Study of Daraxonrasib (RMC-6236) in Patients With RAS Mutated NSCLC (RASolve 301)

ClinicalTrials.gov ID: NCT06881784

Public ClinicalTrials.gov record NCT06881784. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Sep 6, 2026, 6:45 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

RASolve 301: Phase 3 Multicenter, Open Label, Randomized Study of RMC-6236 Versus Docetaxel in Patients With Previously Treated Locally Advanced or Metastatic RAS[MUT] NSCLC

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

The purpose of this study is to evaluate the safety and efficacy of a novel RAS(ON) inhibitor compared to docetaxel.

Study identification

NCT ID: NCT06881784
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: Revolution Medicines, Inc.; Industry
Enrollment: 590 participants

Conditions and interventions

Conditions

Interventions

daraxonrasib Drug
docetaxel Drug

Drug

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: May 5, 2025
Primary completion: Nov 30, 2027
Completion: Nov 30, 2030
Last update posted: Aug 26, 2026

2025 – 2030

United States locations

U.S. sites: 43
U.S. states: 24
U.S. cities: 40

Facility	City	State	ZIP	Site status
Alabama Oncology	Birmingham	Alabama	35243	Recruiting
MemorialCare Long Beach Medical Center	Long Beach	California	90806	Recruiting
Yale University, Smillow Cancer Center	New Haven	Connecticut	06519	Recruiting
Florida Cancer Specialists & Research Institute - South	Fort Myers	Florida	33901	Recruiting
BRCR Global	Plantation	Florida	33322	Recruiting
Cancer Care Centers of Breevard	Rockledge	Florida	32955	Recruiting
Florida Cancer Specialists & Research Institute - North	St. Petersburg	Florida	33705	Recruiting
Cleveland Clinic Martin North	Stuart	Florida	34994	Recruiting
Florida Cancer Specialists & Research Institute - East	West Palm Beach	Florida	33401	Recruiting
University Cancer and Blood Center	Athens	Georgia	30607	Recruiting
Piedmont Healthcare, Inc	Atlanta	Georgia	30318	Recruiting
Winship Cancer Institute	Atlanta	Georgia	30322	Recruiting
Center for Care and Discovery	Chicago	Illinois	60637	Recruiting
University of Iowa Health Care Cancer Services Quad Cities	Bettendorf	Iowa	52722	Recruiting
University of Iowa Hospitals & Clinics	Iowa City	Iowa	52242	Recruiting
University of Iowa Health Care, Mission Cancer + Blood	Waukee	Iowa	50263	Recruiting
The University of Kansas Cancer Center	Westwood	Kansas	66205	Recruiting
Johns Hopkins University of Medicine	Baltimore	Maryland	21224	Recruiting
Karmanos Cancer Institute	Detroit	Michigan	48201	Recruiting
Henry Ford Health	Detroit	Michigan	48202	Recruiting
Washington University School of Medicine - Siteman Cancer Center	St Louis	Missouri	63110	Recruiting
St. Vincent Frontier Cancer Center	Billings	Montana	59102	Recruiting
Dartmouth-Hitchcock Medical Center	Lebanon	New Hampshire	03756	Recruiting
John Theurer Cancer Center at Hackensack UMC	Hackensack	New Jersey	07601	Recruiting
Morristown Medical Center (MMCORC)	Morristown	New Jersey	07960	Recruiting
Roswell Park Cancer Institute	Buffalo	New York	14263	Recruiting
Memorial Sloan Kettering Cancer Center	New York	New York	10065	Recruiting
Montefiore Medical Center	The Bronx	New York	10461	Recruiting
UNC Lineberger Comprehensive Cancer Center at University of North Carolina	Chapel Hill	North Carolina	27599	Recruiting
TriHealth Cancer & Blood Institute Research	Cincinnati	Ohio	45220	Recruiting
Taylor Cancer Research Center	Maumee	Ohio	43537	Recruiting
Oncology Associates of Oregon PC	Eugene	Oregon	97401	Recruiting
Penn State Milton S. Hershey Medical Center	Hershey	Pennsylvania	17033	Recruiting
Avera Saint Luke's Hospital	Aberdeen	South Dakota	57401	Recruiting
Avera Cancer Institute	Sioux Falls	South Dakota	57105	Recruiting
SCRI Oncology Partners - Tennessee	Nashville	Tennessee	37203	Recruiting
Texas Oncology - South Austin	Austin	Texas	78745	Recruiting
Texas Oncology Dallas	Dallas	Texas	75251	Recruiting
MD Anderson Cancer Center	Houston	Texas	77030	Recruiting
Texas Oncology - Gulf Coast	The Woodlands	Texas	77380	Recruiting
Utah Cancer Specialists	Salt Lake City	Utah	84106	Recruiting
Huntsman Cancer Institute	Salt Lake City	Utah	84112	Recruiting
Virginia Cancer Specialists	Fairfax	Virginia	22031	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 110 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT06881784, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Aug 26, 2026 · Synced Sep 6, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT06881784 live on ClinicalTrials.gov.

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