A Clinical Study to Investigate the Efficacy and Safety of an Investigational Combination Therapy With BNT324 and BNT327 in Patients With Advanced Lung Cancer
Public ClinicalTrials.gov record NCT06892548. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase Ib/II, Multi-site, Open-label, Two-part Trial to Evaluate the Efficacy, Safety, Pharmacokinetics, and Recommended Combination Dose of BNT324 With BNT327 in Participants With Advanced Lung Cancer
Study identification
- NCT ID
- NCT06892548
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 1, Phase 2
- Lead sponsor
- BioNTech SE
- Industry
- Enrollment
- 594 participants
Conditions and interventions
Conditions
Interventions
- BNT324 Biological
- BNT327 Biological
Biological
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 1, 2025
- Primary completion
- Jul 31, 2027
- Completion
- May 31, 2031
- Last update posted
- Apr 14, 2026
2025 – 2031
United States locations
- U.S. sites
- 15
- U.S. states
- 10
- U.S. cities
- 14
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Mayo Clinic Arizona | Phoenix | Arizona | 13400 | Recruiting |
| Precision NextGen Oncology and Research Center | Beverly Hills | California | 90212 | Recruiting |
| Cedars Sinai Medical Center | Los Angeles | California | 90048 | Recruiting |
| UCLA - David Geffen School of Medicine | Santa Monica | California | 90404 | Recruiting |
| Mayo Clinic in Florida | Jacksonville | Florida | 32224 | Recruiting |
| University of Iowa Hospitals & Clinics PARENT | Iowa City | Iowa | 52242 | Recruiting |
| Mayo Clinic-Rochester | Rochester | Minnesota | 55905 | Recruiting |
| John Theurer Cancer Center at Hackensack UMC | Hackensack | New Jersey | 07601 | Recruiting |
| Memorial Sloan Kettering Cancer Center (MSKCC) | New York | New York | 10021 | Recruiting |
| Icahn School of Medicine at Mount Sinai PRIME | New York | New York | 10029 | Recruiting |
| Cleveland Clinic Taussig Cancer Institute Case Comprehensive Cancer Center | Cleveland | Ohio | 44195 | Recruiting |
| Texas Oncology - DFW | Dallas | Texas | 75246 | Recruiting |
| MD Anderson Cancer Center | Houston | Texas | 77030 | Recruiting |
| Texas Oncology - Northeast | Tyler | Texas | 75702 | Recruiting |
| Virginia Cancer Specialists | Fairfax | Virginia | 22031 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 43 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06892548, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 14, 2026 · Synced May 6, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06892548 live on ClinicalTrials.gov.