrials.gov record NCT06847854. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase I, Multipart, Multicenter Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of RO7497372 Following Intravitreal Administration in Participants With Diabetic Macular Edema (Part 1 Non-Randomized, Open-Label, Multiple Ascending Dose; Part 2 Randomized, Double-Masked)
Study identification
- NCT ID
- NCT06847854
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 1
- Lead sponsor
- Genentech, Inc.
- Industry
- Enrollment
- 151 participants
Conditions and interventions
Conditions
Interventions
- RO7497372 Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Not listed
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 7, 2022
- Primary completion
- Nov 15, 2026
- Completion
- Jan 11, 2027
- Last update posted
- Apr 19, 2026
2022 – 2027
United States locations
- U.S. sites
- 37
- U.S. states
- 20
- U.S. cities
- 37
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Barnet Dulaney Perkins Eye Center | Mesa | Arizona | 85206 | — |
| Retinal Consultants of AZ, Ltd | Peoria | Arizona | 85381 | — |
| Associated Retina Consultants | Phoenix | Arizona | 85020 | — |
| Arkansas Retina Research | Little Rock | Arkansas | 72205 | — |
| Global Research Management | Glendale | California | 91204 | — |
| Retinal Consultants Medical Group | Modesto | California | 95356 | — |
| Bay Area Retina Associates | Walnut Creek | California | 94598 | — |
| Florida Eye Associates | Melbourne | Florida | 32901 | — |
| Medeye Associates | Miami | Florida | 33143 | — |
| East Florida Eye Institute | Stuart | Florida | 34994 | — |
| Retina Specialists of Tampa | Wesley Chapel | Florida | 33544 | — |
| Center for Retina and Macula Disease | Winter Haven | Florida | 33880 | — |
| Cumberland Valley Retina PC | Hagerstown | Maryland | 21740 | — |
| Retina Associates of Michigan | Grand Blanc | Michigan | 48439-8301 | — |
| Foundation for Vision Research | Grand Rapids | Michigan | 49546 | — |
| Retina Consultants Minnesota | Saint Louis Park | Minnesota | 55416 | — |
| Mississippi Retina Associates | Madison | Mississippi | 39202 | — |
| The Retina Institute | St Louis | Missouri | 63128 | — |
| Sierra Eye Associates | Reno | Nevada | 89502 | — |
| Ross Eye Institute | Buffalo | New York | 14209-2102 | — |
| Retina Associates of NY | New York | New York | 10075 | — |
| Cleveland Clinic | Cleveland | Ohio | 44106 | — |
| Verum Research LLC | Eugene | Oregon | 97401 | — |
| EyeHealth Northwest | Portland | Oregon | 97225 | — |
| Erie Retinal Surgery | Erie | Pennsylvania | 16507 | — |
| Mid Atlantic Retina | Philadelphia | Pennsylvania | 19107 | — |
| Carolina Eyecare Physicians | Mt. Pleasant | South Carolina | 29464 | — |
| Charles Retina Institute | Germantown | Tennessee | 38138 | — |
| Austin Clinical Research LLC | Austin | Texas | 78750 | — |
| Brown Retina Institute | Schertz | Texas | 78154 | — |
| Retina Consultants of Texas | The Woodlands | Texas | 77384 | — |
| Salt Lake Retina | West Jordan | Utah | 84088 | — |
| Retina Group of Washington | Fairfax | Virginia | 20815 | — |
| Emerson Clinical Research Institute | Falls Church | Virginia | 78503 | — |
| Piedmont Eye Center | Lynchburg | Virginia | 24502 | — |
| Wagner Kapoor Institute | Norfolk | Virginia | 23502 | — |
| Spokane Eye Clinical Research | Spokane | Washington | 99204-2509 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 1 non-U.S. site.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06847854, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 19, 2026 · Synced Apr 22, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06847854 live on ClinicalTrials.gov.