A Double-blind Study Evaluating the Efficacy, Safety, and Tolerability of Zorevunersen in Patients With Dravet Syndrome

ClinicalTrials.gov ID: NCT06872125

Public ClinicalTrials.gov record NCT06872125. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Sep 11, 2026, 8:02 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

EMPEROR: A Multicenter, Randomized, Double-blind, Sham-controlled, Parallel Group, Phase 3 Study Evaluating the Efficacy, Safety, and Tolerability of Zorevunersen (STK-001) in Patients With Dravet Syndrome

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

The purpose of the study is to evaluate the efficacy, safety, and tolerability of zorevunersen in Patients with Dravet syndrome.

Study identification

NCT ID: NCT06872125
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: Stoke Therapeutics, Inc; Industry
Enrollment: 170 participants

Conditions and interventions

Conditions

Dravet Syndrome

Interventions

zorevunersen Drug
Sham Comparator Other

Drug · Other

Eligibility (public fields only)

Age range: 2 Years to 17 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Jun 3, 2025
Primary completion: Feb 28, 2027
Completion: Sep 30, 2028
Last update posted: Aug 23, 2026

2025 – 2028

United States locations

U.S. sites: 28
U.S. states: 18
U.S. cities: 26

Facility	City	State	ZIP	Site status
Phoenix Children's Hospital	Phoenix	Arizona	85016	Active, not recruiting
Arkansas Children's Hospital	Little Rock	Arkansas	72202	Active, not recruiting
Cedars Sinai Medical Center	Los Angeles	California	90048	Active, not recruiting
Children's Hospital of Orange County	Orange	California	92868	Active, not recruiting
USCF Medical Center	San Francisco	California	94158	Active, not recruiting
Children's Hospital Colorado	Aurora	Colorado	80045	Active, not recruiting
Children's National Medical Center	Washington D.C.	District of Columbia	20010	Active, not recruiting
Nemours Children's Health	Jacksonville	Florida	32207	Active, not recruiting
Nicklaus Children's Hospital	Miami	Florida	33155	Active, not recruiting
Advent Health Neuroscience Research Institute	Orlando	Florida	32804	Active, not recruiting
Ann & Robert H. Lurie Children's Hospital of Chicago	Chicago	Illinois	60611	Active, not recruiting
Massachusetts General Hospital	Boston	Massachusetts	02114	Active, not recruiting
Boston Children's Hospital	Boston	Massachusetts	02115	Active, not recruiting
CS Mott Children's Hospital	Ann Arbor	Michigan	48109	Active, not recruiting
Mayo Clinic	Rochester	Minnesota	55905	Active, not recruiting
NYU Langone Health	New York	New York	10016	Active, not recruiting
Weill Cornell Medicine	New York	New York	10021	Active, not recruiting
University of Rochester Medical Center	Rochester	New York	14642	Active, not recruiting
University of North Carolina at Chapel Hill	Chapel Hill	North Carolina	27514	Active, not recruiting
Duke University Health System	Durham	North Carolina	27705	Active, not recruiting
Cleveland Clinic	Cleveland	Ohio	44195	Active, not recruiting
Nationwide Children's Hospital	Columbus	Ohio	43205	Active, not recruiting
Oregon Health & Science University (OHSU)	Portland	Oregon	97239	Active, not recruiting
LeBonheur Children's Hospital	Memphis	Tennessee	38103	Active, not recruiting
Cook Children's Medical Center	Fort Worth	Texas	76104	Active, not recruiting
Texas Children's Hospital	Houston	Texas	77030	Active, not recruiting
University of Utah Primary Children's Hospital	Salt Lake City	Utah	84113	Active, not recruiting
UVA Health	Charlottesville	Virginia	22903	Active, not recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 33 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT06872125, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Aug 23, 2026 · Synced Sep 11, 2026

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The complete protocol, eligibility criteria, and contact information for NCT06872125 live on ClinicalTrials.gov.

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