Study of Once-Daily Oral RGT001-075 Compared With Placebo in Adults With Obesity or Are Overweight With Weight-Related Health Conditions
Public ClinicalTrials.gov record NCT06867718. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2 Study of Once-Daily RGT001-075 Compared With Placebo in Participants Who Have Obesity or Are Overweight With Weight-Related Comorbidities (COMO-1)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a phase 2, 36-week randomized, double-blind, placebo-controlled, parallel arm study that will evaluate the safety, tolerability, weight loss efficacy, pharmacodynamic effects, and pharmacokinetics of RGT001-075 in adults who are obese (BMI ≥30 kg/m²) or who are overweight (BMI ≥27 kg/m²) with at least one weight-related comorbidity. RGT001-075 or matching placebo will be administered once daily.
Study identification
- NCT ID
- NCT06867718
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 267 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 75 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 24, 2025 (Actual)
- Primary completion
- Nov 6, 2025 (Actual)
- Completion
- Nov 6, 2025 (Actual)
- Last update posted
- May 28, 2026
2025
United States locations
- U.S. sites
- 35
- U.S. states
- 21
- U.S. cities
- 34
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Alliance for Multispecialty Research, LLC | Mobile | Alabama | 36608 | — |
| Synexus Clinical Research | Phoenix | Arizona | 85020 | — |
| Velocity Clinical Research | Huntington Park | California | 90255 | — |
| Angels Clinical Research | Doral | Florida | 33122 | — |
| Optimal Research | Melbourne | Florida | 32934 | — |
| Angels Clinical Research | Miami | Florida | 33126 | — |
| Palm Springs Community Health Center | Miami Lakes | Florida | 33014 | — |
| Synexus Clinical Research | The Villages | Florida | 32162 | — |
| Javara-Privia Medical Group, Georgia LLC | Savannah | Georgia | 31406 | — |
| Javara-Privia Medical Group, Georgia, LLC | Thomasville | Georgia | 31792 | — |
| Synexus Clinical Research | Evansville | Indiana | 47714 | — |
| Velocity Clinical Research | Valparaiso | Indiana | 46383 | — |
| Alliance for Multispecialty Research, LLC | Lexington | Kentucky | 40509 | — |
| Velocity Clinical Research | Baton Rouge | Louisiana | 70809 | — |
| Velocity Clinical Research | Rockville | Maryland | 20854 | — |
| Mankato Clinic-East Main Street-Javara | Mankato | Minnesota | 56001 | — |
| Synexus Clinical Research | Richfield | Minnesota | 55423 | — |
| Synexus Clinical Research | Creve Coeur | Missouri | 63141 | — |
| Velocity Clinical Research | Omaha | Nebraska | 68134 | — |
| Premier Health Research-Sparta-Objective Health | Sparta | New Jersey | 07871 | — |
| Velocity Clinical Research | Vestal | New York | 13850 | — |
| Javara-Tryon Medical Partners, PLLC | Charlotte | North Carolina | 28287 | — |
| Velocity Clinical Research | Durham | North Carolina | 27701 | — |
| Velocity Clinical Research | Cincinnati | Ohio | 45246 | — |
| Velocity Clinical Research | Cleveland | Ohio | 44122 | — |
| Alliance for Multispecialty Research, LLC | Norman | Oklahoma | 73069 | — |
| Velocity Clinical Research | East Greenwich | Rhode Island | 02818 | — |
| Velocity Clinical Research | Dallas | Texas | 75230 | — |
| Synexus Clinical Research | Dallas | Texas | 75234 | — |
| Synexus Clinical Research | San Antonio | Texas | 78229 | — |
| Javara-Privia Medical Group Gulf Coast PLLC | The Woodlands | Texas | 77384 | — |
| Velocity Clinical Research | Waco | Texas | 76710 | — |
| Synexus Clinical Research | Salt Lake City | Utah | 84106 | — |
| Velocity Clinical Research | West Jordan | Utah | 84088 | — |
| Velocity Clinical Research | Seattle | Washington | 98105 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06867718, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 28, 2026 · Synced Oct 30, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06867718 live on ClinicalTrials.gov.