A Study to Assess Anti-Tumor Activity of Intravenously (IV) Infused Carboplatin With Mirvetuximab Soravtansine in Participants With Newly Diagnosed Folate Receptor Alpha (FRα)Expressing Advanced-Stage Serous Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Cancer.
Public ClinicalTrials.gov record NCT06890338. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Single-Arm, Phase 2 Study of Neoadjuvant Carboplatin and Mirvetuximab Soravtansine in Subjects With FRα-Expressing Advanced-Stage Serous Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Cancer
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Cancer is a condition where cells in a specific part of body grow and reproduce uncontrollably. The purpose of this study is to assess the safety and efficacy of neoadjuvant carboplatin and mirvetuximab soravtansine in participants with folate receptor alpha (FRα) -expressing advanced-stage serous epithelial ovarian, fallopian tube or primary peritoneal cancer (EOC). Mirvetuximab Soravtansine (MIRV) is an investigational antibody drug conjugate designed to selectively kill cancer cells. The antibody (protein) part of MIRV targets tumors by delivering a cell-killing drug to cancer cells carrying a protein called folate receptor alpha (FRα). This is a single arm study in adult participants with advanced-stage Fédération Internationale de Gynécologie et d'Obstétrique (FIGO) III-IV FRα-expressing serous EOC. Around 140 participants will be enrolled in the study at approximately 80 sites in the United States. Participants will receive intravenous infusion of MIRV in combination with carboplatin on day 1 of each cycle, every 21 days for up to 6 - 9 Cycles. The total study duration will be approximately 3 years . There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at a hospital or clinic and may require frequent medical assessments, blood tests, and scans.
Study identification
- NCT ID
- NCT06890338
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 140 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- Female
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 20, 2025
- Primary completion
- Jan 31, 2030
- Completion
- Jan 31, 2030
- Last update posted
- Aug 31, 2026
2025 – 2030
United States locations
- U.S. sites
- 69
- U.S. states
- 28
- U.S. cities
- 64
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham (UAB) Hospital /ID# 274793 | Birmingham | Alabama | 35294 | Recruiting |
| Usa Mitchell Cancer Institute /ID# 276022 | Mobile | Alabama | 36604 | Recruiting |
| University of California Los Angeles Medical Center /ID# 274566 | Los Angeles | California | 90095 | Recruiting |
| Scripps Md Anderson - Prebys Cancer Center /ID# 276891 | San Diego | California | 92103 | Recruiting |
| California Pacific Medical Center - Van Ness Campus /ID# 275329 | San Francisco | California | 94109 | Recruiting |
| Ridley Tree Cancer Center /ID# 275219 | Santa Barbara | California | 93105 | Active, not recruiting |
| Danbury Hospital, Western Connecticut Health Network /ID# 274783 | Danbury | Connecticut | 06810 | Recruiting |
| Yale University School of Medicine /ID# 275794 | New Haven | Connecticut | 06510 | Recruiting |
| Norwalk Hospital /ID# 274561 | Norwalk | Connecticut | 06856 | Recruiting |
| Jupiter Medical Center /ID# 276616 | Jupiter | Florida | 33458 | Recruiting |
| Mount Sinai Medical Center /ID# 274868 | Miami Beach | Florida | 33140 | Recruiting |
| Rush Md Anderson Cancer Center /ID# 274926 | Chicago | Illinois | 60607 | Recruiting |
| University of Chicago Medical Center /ID# 274796 | Chicago | Illinois | 60637 | Recruiting |
| OSF St. Francis Medical Center /ID# 274752 | Peoria | Illinois | 61637-0001 | Recruiting |
| Carle Foundation Hospital /ID# 276470 | Urbana | Illinois | 61801 | Recruiting |
| Parkview Research Center /ID# 274338 | Fort Wayne | Indiana | 46845 | Recruiting |
| Indiana University Melvin and Bren Simon Cancer Center /ID# 275492 | Indianapolis | Indiana | 46202 | Recruiting |
| Baptist Health Lexington /ID# 275218 | Lexington | Kentucky | 40503 | Recruiting |
| Norton Cancer Institute - St. Matthews /ID# 276173 | Louisville | Kentucky | 40207 | Recruiting |
| Women'S Cancer Care /ID# 276469 | Covington | Louisiana | 70433 | Recruiting |
| University Medical Center New Orleans /ID# 274755 | New Orleans | Louisiana | 70112 | Recruiting |
| Trials 365 /ID# 274310 | Shreveport | Louisiana | 71103 | Recruiting |
| University of Maryland, Baltimore /ID# 275308 | Baltimore | Maryland | 21201 | Recruiting |
| Holy Cross Hospital /ID# 275872 | Silver Spring | Maryland | 20910 | Recruiting |
