Efficacy and Safety of 186 mcg of OPN-375 Nasal Spray Twice a Day (BID) in Adolescents With Chronic Rhinosinusitis Without Nasal Polyps
Public ClinicalTrials.gov record NCT06850805. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A 12-Week Randomized, Double-Blind, Placebo-Controlled, Multicenter Study Evaluating the Efficacy and Safety of Intranasal Administration of 186 mcg of OPN-375 Twice a Day (BID) in Adolescent Subjects With Chronic Rhinosinusitis Without Nasal Polyps
Study identification
- NCT ID
- NCT06850805
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Optinose US Inc.
- Industry
- Enrollment
- 84 participants
Conditions and interventions
Conditions
Interventions
- OPN-375 Drug
- Placebo Drug
Drug
Eligibility (public fields only)
- Age range
- 12 Years to 17 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 27, 2025
- Primary completion
- Mar 30, 2028
- Completion
- Oct 30, 2028
- Last update posted
- Mar 22, 2026
2025 – 2028
United States locations
- U.S. sites
- 21
- U.S. states
- 14
- U.S. cities
- 20
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| San Tan Allergy & Asthma | Gilbert | Arizona | 85214 | Withdrawn |
| Children's Hospital of Orange County | Orange | California | 92868 | Recruiting |
| DaVinci Research, LLC | Sacramento | California | 95661 | Recruiting |
| Breathe Clear Institute | Torrance | California | 90503 | Recruiting |
| Children's Hospital Colorado | Aurora | Colorado | 80045 | Recruiting |
| Colorado ENT & Allergy | Colorado Springs | Colorado | 80909 | Recruiting |
| Children's Healthcare of Atlanta | Atlanta | Georgia | 30329 | Not yet recruiting |
| Southern Illinois University School of Medicine | Springfield | Illinois | 62702 | Recruiting |
| Kentuckiana ENT | Louisville | Kentucky | 40205 | Recruiting |
| Centers for Advanced ENT Care | Towson | Maryland | 21204 | Recruiting |
| University of Missouri Medical Center | Columbia | Missouri | 65212 | Not yet recruiting |
| University of Rochester Medical Center | Rochester | New York | 14642 | Recruiting |
| Allergy, Asthma and Clinical Research Center | Oklahoma City | Oklahoma | 73120 | Recruiting |
| Vital Prospects Clinical Research Institute | Tulsa | Oklahoma | 74136 | Recruiting |
| Charleston ENT & Allergy | North Charleston | South Carolina | 29414 | Recruiting |
| Carolina ENT Clinic/CENTRI Inc. | Orangeburg | South Carolina | 29118 | Recruiting |
| Orion Clinical Research | Austin | Texas | 78759 | Recruiting |
| STAAMP Research | San Antonio | Texas | 78229 | Recruiting |
| Alamo ENT Associates | San Antonio | Texas | 78258 | Recruiting |
| University of Utah | Salt Lake City | Utah | 84112 | Not yet recruiting |
| EVMS at Old Dominion University | Norfolk | Virginia | 23507 | Not yet recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06850805, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 22, 2026 · Synced May 17, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06850805 live on ClinicalTrials.gov.