ClinicalTrials.gov record
A Study of Adagrasib Plus Pembrolizumab Plus Chemotherapy vs. Placebo Plus Pembrolizumab Plus Chemotherapy in Participants With Previously Untreated Non-squamous Non-small Cell Lung Cancer With KRAS G12C Mutation (KRYSTAL-4)
ClinicalTrials.gov ID: NCT06875310
Public ClinicalTrials.gov record NCT06875310. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Double-Blind, Phase 3 Trial of Adagrasib Plus Pembrolizumab Plus Chemotherapy vs. Placebo Plus Pembrolizumab Plus Chemotherapy in Participants With Previously Untreated, Locally Advanced or Metastatic Non-squamous Non-small Cell Lung Cancer With KRAS G12C Mutation (KRYSTAL-4)
Study identification
- NCT ID
- NCT06875310
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 630 participants
Conditions and interventions
Conditions
Interventions
- Adagrasib Drug
- Carboplatin Drug
- Cisplatin Drug
- Pembrolizumab Drug
- Pemetrexed Drug
- Placebo Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Apr 23, 2025
- Primary completion
- Sep 6, 2029
- Completion
- Apr 29, 2032
- Last update posted
- May 12, 2026
2025 – 2032
United States locations
- U.S. sites
- 53
- U.S. states
- 21
- U.S. cities
- 50
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Local Institution - 0347 | Birmingham | Alabama | 35294 | Not yet recruiting |
| Local Institution - 0686 | Springdale | Arkansas | 72762 | Not yet recruiting |
| Local Institution - 0581 | Fullerton | California | 92835 | Not yet recruiting |
| Local Institution - 0682 | Loma Linda | California | 92354 | Not yet recruiting |
| Helios Clinical Research | Long Beach | California | 90805 | Recruiting |
| Local Institution - 0442 | Denver | Colorado | 80206 | Not yet recruiting |
| Local Institution - 0701 | Newark | Delaware | 19713 | Not yet recruiting |
| Local Institution - 0694 | Clearwater | Florida | 33756 | Not yet recruiting |
| Local Institution - 0052 | Jacksonville | Florida | 32256 | Not yet recruiting |
| Local Institution - 0696 | Miami | Florida | 33176 | Not yet recruiting |
| Local Institution - 0680 | Ocala | Florida | 34474 | Not yet recruiting |
| Local Institution - 0679 | Orange City | Florida | 32763 | Not yet recruiting |
| Local Institution - 0621 | Palm Bay | Florida | 32901 | Not yet recruiting |
| Florida Clinical Trials Group. | Plantation | Florida | 33322 | Recruiting |
| Local Institution - 0695 | St. Petersburg | Florida | 33705 | Not yet recruiting |
| Florida Clinical Trials Group. | Tamarac | Florida | 33321 | Recruiting |
| Local Institution - 0647 | Tampa | Florida | 33612 | Not yet recruiting |
| Local Institution - 0699 | Tampa | Florida | 33612 | Not yet recruiting |
| Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital | Marietta | Georgia | 30060 | Recruiting |
| Local Institution - 0665 | Arlington Heights | Illinois | 60005 | Not yet recruiting |
| Local Institution - 0676 | Chicago | Illinois | 60612 | Not yet recruiting |
| Local Institution - 0683 | Springfield | Illinois | 62703 | Not yet recruiting |
| Local Institution - 0454 | Dyer | Indiana | 46311 | Not yet recruiting |
| Local Institution - 0684 | Fort Wayne | Indiana | 46845 | Not yet recruiting |
| Local Institution - 0423 | Munster | Indiana | 46321 | Withdrawn |
| Local Institution - 0366 | Edgewood | Kentucky | 41017 | Not yet recruiting |
| Local Institution - 0566 | Louisville | Kentucky | 40202 | Not yet recruiting |
| Local Institution - 0693 | Owensboro | Kentucky | 42303 | Not yet recruiting |
| Local Institution - 0698 | Paducah | Kentucky | 42003 | Not yet recruiting |
| Local Institution - 0644 | Shreveport | Louisiana | 71103 | Not yet recruiting |
| Local Institution - 0691 | Baltimore | Maryland | 21202 | Not yet recruiting |
| Local Institution - 0385 | Columbia | Maryland | 21044 | Not yet recruiting |
| Local Institution - 0019 | Boston | Massachusetts | 02215 | Not yet recruiting |
| Local Institution - 0293 | Detroit | Michigan | 48201 | Not yet recruiting |
| Local Institution - 0685 | Fenton | Missouri | 63026 | Not yet recruiting |
| Local Institution - 0678 | Cooperstown | New York | 13326 | Not yet recruiting |
| Local Institution - 0689 | Rochester | New York | 14642 | Not yet recruiting |
| Ellis Hospital | Schenectady | New York | 12308 | Recruiting |
| Local Institution - 0618 | White Plains | New York | 10601 | Not yet recruiting |
| Local Institution - 0624 | Asheville | North Carolina | 28806 | Not yet recruiting |
| Local Institution - 0672 | Salisbury | North Carolina | 28144 | Not yet recruiting |
| Local Institution - 0688 | Easton | Pennsylvania | 18045 | Not yet recruiting |
| Local Institution - 0376 | Hershey | Pennsylvania | 17033 | Not yet recruiting |
| WellSpan Oncology Research | York | Pennsylvania | 17403 | Recruiting |
| Local Institution - 0681 | Greenville | South Carolina | 29605 | Not yet recruiting |
| Local Institution - 0658 | Greenville | South Carolina | 29607 | Not yet recruiting |
| Local Institution - 0020 | Nashville | Tennessee | 37203 | Not yet recruiting |
| Local Institution - 0697 | Nashville | Tennessee | 37212 | Not yet recruiting |
| Local Institution - 0034 | Dallas | Texas | 75246 | Not yet recruiting |
| Local Institution - 0692 | Galveston | Texas | 77555 | Not yet recruiting |
| Local Institution - 0652 | Laredo | Texas | 78041 | Not yet recruiting |
| Local Institution - 0622 | San Antonio | Texas | 78217 | Not yet recruiting |
| Local Institution - 0700 | Tyler | Texas | 75702 | Not yet recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 297 non-U.S. sites.
Recently updated Carcinoma, Non-Small-Cell Lung trials
Other public records listing Carcinoma, Non-Small-Cell Lung. Sorted by last update posted; newest first. Not a recommendation.
- NCT07586202: A Study of Neoadjuvant Amivantamab With Either Lazertinib or Chemotherapy in Participants With Resectable EGFR-Mutated NSCLC Recruiting
- NCT07339176: Intratumoral N17350 in Advanced Solid Tumors Recruiting
- NCT03381274: Oleclumab (MEDI9447) Epidermal Growth Factor Receptor Mutant (EGFRm) Non-small Cell Lung Cancer (NSCLC) Novel Combination Study Active, not recruiting
- NCT06116786: A Study of JNJ-86974680 in Participants With Advanced Non-small Cell Lung Cancer Recruiting
- NCT06566443: Honokiol in Early-Stage Resectable Non-Small Cell Lung Cancer Recruiting
- NCT07222566: Symbiotic-Lung-01 : A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer Recruiting
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06875310, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 12, 2026 · Synced May 19, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06875310 live on ClinicalTrials.gov.