ClinicalTrials.gov record
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of RO7446603 Administered Alone or in Combination With Aflibercept or Faricimab in Participants With Diabetic Macular Edema
ClinicalTrials.gov ID: NCT06850922
Public ClinicalTrials.gov record NCT06850922. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced May 4, 2026, 4:16 PM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase I/II Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of RO7446603 Administered Alone or in Combination With Aflibercept or Faricimab in Patients With Diabetic Macular Edema
Study identification
- NCT ID
- NCT06850922
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 1, Phase 2
- Lead sponsor
- Genentech, Inc.
- Industry
- Enrollment
- 546 participants
Conditions and interventions
Conditions
Interventions
- Aflibercept Drug
- Faricimab Drug
- RO7446603 Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 21, 2022
- Primary completion
- Apr 29, 2027
- Completion
- Apr 29, 2027
- Last update posted
- Apr 26, 2026
2022 – 2027
United States locations
- U.S. sites
- 69
- U.S. states
- 24
- U.S. cities
- 62
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Arizona Retina and Vitreous Consultants | Phoenix | Arizona | 85020-5917 | — |
| Associated Retinal Consultants PC | Phoenix | Arizona | 85020 | — |
| Retinal Research Institute, LLC | Phoenix | Arizona | 85053 | — |
| Retinal Diagnostic Center | Campbell | California | 95008 | — |
| Retina Consultants of Orange County | Fullerton | California | 92835 | — |
| Retinal Consultants Medical Group | Modesto | California | 95356-9412 | — |
| Northern California Retina-Vitreous Associates | Mountain View | California | 94040 | — |
| Retinal Consultants Medical Group | Sacramento | California | 95825 | — |
| University of California San Francisco | San Francisco | California | 94158 | — |
| Macula Retina Vitreous Research Institute | Torrance | California | 90503-3270 | — |
| Bay Area Retina Associates;Study Department | Walnut Creek | California | 94598 | — |
| University of Colorado - Eye Center - PPDS | Aurora | Colorado | 80045-2517 | — |
| Retina Consultants of Southern Colorado PC | Colorado Springs | Colorado | 80909 | — |
| Retina Specialists of Colorado | Denver | Colorado | 80222 | — |
| Advanced Vision Research Institute | Longmont | Colorado | 80503-6499 | — |
| Retina Group of New England | Waterford | Connecticut | 06385-1215 | — |
| National Ophthalmic Research Institute | Fort Myers | Florida | 33912 | — |
| Florida Retina Institute | Jacksonville | Florida | 32216-6347 | — |
| Retina Associates of Florida;Retina Associates of Florida | Tampa | Florida | 33609 | — |
| Southeast Retina Center | Augusta | Georgia | 30909-6440 | — |
| Georgia Retina PC | Marietta | Georgia | 30060 | — |
| Retina Consultants of Hawaii | ‘Aiea | Hawaii | 96701 | — |
| Illinois Eye and Ear Infirmary | Chicago | Illinois | 60612 | — |
| University Retina and Macula Associates, PC | Oak Forest | Illinois | 60452 | — |
| Raj K. Maturi, MD PC | Indianapolis | Indiana | 46290 | — |
| The Retina Care Center | Baltimore | Maryland | 21209 | — |
| Johns Hopkins Hospital | Baltimore | Maryland | 21287 | — |
| Retina Group of Washington | Chevy Chase | Maryland | 20815 | — |
| Cumberland Valley Retina Consultants | Hagerstown | Maryland | 21740 | — |
| Chesapeake Retina Centers - Waldorf | Waldorf | Maryland | 20602 | — |
| Associated Retinal Consultants - Royal Oak | Royal Oak | Michigan | 48073 | — |
| Retina Consultants Minnesota | Saint Louis Park | Minnesota | 55416 | — |
| Long Island Vitreoretinal Consultants;Opthalmology | Hauppauge | New York | 11788 | — |
| Retina Vitreous Surgeons of CNY PC | Liverpool | New York | 13088 | — |
| Opthalmic Consultants of LI | Lynbrook | New York | 11563 | — |
| Western Carolina Retinal Associate PA | Asheville | North Carolina | 28803 | — |
| North Carolina Retina Associates | Cary | North Carolina | 27511 | — |
| Duke University Medical Center | Durham | North Carolina | 27705 | — |
| Graystone Eye | Hickory | North Carolina | 28602 | — |
| North Carolina (NC) Retina Associates - Wake Forest Office | Wake Forest | North Carolina | 27587-3803 | — |
| Piedmont Retina Specialists | Winston-Salem | North Carolina | 27103-6970 | — |
| Cincinnati Eye Institute | Blue Ash | Ohio | 45242-5537 | — |
| University Hospitals Cleveland Medical Center | Cleveland | Ohio | 44016 | — |
| Ohio State Eye and Ear Institute | Columbus | Ohio | 43212 | — |
| Tulsa Retina Consultants | Tulsa | Oklahoma | 74114 | — |
| Cascade Medical Research Institute LLC | Springfield | Oregon | 97477 | — |
| Erie Retina Research | Erie | Pennsylvania | 16505 | — |
| Wills Eye Hospital | Philadelphia | Pennsylvania | 19107-5109 | — |
| Sewickely Eye Group | Sewickley | Pennsylvania | 15143 | — |
| Palmetto Retina Center | West Columbia | South Carolina | 29169-2429 | — |
| Charles Retina Institute | Germantown | Tennessee | 38138 | — |
| Retina Research Institute of Texas | Abilene | Texas | 79606 | — |
| Texas Retina Associates | Arlington | Texas | 76012 | — |
| Austin Retina Associates | Austin | Texas | 78705 | — |
| Austin Clinical Research LLC | Austin | Texas | 78750 | — |
| Retina & Vitreous of Texas | Bellaire | Texas | 77401 | — |
| Texas Retina Associates | Dallas | Texas | 75231 | — |
| Valley Retina Institute P.A. | McAllen | Texas | 78550-9207 | — |
| Medical Center Ophthalmology Associates | San Antonio | Texas | 78240 | — |
| Retina Consultants of Texas - San Antonio | San Antonio | Texas | 78240 | — |
| Brown Retina Institute | San Antonio | Texas | 78251-4551 | — |
| Retina Consultants of Texas | The Woodlands | Texas | 77384 | — |
| Strategic Clinical Research Group, LLC | Willow Park | Texas | 76087 | — |
| Retina Associates of Utah, PLLC;Clinical Research | Salt Lake City | Utah | 84107 | — |
| Piedmont Eye Center | Lynchburg | Virginia | 24502-4271 | — |
| Wagner Kapoor Institute | Norfolk | Virginia | 23502 | — |
| Virginia Eye Institute - Richmond - 7301 Forest Ave | Richmond | Virginia | 23230 | — |
| Retina Institute of Virginia | Richmond | Virginia | 23235-1962 | — |
| Spokane Eye Clinical Research | Spokane | Washington | 99204 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 7 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06850922, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 26, 2026 · Synced May 4, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06850922 live on ClinicalTrials.gov.