ClinicalTrials.gov record
A Clinical Study of Zilovertamab Vedotin (MK-2140) Plus Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Polatuzumab Vedotin Plus R-CHP in People With Diffuse Large B-cell Lymphoma (DLBCL) (MK-2140-011/waveLINE-011)
ClinicalTrials.gov ID: NCT06890884
Public ClinicalTrials.gov record NCT06890884. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced May 10, 2026, 9:42 AM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Open-label, Multicenter, Phase 2 Study Evaluating the Efficacy and Safety of Zilovertamab Vedotin (MK-2140) Plus R-CHP Versus Polatuzumab Vedotin Plus R-CHP in Treatment-naïve Participants With GCB Subtype of Diffuse Large B-cell Lymphoma (DLBCL)
Study identification
- NCT ID
- NCT06890884
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- Merck Sharp & Dohme LLC
- Industry
- Enrollment
- 594 participants
Conditions and interventions
Conditions
Interventions
- Cyclophosphamide Drug
- Doxorubicin Drug
- Polatuzumab vedotin Biological
- Prednisolone Drug
- Prednisone Drug
- Rescue Medication Drug
- Rituximab Biological
- Rituximab Biosimilar Biological
- Zilovertamab vedotin Biological
Drug · Biological
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Apr 10, 2025
- Primary completion
- Dec 12, 2027
- Completion
- Dec 15, 2032
- Last update posted
- May 7, 2026
2025 – 2032
United States locations
- U.S. sites
- 69
- U.S. states
- 30
- U.S. cities
- 65
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Infirmary Cancer Care ( Site 0157) | Mobile | Alabama | 36607 | Recruiting |
| Ironwood Cancer & Research Centers ( Site 0204) | Chandler | Arizona | 85224 | Recruiting |
| Palo Verde Cancer Specialists ( Site 0105) | Glendale | Arizona | 85304 | Recruiting |
| Genesis Cancer and Blood Institute ( Site 0193) | Hot Springs | Arkansas | 71913 | Recruiting |
| Roy and Patricia Disney Family Cancer Center - Providence Saint Joseph Medical Center ( Site 0135) | Burbank | California | 91505 | Recruiting |
| City of Hope Comprehensive Cancer Center ( Site 0191) | Duarte | California | 91010 | Recruiting |
| Bass Medical Group ( Site 0123) | Walnut Creek | California | 94598 | Recruiting |
| Rocky Mountain Cancer Centers (RMCC) ( Site 8001) | Aurora | Colorado | 80012 | Recruiting |
| Colorado West Healthcare System-Grand Valley Oncology ( Site 0165) | Grand Junction | Colorado | 81505 | Recruiting |
| Medical Oncology Hematology Consultants (MOHC) ( Site 8007) | Newark | Delaware | 19713 | Recruiting |
| Georgetown University Medical Center ( Site 0117) | Washington D.C. | District of Columbia | 20007 | Recruiting |
| Boca Raton Regional Hospital-Lynn Cancer Institute ( Site 0130) | Boca Raton | Florida | 33486 | Recruiting |
| Baptist MD Anderson Cancer Center ( Site 0176) | Jacksonville | Florida | 32207 | Recruiting |
| Mount Sinai Cancer Center ( Site 0140) | Miami Beach | Florida | 33140 | Recruiting |
| Mid Florida Hematology and Oncology Center ( Site 0152) | Orange City | Florida | 32763 | Recruiting |
| Beacon Cancer Care ( Site 0142) | Post Falls | Idaho | 83854 | Recruiting |
| University of Chicago Medical Center ( Site 0126) | Chicago | Illinois | 60637 | Recruiting |
| Illinois Cancer Care ( Site 7005) | Peoria | Illinois | 61615 | Recruiting |
| University of Iowa-Holden Comprehensive Cancer Center ( Site 0139) | Iowa City | Iowa | 52242 | Recruiting |
| Mission Blood & Cancer Care ( Site 0114) | Waukee | Iowa | 50263 | Recruiting |
| Saint Elizabeth Medical Center Edgewood ( Site 0141) | Edgewood | Kentucky | 41017 | Recruiting |
| Baptist Health Hardin ( Site 0154) | Elizabethtown | Kentucky | 42701 | Recruiting |
| Baptist Health Lexington ( Site 0127) | Lexington | Kentucky | 40503 | Recruiting |
| Norton Women's and Children's Hospital-Norton Cancer Institute - St. Matthews ( Site 0185) | Louisville | Kentucky | 40207 | Recruiting |
| Our Lady of the Lake Physician Group-Medical Oncology ( Site 0180) | Baton Rouge | Louisiana | 70808 | Recruiting |
| Ochsner LSU Health - Monroe Medical Center, Family Medicine Clinic ( Site 0209) | Monroe | Louisiana | 71202 | Recruiting |
| Ochsner Clinic Foundation ( Site 0189) | New Orleans | Louisiana | 70121 | Recruiting |
| Louisiana State University Health Sciences Shreveport ( Site 0195) | Shreveport | Louisiana | 71103 | Recruiting |