| University of Minnesota - Minneapolis /ID# 275718 | Minneapolis | Minnesota | 55455-0341 | Recruiting |
| Metro Minnesota Community Oncology Research Consortium (MMCORC) /ID# 274780 | Saint Louis Park | Minnesota | 55416 | Recruiting |
| University Of Mississippi Medical Center /ID# 276342 | Jackson | Mississippi | 39216 | Recruiting |
| Cox Medical Center South /ID# 274826 | Springfield | Missouri | 65807 | Recruiting |
| Mercy David C. Pratt Cancer Center /ID# 275655 | St Louis | Missouri | 63141 | Recruiting |
| The Center Of Hope /ID# 274313 | Reno | Nevada | 89511 | Recruiting |
| Dartmouth-Hitchcock Medical Center /ID# 274676 | Lebanon | New Hampshire | 03756 | Recruiting |
| John Theurer Cancer Center /ID# 275756 | Hackensack | New Jersey | 07601 | Recruiting |
| Rutgers Cancer Institute of New Jersey /ID# 274358 | New Brunswick | New Jersey | 08901 | Recruiting |
| Holy Name Medical Center /ID# 276240 | Teaneck | New Jersey | 07666 | Recruiting |
| Optimum Clinical Research Group /ID# 274583 | Albuquerque | New Mexico | 87109 | Recruiting |
| Imbert Cancer Center /ID# 275634 | Bay Shore | New York | 11706 | Recruiting |
| Northwell Health Cancer Institute At Huntington /ID# 276814 | Greenlawn | New York | 11740 | Recruiting |
| Northwell Health Center for Advanced Medicine. /ID# 275641 | Lake Success | New York | 11042 | Recruiting |
| Northwell Health Queens Cancer Center /ID# 274850 | Rego Park | New York | 11374 | Recruiting |
| University of North Carolina Medical Center /ID# 275307 | Chapel Hill | North Carolina | 27514 | Recruiting |
| Atrium Health Levine Cancer Institute /ID# 274557 | Charlotte | North Carolina | 28204 | Recruiting |
| East Carolina University - Brody School of Medicine /ID# 275770 | Greenville | North Carolina | 27834 | Recruiting |
| Atrium Health Wake Forest Baptist Medical Center /ID# 276952 | Winston-Salem | North Carolina | 27157 | Recruiting |
| Sanford Fargo Medical Center - Fargo /ID# 275489 | Fargo | North Dakota | 58102 | Recruiting |
| Metrohealth Medical Center - Cleveland /ID# 276664 | Cleveland | Ohio | 44109 | Recruiting |
| Cleveland Clinic - Cleveland /ID# 276133 | Cleveland | Ohio | 44195 | Recruiting |
| Cleveland Clinic - Cleveland /ID# 278273 | Cleveland | Ohio | 44195 | Recruiting |
| Cleveland Clinic - Cleveland /ID# 278274 | Cleveland | Ohio | 44195 | Recruiting |
| The Mark H Zangmeister Center /ID# 275106 | Columbus | Ohio | 43219 | Recruiting |
| Kettering Medical Center /ID# 274365 | Kettering | Ohio | 45429 | Recruiting |
| Oncology Associates of Oregon, P.C. /ID# 275006 | Eugene | Oregon | 97401 | Recruiting |
| Compass Oncology - West - Tigard /ID# 275101 | Tigard | Oregon | 97223 | Recruiting |
| St. Lukes University Hospital /ID# 274362 | Bethlehem | Pennsylvania | 18015 | Recruiting |
| University of Pennsylvania - Perelman Center for Advanced Medicine /ID# 275612 | Philadelphia | Pennsylvania | 19104 | Recruiting |
| Women & Infants Hospital /ID# 274716 | Providence | Rhode Island | 02905 | Recruiting |
| Sanford Cancer Center /ID# 274901 | Sioux Falls | South Dakota | 57104 | Recruiting |
| Avera Cancer Institute - Sioux Falls /ID# 276226 | Sioux Falls | South Dakota | 57105 | Recruiting |
| Texas Oncology - Austin Central /ID# 275046 | Austin | Texas | 78731 | Recruiting |
| Texas Oncology - Fort Worth Cancer Center /ID# 275043 | Fort Worth | Texas | 76104 | Recruiting |
| Houston Methodist Hospital /ID# 274568 | Houston | Texas | 77030 | Recruiting |
| Texas Oncology - San Antonio Medical Center - Research Drive /ID# 275090 | San Antonio | Texas | 78240 | Recruiting |
| Texas Oncology - The Woodlands /ID# 275015 | The Woodlands | Texas | 77380 | Recruiting |
| Texas Oncology - Northeast Texas /ID# 275057 | Tyler | Texas | 75702 | Recruiting |
| UVA Health University Hospital /ID# 275309 | Charlottesville | Virginia | 22903 | Recruiting |
| Inova Schar Cancer Institute - Fairfax - Innovation Park Drive /ID# 276456 | Fairfax | Virginia | 22031 | Recruiting |
| Virginia Oncology Associates- Norfolk (Brock) /ID# 275227 | Norfolk | Virginia | 23502-2800 | Recruiting |
| Carilion Roanoke Memorial Hospital /ID# 274684 | Roanoke | Virginia | 24014 | Recruiting |
| Providence Sacred Heart Medical Center & Children'S Hospital /ID# 274585 | Spokane | Washington | 99204 | Recruiting |
| West Virginia University School of Medicine /ID# 274556 | Morgantown | West Virginia | 26506 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06890338, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 31, 2026 · Synced Sep 6, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06890338 live on ClinicalTrials.gov.