A Platform Protocol to Investigate Post-Transplant Cyclophosphamide-Based Graft-Versus-Host Disease Prophylaxis in Patients With Hematologic Malignancies Undergoing Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation

ClinicalTrials.gov ID: NCT06859424

Public ClinicalTrials.gov record NCT06859424. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 8, 2026, 7:55 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Study identification

NCT ID: NCT06859424
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 2
Lead sponsor: Center for International Blood and Marrow Transplant Research; Network
Enrollment: 358 participants

Conditions and interventions

Conditions

Interventions

Conditioning Regimen A Drug
Conditioning Regimen B Drug
Conditioning Regimen C Drug
Conditioning Regimen D Drug
Conditioning Regimen E Drug
Hematopoietic Cell Transplantation Procedure
PTCy (25 mg/kg D3, D4) Drug
PTCy (50 mg/kg D3, D4) Drug
Permitted Concomitant Therapy Other
Post-transplant Abatacept Drug
Post-transplant Mycophenolate mofetil Drug
Post-transplant Ruxolitinib Drug
Post-transplant Tacrolimus Drug
Prohibited Concomitant Therapy Other
Study treatment compliance Other
Supportive Care: Blood Products Procedure
Supportive Care: Growth Factors Drug
Supportive Care: Infection Prophylaxis Other
Supportive Care: Intravenous immune globulin (IVIG) Other
Supportive Care: Lipid elevations Other
Supportive Care: Monitoring and management of CRS Other
Supportive Care: Prophylaxis against infections Drug
Supportive Care: Prophylaxis against infections Other
Supportive Care: Seizure prophylaxis Drug

Drug · Procedure · Other

Eligibility (public fields only)

Age range: 18 Years to 66 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Jul 24, 2025
Primary completion: May 31, 2028
Completion: May 31, 2028
Last update posted: Mar 16, 2026

2025 – 2028

United States locations

U.S. sites: 13
U.S. states: 12
U.S. cities: 13

Facility	City	State	ZIP	Site status
University of Alabama Birmingham	Birmingham	Alabama	35294	Recruiting
City of Hope	Duarte	California	91010	Recruiting
Stanford	Palo Alto	California	94304	Recruiting
University of Miami	Miami	Florida	33136	Recruiting
University of Kansas Medical Center	Westwood	Kansas	66205	Recruiting
Dana-Farber Cancer Institute	Boston	Massachusetts	02446	Recruiting
Karmanos Cancer Institute	Detroit	Michigan	48201	Recruiting
Memorial Sloan Kettering	New York	New York	10065	Recruiting
University of North Carolina	Chapel Hill	North Carolina	27514	Recruiting
Oregon Health & Science University	Portland	Oregon	97239	Recruiting
MD Anderson	Houston	Texas	77030	Recruiting
University of Virginia	Charlottesville	Virginia	22903	Recruiting
Fred Hutchinson Cancer Center	Seattle	Washington	98109	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT06859424, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Mar 16, 2026 · Synced May 8, 2026

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The complete protocol, eligibility criteria, and contact information for NCT06859424 live on ClinicalTrials.gov.

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