A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Chronic Kidney Disease
Public ClinicalTrials.gov record NCT06926660. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase II Randomised, Double-blind, Parallel-group, Multicentre, International Trial to Investigate the Safety and Efficacy of Vicadrostat and Empagliflozin Administered With Simultaneous vs Staggered Initiation in Participants With Chronic Kidney Disease at Risk of Kidney Disease Progression
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study is open to adults with chronic kidney disease (CKD) that is at risk of getting worse. People who have taken a specific type of medication for kidney disease called SGLT2 inhibitor within 1 month before the study or have certain health conditions cannot take part in this study. The purpose of this study is to find out whether a medicine called vicadrostat, used in combination with another medicine called empagliflozin, works in people with chronic kidney disease. In this study, participants are randomly assigned to one of two groups. Participants have an equal chance of being assigned to either group. In one group, participants take the 2 study medicines, vicadrostat and empagliflozin, every day for 3 months. In the other group, participants take placebo and empagliflozin for the first 1.5 months, and then they take vicadrostat and empagliflozin together for the next 1.5 months. The study medicines are taken orally as tablets. Placebo tablets look like vicadrostat tablets but do not contain any medicine. Participants are in the study for about 4.5 months. During this time, they visit the study site multiple times. Doctors regularly test kidney function by measuring specific proteins in the blood and urine. The results are compared between the two groups to see whether there are differences between starting the study medicines at the same time or one after the other. The doctors also regularly check participants' health and take note of any unwanted effects.
Study identification
- NCT ID
- NCT06926660
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 492 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 18, 2025 (Actual)
- Primary completion
- Aug 14, 2026 (Actual)
- Completion
- Aug 14, 2026 (Actual)
- Last update posted
- Sep 30, 2026
2025 – 2026
United States locations
- U.S. sites
- 37
- U.S. states
- 19
- U.S. cities
- 36
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Apogee Clinical Research | Huntsville | Alabama | 35805 | — |
| Orange County Clinical Trials | Anaheim | California | 92801 | — |
| North America Research Institute | San Dimas | California | 91773 | — |
| Valiance Clinical Research-Tarzana-68237 | Tarzana | California | 91356 | — |
| Amicis Research Center - Valencia | Valencia | California | 91355 | — |
| Focus Clinical Research | West Hills | California | 91307 | — |
| Clinical Research of Brandon LLC | Brandon | Florida | 33511 | — |
| Hillcrest Medical Research | DeLand | Florida | 32720 | — |
| Encore Medical Research | Hollywood | Florida | 33024 | — |
| Finlay Medical Research Corp | Miami | Florida | 33126 | — |
| Total Research Group, LLC | Miami | Florida | 33126 | — |
| San Marcus Research Clinic, Inc. | Miami Lakes | Florida | 33014 | — |
| West Orange Endocrinology, PA | Ocoee | Florida | 34761 | — |
| Florida Kidney Physicians - Riverview/Brandon | Riverview | Florida | 33578 | — |
| Masters of Clinical Research, Inc | Augusta | Georgia | 30909 | — |
| Boise Kidney and Hypertension, PLLC | Boise | Idaho | 83706 | — |
| Research by Design, LLC | Chicago | Illinois | 60643 | — |
| Nephrology Associates of Northern Illinois and Indiana - Oak Brook | Hinsdale | Illinois | 60521 | — |
| Nephrology Associates of Northern Illinois and Indiana - Fort Wayne | Fort Wayne | Indiana | 46804 | — |
| Kansas Nephrology Research Institute, LLC | Wichita | Kansas | 67214 | — |
| Northwest Louisiana Nephrology | Shreveport | Louisiana | 71101 | — |
| Aa Mrc Llc | Flint | Michigan | 48504 | — |
| Michigan Kidney Consultants | Pontiac | Michigan | 48341 | — |
| Elixia MNA, LLC | City of Saint Peters | Missouri | 63376 | — |
| Healor Primary Care | Las Vegas | Nevada | 89102 | — |
| Endocrine Associates of Long Island | Smithtown | New York | 11787 | — |
| Durham Nephrology Associates | Durham | North Carolina | 27704 | — |
| Lucas Research, Inc. | Morehead City | North Carolina | 28557 | — |
| Brookview Hills Research Associates LLC | Winston-Salem | North Carolina | 27103 | — |
| Heritage Valley Medical Group | Beaver | Pennsylvania | 15009 | — |
| Southeast Renal Research Institute | Chattanooga | Tennessee | 37404 | — |
| Arlington Nephrology | Arlington | Texas | 76015 | — |
| Endocrine Associates | Houston | Texas | 77004 | — |
| Clinical Advancement Center, PLLC | San Antonio | Texas | 78212 | — |
| Javara Inc.-Stephenville-68996 | Stephenville | Texas | 76401 | — |
| Utah Kidney Research Institute | Salt Lake City | Utah | 84115 | — |
| Tidewater Physicians Multispecialty Group | Newport News | Virginia | 23606 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 120 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06926660, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 30, 2026 · Synced Oct 16, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06926660 live on ClinicalTrials.gov.