| Dana Farber Cancer Institute ( Site 0111) | Boston | Massachusetts | 02215 | Recruiting |
| Minnesota Oncology Hematology (MNO) ( Site 8004) | Burnsville | Minnesota | 55337 | Recruiting |
| Bozeman Health Deaconess Hospital ( Site 0183) | Bozeman | Montana | 59715 | Recruiting |
| NHO Revive Research Institute, LLC ( Site 0121) | Lincoln | Nebraska | 68506 | Recruiting |
| University Of Nebraska Medical Center ( Site 0110) | Omaha | Nebraska | 68198 | Recruiting |
| Atlantic Health Morristown Medical Center ( Site 0163) | Morristown | New Jersey | 07960 | Recruiting |
| Valley Health Systems - Ridgewood Campus ( Site 0125) | Paramus | New Jersey | 07652 | Recruiting |
| Erie County Medical Center ( Site 0175) | Buffalo | New York | 14215 | Recruiting |
| Roswell Park Cancer Institute ( Site 0192) | Buffalo | New York | 14263 | Recruiting |
| Perlmutter Cancer Center at NYU Langone Hospital - Long Island ( Site 0208) | Mineola | New York | 11501 | Recruiting |
| Laura and Isaac Perlmutter Cancer Center at NYU Langone ( Site 0108) | New York | New York | 10016 | Recruiting |
| SUNY Upstate Cancer Center ( Site 0178) | Syracuse | New York | 13210 | Recruiting |
| Clinical Research Alliance ( Site 0122) | Westbury | New York | 11590 | Recruiting |
| University of North Carolina Medical Center ( Site 0136) | Chapel Hill | North Carolina | 27514 | Recruiting |
| Novant Health Presbyterian Medical Center ( Site 0177) | Charlotte | North Carolina | 28204 | Recruiting |
| Novant Health Forsyth Medical Center ( Site 0206) | Winston-Salem | North Carolina | 27103 | Recruiting |
| University of Cincinnati Medical Center ( Site 0156) | Cincinnati | Ohio | 45219 | Recruiting |
| University Hospitals of Cleveland ( Site 0155) | Cleveland | Ohio | 44106 | Recruiting |
| Fairview Hospital-Moll Cancer Center ( Site 0198) | Cleveland | Ohio | 44111 | Recruiting |
| Cleveland Clinic Main ( Site 0101) | Cleveland | Ohio | 44195 | Recruiting |
| Cleveland Clinic - Hillcrest Hospital-Hillcrest Hospital Cancer Center ( Site 0199) | Mayfield Heights | Ohio | 44124 | Recruiting |
| Providence Portland Medical Center ( Site 0120) | Portland | Oregon | 97213 | Recruiting |
| Providence Oncology and Hematology Clinic Westside ( Site 0179) | Portland | Oregon | 97225 | Recruiting |
| Temple University Hospital ( Site 0133) | Philadelphia | Pennsylvania | 19140 | Recruiting |
| Alliance Cancer Specialists (ACS) ( Site 8010) | Sellersville | Pennsylvania | 18960 | Recruiting |
| Cancer Care Associates Of York ( Site 0174) | York | Pennsylvania | 17403 | Recruiting |
| Medical University of South Carolina ( Site 0153) | Charleston | South Carolina | 29425 | Recruiting |
| Tennessee Cancer Specialists ( Site 7004) | Knoxville | Tennessee | 37909 | Recruiting |
| SCRI Oncology Partners ( Site 7002) | Nashville | Tennessee | 37203 | Recruiting |
| Texas Oncology - West Texas ( Site 8008) | Amarillo | Texas | 79124 | Recruiting |
| Texas Oncology - Central/South Texas ( Site 8006) | Austin | Texas | 78705 | Recruiting |
| Texas Oncology - Northeast Texas ( Site 8002) | Palestine | Texas | 75801 | Recruiting |
| Texas Oncology - San Antonio ( Site 8009) | San Antonio | Texas | 78240 | Recruiting |
| The University of Texas Health Science Center at Tyler dba UT Health East Texas HOPE Cancer Center ( Site 0145) | Tyler | Texas | 75701 | Completed |
| Intermountain Medical Center ( Site 0182) | Murray | Utah | 84107 | Recruiting |
| Intermountain Healthcare - St. George ( Site 0203) | St. George | Utah | 84790 | Recruiting |
| Virginia Cancer Specialists, PC ( Site 8003) | Manassas | Virginia | 20110 | Recruiting |
| VCU Health Adult Outpatient Pavillion ( Site 0138) | Richmond | Virginia | 23219 | Recruiting |
| Northwest Cancer Specialists (Compass Oncology) ( Site 8000) | Vancouver | Washington | 98684 | Recruiting |
| SSM Health Dean Medical Group ( Site 0106) | Madison | Wisconsin | 53715 | Recruiting |
| Medical College of Wisconsin ( Site 0103) | Milwaukee | Wisconsin | 53226 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 54 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06890884, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 7, 2026 · Synced May 10, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06890884 live on ClinicalTrials.gov.