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Recruiting Phase 3 Interventional

A Study of Adagrasib Plus Pembrolizumab Plus Chemotherapy vs. Placebo Plus Pembrolizumab Plus Chemotherapy in Participants With Previously Untreated Non-squamous Non-small Cell Lung Cancer With KRAS G12C Mutation (KRYSTAL-4)

ClinicalTrials.gov ID: NCT06875310

Public ClinicalTrials.gov record NCT06875310. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Oct 16, 2026, 10:06 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Randomized, Double-Blind, Phase 3 Trial of Adagrasib Plus Pembrolizumab Plus Chemotherapy vs. Placebo Plus Pembrolizumab Plus Chemotherapy in Participants With Previously Untreated, Locally Advanced or Metastatic Non-squamous Non-small Cell Lung Cancer With KRAS G12C Mutation (KRYSTAL-4)

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

This is a trial to evaluate the efficacy, safety, and tolerability of adagrasib plus pembrolizumab plus platinum-doublet chemotherapy versus placebo plus pembrolizumab plus platinum-doublet chemotherapy in participants with previously untreated, locally advanced or metastatic NSCLC with KRAS G12C mutation

Study identification

NCT ID
NCT06875310
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 3
Lead sponsor
Mirati Therapeutics Inc.
Industry
Enrollment
630 participants

Conditions and interventions

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Apr 24, 2025 (Actual)
Primary completion
Sep 7, 2029 (Estimated)
Completion
Apr 30, 2032 (Estimated)
Last update posted
Oct 13, 2026

2025 – 2032

United States locations

U.S. sites
52
U.S. states
22
U.S. cities
49
Facility City State ZIP Site status
University of Alabama at Birmingham Birmingham Alabama 35294 Recruiting
Highlands Oncology Group - Springdale Springdale Arkansas 72762 Recruiting
Providence Medical Foundation Fullerton California 92835 Recruiting
Local Institution - 0682 Loma Linda California 92354 Not yet recruiting
Helios Clinical Research Long Beach California 90805 Recruiting
National Jewish Health Medical Center Denver Colorado 80206 Recruiting
Medical Oncology Hematology Consultants, PA Newark Delaware 19713 Recruiting
Morton Plant Hospital - BayCare Health System Clearwater Florida 33756 Recruiting
Cancer Specialists of North Florida Jacksonville Florida 32256 Recruiting
Local Institution - 0696 Miami Florida 33176 Not yet recruiting
Ocala Oncology Center PL DBA Florida Cancer Affiliates - Ocala Ocala Florida 34474 Recruiting
Mid Florida Hematology and Oncology Center Orange City Florida 32763 Recruiting
Cancer Care Centers of Brevard, Inc. Palm Bay Florida 32901 Recruiting
Florida Clinical Trials Group. Plantation Florida 33322 Recruiting
St. Anthony's Hospital St. Petersburg Florida 33705 Recruiting
Florida Clinical Trials Group. Tamarac Florida 33321 Recruiting
H. Lee Moffitt Cancer Center & Research Institute Tampa Florida 33612 Recruiting
Local Institution - 0647 Tampa Florida 33612 Not yet recruiting
Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital Marietta Georgia 30060 Recruiting
Illinois Cancer Specialists Arlington Heights Illinois 60005 Recruiting
University of Illinois at Chicago Chicago Illinois 60612 Recruiting
Springfield Clinic Main Campus Springfield Illinois 62703 Recruiting
Northwest Cancer Centers, P.C. Dyer Indiana 46311 Recruiting
Parkview Research Center at Parkview Regional Medical Center Fort Wayne Indiana 46845 Recruiting
Local Institution - 0423 Munster Indiana 46321 Withdrawn
Mercy Medical Center Cedar Rapids Iowa 52403 Recruiting
Saint Elizabeth Medical Center Edgewood Edgewood Kentucky 41017 Recruiting
The University of Louisville, James Graham Brown Cancer Center Louisville Kentucky 40202 Recruiting
Owensboro Medical Health System Owensboro Kentucky 42303 Recruiting
Mercy Health-Paducah Medical Oncology and Hematology Paducah Kentucky 42003 Recruiting
Louisiana State University Health Sciences Shreveport Shreveport Louisiana 71103 Recruiting
Velocity Clinical Research, Annapolis Annapolis Maryland 21401 Recruiting
Maryland Oncology Hematology - Columbia Columbia Maryland 21044 Recruiting
Dana-Farber Cancer Institute Boston Massachusetts 02215 Recruiting
Karmanos Cancer Institute Detroit Michigan 48201 Recruiting
SSM Health Cancer Care - Fenton Fenton Missouri 63026 Recruiting
Local Institution - 0678 Cooperstown New York 13326 Not yet recruiting
Ellis Hospital Schenectady New York 12308 Recruiting
White Plains Hospital White Plains New York 10601 Recruiting
Local Institution - 0624 Asheville North Carolina 28806 Not yet recruiting
Local Institution - 0688 Easton Pennsylvania 18045 Withdrawn
Local Institution - 0376 Hershey Pennsylvania 17033 Withdrawn
WellSpan Oncology Research York Pennsylvania 17403 Recruiting
Local Institution - 0681 Greenville South Carolina 29605 Withdrawn
St Francis Cancer Center Greenville South Carolina 29607 Recruiting
SCRI Oncology Partners Nashville Tennessee 37203 Recruiting
Local Institution - 0697 Nashville Tennessee 37212 Not yet recruiting
Texas Oncology Sammons Cancer Center Dallas Texas 75246 Recruiting
University Of Texas Medical Branch At Galveston Galveston Texas 77555 Recruiting
Oncology & Hematology of South Texas Laredo Texas 78041 Recruiting
Texas Oncology - San Antonio San Antonio Texas 78217 Recruiting
Texas Oncology - Northeast Texas Tyler Texas 75702 Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 297 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT06875310, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Oct 13, 2026 · Synced Oct 16, 2026

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Open the official record

The complete public registry record, listed eligibility criteria, and available contact information for NCT06875310 live on ClinicalTrials.gov.

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