ANCHOR Study: A Study to Assess the Safety and Efficacy of ABBV-CLS-628 in Adult Participants With Autosomal Dominant Polycystic Kidney Disease (ADPKD)
Public ClinicalTrials.gov record NCT06902558. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2, Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety and Efficacy of ABBV-CLS-628 in Adult Subjects With Autosomal Dominant Polycystic Kidney Disease (ADPKD)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is the most common genetic cause of kidney disease that causes fluid-filled cysts to develop in the kidneys. The purpose of this study is to assess the safety and efficacy of ABBV-CLS-628 for the treatment of ADPKD in adult participants. ABBV-CLS-628 is an investigational drug being developed for the treatment of ADPKD. Participants are placed in 1 of 4 groups, called treatment arms. Each group receives a different treatment. There is a 1 in 4 chance that participants will be assigned to placebo. Around 240 adult participants with ADPKD will be enrolled at approximately 100 sites worldwide. Participants will receive IntraVenous ABBV-CLS-628 or placebo every 4 weeks for 92 weeks. Participants will be followed for up to 15 weeks. There may be higher treatment burden for participants in this trial compared to their standard of care . Participants will attend regular visits during the study at a hospital or clinic. The effect of the treatment will be checked by medical assessments, blood tests, checking for side effects and completing questionnaires.
Study identification
- NCT ID
- NCT06902558
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 240 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 55 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 8, 2025
- Primary completion
- Jul 31, 2029
- Completion
- Jul 31, 2029
- Last update posted
- Aug 31, 2026
2025 – 2029
United States locations
- U.S. sites
- 40
- U.S. states
- 20
- U.S. cities
- 37
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35294 | Recruiting |
| Valiance Clinical Research - Huntington Park | Huntington Park | California | 90255 | Recruiting |
| Academic Medical Research Institute (AMRI) - Los Angeles | Los Angeles | California | 90022 | Recruiting |
| UC Irvine Medical Center | Orange | California | 92868-3201 | Recruiting |
| National Institute of Clinical Research - Pomona | Pomona | California | 91768 | Recruiting |
| University Of California, San Francisco | San Francisco | California | 94143-2202 | Recruiting |
| University of California Los Angeles Medical Center | Santa Monica | California | 90404 | Not yet recruiting |
| Yale University School of Medicine | New Haven | Connecticut | 06510 | Recruiting |
| Horizon Research Group - Coral Gables | Coral Gables | Florida | 33134 | Withdrawn |
| South Florida Research Institute | Fort Lauderdale | Florida | 33313 | Recruiting |
| Nature Coast Clinical Research - Inverness | Inverness | Florida | 34452-4717 | Recruiting |
| Mayo Clinic Hospital Jacksonville | Jacksonville | Florida | 32224 | Recruiting |
| Panax Clinical Research | Miami | Florida | 33014 | Recruiting |
| University of Miami Don Suffer Clinical Research Building | Miami | Florida | 33136 | Recruiting |
| Infigo Clinical Research | Sanford | Florida | 32771 | Recruiting |
| Emory University School Of Medicine - Atlanta | Atlanta | Georgia | 30322 | Recruiting |
| CARE-Boise Kidney | Boise | Idaho | 83706 | Recruiting |
| CARE Institute - Idaho Falls | Idaho Falls | Idaho | 83404 | Recruiting |
| Northwestern University Feinberg School of Medicine | Chicago | Illinois | 60611-2927 | Recruiting |
| University of Iowa | Iowa City | Iowa | 52242 | Recruiting |
| University of Kansas Medical Center | Kansas City | Kansas | 66160 | Recruiting |
| Tufts Medical Center | Boston | Massachusetts | 02111-1552 | Recruiting |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215 | Recruiting |
| University Of Michigan | Ann Arbor | Michigan | 48109-5000 | Recruiting |
| St. Clair Nephrology | Shelby | Michigan | 48315 | Recruiting |
| Mayo Clinic Hospital - Rochester | Rochester | Minnesota | 55905 | Recruiting |
| Washington University School of Medicine - St Louis | St Louis | Missouri | 63110 | Recruiting |
| Rogosin Institute | New York | New York | 10021 | Not yet recruiting |
| Icahn School of Medicine at Mount Sinai | New York | New York | 10029 | Recruiting |
| University of North Carolina at Chapel Hill | Chapel Hill | North Carolina | 27599-0001 | Recruiting |
| Brookview Hills Research Associates | Winston-Salem | North Carolina | 27103 | Recruiting |
| Northeast Clinical Research Center | Bethlehem | Pennsylvania | 18017 | Recruiting |
| University of Pennsylvania | Philadelphia | Pennsylvania | 19104 | Recruiting |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | Not yet recruiting |
| Nephrology Associates - Chattanooga - East Third Street | Chattanooga | Tennessee | 37404 | Recruiting |
| Knoxville Kidney Center | Knoxville | Tennessee | 37923 | Recruiting |
| The Vanderbilt University Medical Center (VUMC) | Nashville | Tennessee | 37212 | Not yet recruiting |
| Arlington Nephrology | Arlington | Texas | 76015 | Withdrawn |
| Renal Disease Research Institute | Fort Worth | Texas | 76104 | Recruiting |
| Swedish Medical Center - Seattle | Seattle | Washington | 98104 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 51 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06902558, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 31, 2026 · Synced Sep 10, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06902558 live on ClinicalTrials.gov.