A Study to Investigate the Treatment Effect of Subcutaneous Injections of Pentosan Polysulfate Sodium Compared With Placebo in Adult Participants With Knee Osteoarthritis Pain.
Public ClinicalTrials.gov record NCT06917404. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
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Official title
A Phase 3, Randomised, Double-Blind, Placebo-Controlled Multi-Centre Study to Evaluate the Treatment Effect of Pentosan Polysulfate Sodium Compared to Placebo in Participants With Knee Osteoarthritis Pain
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to measure the change in pain and function with subcutaneous injections of pentosan polysulfate sodium (PPS) compared with subcutaneous injections of placebo in participants with knee OA pain. Study details include: * The study duration will be up to 64 weeks. * The treatment duration will be 6 weeks. * The visit frequency will be twice weekly during treatment. * The visit/contact frequency will be every 4-6 weeks during the 52-week Follow-up period. * Approximately 466 participants will be enrolled into this study.
Study identification
- NCT ID
- NCT06917404
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 466 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 29, 2025 (Actual)
- Primary completion
- Jul 2027 (Estimated)
- Completion
- Jul 2027 (Estimated)
- Last update posted
- Sep 1, 2026
2025 – 2027
United States locations
- U.S. sites
- 41
- U.S. states
- 11
- U.S. cities
- 37
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Onyx Clinical Research-Peoria | Peoria | Arizona | 85381 | — |
| Del Sol Research Management, LLC | Tucson | Arizona | 85715 | — |
| Orange County Research Institute | Anaheim | California | 92801 | — |
| Core Healthcare Group | Cerritos | California | 90703 | — |
| Triwest Research Center | Chula Vista | California | 91910 | — |
| Seaside Medical Group | Oceanside | California | 92058 | — |
| Paragon RX Clinical | Santa Ana | California | 92703 | — |
| Encompass Clinical Research | Spring Valley | California | 91978 | — |
| Focus Clinical Research | West Hills | California | 91307 | — |
| Clinical Research of West Florida - Clearwater | Clearwater | Florida | 33765 | — |
| GNP Research | Cooper City | Florida | 33024 | — |
| Arrow Clinical Trials | Daytona Beach | Florida | 32117 | — |
| AGA Clinical Trials | Hialeah | Florida | 33012 | — |
| Evolution Clinical Trials | Miami | Florida | 33122 | — |
| Well Pharma Medical Research | Miami | Florida | 33173 | — |
| K2 Medical Research | Orlando | Florida | 32806 | — |
| Progressive Medical Research | Port Orange | Florida | 32127 | — |
| Phoenix Clinical Research | Tamarac | Florida | 33321 | — |
| Conquest Research | Winter Park | Florida | 32789 | — |
| Chicago Clinical Research, Inc | Chicago | Illinois | 60607 | — |
| Northwestern University | Chicago | Illinois | 60611 | — |
| Sinai Hospital of Baltimore | Baltimore | Maryland | 21215 | — |
| Profound Research | Farmington Hills | Michigan | 48334 | — |
| Insight Research Institute | Flint | Michigan | 48507 | — |
| Rochester Medical Group | Rochester Hills | Michigan | 48307 | — |
| Onyx Clinical Research - Rochester Hills | Troy | Michigan | 48085 | — |
| Physician Research Collaboration | Lincoln | Nebraska | 68516 | — |
| Alpine Healthcare Family Practice | Las Vegas | Nevada | 89109 | — |
| Drug Trials America | Hartsdale | New York | 10530 | — |
| Groth Pain & Spine - Long Island, NY | Mineola | New York | 11501 | — |
| IMA Clinical Research Manhattan | New York | New York | 10036 | — |
| Groth Pain and Spine Management | Smithtown | New York | 11787 | — |
| FutureSearch Trials of Neurology | Austin | Texas | 78731 | — |
| FutureSearch Trials of Dallas | Dallas | Texas | 75251 | — |
| El Paso Clinical Trials | El Paso | Texas | 79935 | — |
| Vilo Research Group | Houston | Texas | 77017 | — |
| DM Clinical Research | Houston | Texas | 77065 | — |
| Clinical Trial Network | Houston | Texas | 77074 | — |
| Epic Clinical Research | Lewisville | Texas | 75057 | — |
| Quality Research Inc. | San Antonio | Texas | 78209 | — |
| Rio Clinical Trials | Ogden | Utah | 84404 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 16 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06917404, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 1, 2026 · Synced Nov 8, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06917404 live on ClinicalTrials.gov.