REVEAL: A Phase 3 Study of ION582 in Angelman Syndrome

ClinicalTrials.gov ID: NCT06914609

Public ClinicalTrials.gov record NCT06914609. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Apr 26, 2026, 5:17 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

Phase 3 Study of the Efficacy and Safety of ION582 in Children and Adults With Angelman Syndrome

Study identification

NCT ID: NCT06914609
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: Ionis Pharmaceuticals, Inc.; Industry
Enrollment: 158 participants

Conditions and interventions

Conditions

Angelman Syndrome

Interventions

ION582 Drug
Placebo Drug

Drug

Eligibility (public fields only)

Age range: 2 Years to 50 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Jun 9, 2025
Primary completion: Jul 31, 2027
Completion: Mar 31, 2030
Last update posted: Apr 23, 2026

2025 – 2030

United States locations

U.S. sites: 15
U.S. states: 14
U.S. cities: 15

Facility	City	State	ZIP	Site status
Cedars-Sinai Medical Center	Los Angeles	California	90048	Recruiting
Rady Children's Hospital	San Diego	California	92123	Recruiting
Colorado Children's Hospital Research Institute	Aurora	Colorado	80045	Recruiting
Children's National Hospital	Washington D.C.	District of Columbia	20011	Recruiting
Nicklaus Children's Hospital	Miami	Florida	33155	Recruiting
Children's Healthcare of Atlanta	Atlanta	Georgia	30329	Recruiting
Rush University Medical Center	Chicago	Illinois	60612	Recruiting
Boston Children's Hospital	Boston	Massachusetts	02115	Recruiting
Children's Mercy	Kansas City	Missouri	64108	Recruiting
Ichan School of Medicine at Mount Sinai	New York	New York	10029	Recruiting
University of North Carolina at Chapel Hill School of Medicine	Carrboro	North Carolina	27510	Recruiting
Nationwide Children's Hospital	Columbus	Ohio	43205	Recruiting
Children's Hospital of Philadelphia	Philadelphia	Pennsylvania	19104	Recruiting
Vanderbilt Clinical Research Center	Nashville	Tennessee	37232	Recruiting
Texas Children's Hospital	Houston	Texas	77030	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 23 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT06914609, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Apr 23, 2026 · Synced Apr 26, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT06914609 live on ClinicalTrials.gov.

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