The Multicenter Stress Cardiac Magnetic Resonance Quantitative Perfusion Imaging in the United States Study
Public ClinicalTrials.gov record NCT06854458. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
The Multicenter Stress Cardiac Magnetic Resonance Quantitative Perfusion Imaging in the United States (SPINS2) Study
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This research aims to investigate whether symptoms of chest pain or shortness of breath among the study population are arising due to a heart problem, particularly any reduction of blood flow to the heart muscle from blockages in the coronary blood vessels or inflammation of the heart using cardiac magnetic resonance imaging that measures the amount of blood flow during a stress state meant to simulate vigorous exercise. At present, doctors use standard magnetic resonance imaging pictures of blood flow patterns to treat heart disease. The investigators want to study if detailed blood flow measurements, in addition to the standard blood flow pattern, could diagnose heart disease more accurately and allow more doctors to understand the severity of heart disease. Early research has demonstrated that detailed blood flow measurements may be more accurate in diagnosing heart disease in some patients, but doctors need more information to know how to use these measurements.
Study identification
- NCT ID
- NCT06854458
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Not applicable
- Enrollment
- 1,000 participants
Conditions and interventions
Interventions
- Quantitative Myocardial Blood Flow Evaluation Diagnostic Test
- Qualitative Myocardial Blood Flow Evaluation Diagnostic Test
- Gadavist Drug
- Vasodilator Drug
- Blood draw for the laboratory assessment Diagnostic Test
Diagnostic Test · Drug
Eligibility (public fields only)
- Age range
- 35 Years to 85 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 26, 2025
- Primary completion
- Dec 31, 2028
- Completion
- Feb 28, 2029
- Last update posted
- Aug 31, 2026
2025 – 2029
United States locations
- U.S. sites
- 13
- U.S. states
- 10
- U.S. cities
- 12
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of California San Francisco | San Francisco | California | 94107 | Recruiting |
| UofL Health - Heart Hospital | Louisville | Kentucky | 40202 | Recruiting |
| Brigham and Women's Hospital | Boston | Massachusetts | 02115 | Recruiting |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215 | Recruiting |
| St. Francis Hospital and Heart Center | Roslyn | New York | 11576 | Recruiting |
| Atrium Health - Sanger Heart & Vascular Institute | Charlotte | North Carolina | 28204 | Recruiting |
| Cleveland Clinic | Cleveland | Ohio | 44195 | Recruiting |
| The Ohio State University | Columbus | Ohio | 43210 | Recruiting |
| Vanderbilt University Medical Center | Nashville | Tennessee | 37203 | Recruiting |
| Houston Methodist Hospital | Houston | Texas | 77030 | Recruiting |
| University of Utah | Salt Lake City | Utah | 84108 | Recruiting |
| University of Virginia | Charlottesville | Virginia | 22908 | Recruiting |
| Virginia Commonwealth University | Richmond | Virginia | 23298 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06854458, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 31, 2026 · Synced Sep 9, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06854458 live on ClinicalTrials.gov.