A Study to Investigate the Treatment Effect of Subcutaneous Injections of Pentosan Polysulfate Sodium Compared With Placebo in Adult Participants With Knee Osteoarthritis Pain.
Public ClinicalTrials.gov record NCT06917404. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Randomised, Double-Blind, Placebo-Controlled Multi-Centre Study to Evaluate the Treatment Effect of Pentosan Polysulfate Sodium Compared to Placebo in Participants With Knee Osteoarthritis Pain
Study identification
- NCT ID
- NCT06917404
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Paradigm Biopharmaceuticals Ltd.
- Industry
- Enrollment
- 466 participants
Conditions and interventions
Conditions
Interventions
- Pentosan Polysulfate Sodium twice weekly Drug
- Placebo Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 28, 2025
- Primary completion
- Jun 30, 2027
- Completion
- Jun 30, 2027
- Last update posted
- May 7, 2026
2025 – 2027
United States locations
- U.S. sites
- 40
- U.S. states
- 11
- U.S. cities
- 36
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Onyx Clinical Research-Peoria | Peoria | Arizona | 85381 | Recruiting |
| Del Sol Research Management, LLC | Tucson | Arizona | 85715 | Recruiting |
| Orange County Research Institute | Anaheim | California | 92801 | Recruiting |
| Core Healthcare Group | Cerritos | California | 90703 | Recruiting |
| Triwest Research Center | Chula Vista | California | 91910 | Recruiting |
| Seaside Medical Group | Oceanside | California | 92058 | Recruiting |
| Paragon RX Clinical | Santa Ana | California | 92703 | Recruiting |
| Encompass Clinical Research | Spring Valley | California | 91978 | Recruiting |
| Focus Clinical Research | West Hills | California | 91307 | Recruiting |
| Clinical Research of West Florida - Clearwater | Clearwater | Florida | 33765 | Recruiting |
| GNP Research | Cooper City | Florida | 33024 | Recruiting |
| Arrow Clinical Trials | Daytona Beach | Florida | 32117 | Recruiting |
| AGA Clinical Trials | Hialeah | Florida | 33012 | Recruiting |
| Evolution Clinical Trials | Miami | Florida | 33122 | Recruiting |
| Well Pharma Medical Research | Miami | Florida | 33173 | Recruiting |
| K2 Medical Research | Orlando | Florida | 32806 | Recruiting |
| Progressive Medical Research | Port Orange | Florida | 32127 | Recruiting |
| Phoenix Clinical Research | Tamarac | Florida | 33321 | Recruiting |
| Conquest Research | Winter Park | Florida | 32789 | Recruiting |
| Chicago Clinical Research, Inc | Chicago | Illinois | 60607 | Recruiting |
| Northwestern University | Chicago | Illinois | 60611 | Recruiting |
| Sinai Hospital of Baltimore | Baltimore | Maryland | 21215 | Recruiting |
| Profound Research | Farmington Hills | Michigan | 48334 | Recruiting |
| Insight Research Institute | Flint | Michigan | 48507 | Recruiting |
| Rochester Medical Group | Rochester Hills | Michigan | 48307 | Recruiting |
| Onyx Clinical Research - Rochester Hills | Troy | Michigan | 48085 | Recruiting |
| Physician Research Collaboration | Lincoln | Nebraska | 68516 | Recruiting |
| Alpine Healthcare Family Practice | Las Vegas | Nevada | 89109 | Recruiting |
| Drug Trials America | Hartsdale | New York | 10530 | Recruiting |
| Groth Pain & Spine - Long Island, NY | Mineola | New York | 11501 | Recruiting |
| IMA Clinical Research Manhattan | New York | New York | 10036 | Recruiting |
| Groth Pain and Spine Management | Smithtown | New York | 11787 | Recruiting |
| FutureSearch Trials of Neurology | Austin | Texas | 78731 | Recruiting |
| FutureSearch Trials of Dallas | Dallas | Texas | 75251 | Recruiting |
| Vilo Research Group | Houston | Texas | 77017 | Recruiting |
| DM Clinical Research | Houston | Texas | 77065 | Recruiting |
| Clinical Trial Network | Houston | Texas | 77074 | Recruiting |
| Epic Clinical Research | Lewisville | Texas | 75057 | Recruiting |
| Quality Research Inc. | San Antonio | Texas | 78209 | Recruiting |
| Rio Clinical Trials | Ogden | Utah | 84404 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 16 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06917404, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 7, 2026 · Synced May 9, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06917404 live on ClinicalTrials.gov.