A Study to Evaluate the Long-term Efficacy and Safety of KarXT + KarX-EC for Agitation in Alzheimer's Disease (ADAGIO-3)

ClinicalTrials.gov ID: NCT06937229

Public ClinicalTrials.gov record NCT06937229. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 7, 2026, 11:01 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 3, Open-label Extension Study to Evaluate the Long-term Safety and Tolerability of KarXT + KarX-EC for the Treatment of Agitation Associated With Alzheimer's Disease (ADAGIO-3)

Study identification

NCT ID: NCT06937229
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: Bristol-Myers Squibb; Industry
Enrollment: 600 participants

Conditions and interventions

Conditions

Interventions

KarX-EC Drug
KarXT Drug

Drug

Eligibility (public fields only)

Age range: 55 Years to 90 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Dec 1, 2025
Primary completion: Jun 21, 2029
Completion: Jul 19, 2029
Last update posted: Apr 20, 2026

2025 – 2029

United States locations

U.S. sites: 48
U.S. states: 20
U.S. cities: 42

Facility	City	State	ZIP	Site status
Local Institution - 2609	Chandler	Arizona	85224	Not yet recruiting
Imaging Endpoints	Scottsdale	Arizona	85258	Recruiting
Local Institution - 1657	Anaheim	California	92805	Not yet recruiting
Local Institution - 2620	Canoga Park	California	91303	Not yet recruiting
Local Institution - 1637	La Jolla	California	92037	Not yet recruiting
Local Institution - 2625	Long Beach	California	90040	Not yet recruiting
Local Institution - 2607	Long Beach	California	90805	Not yet recruiting
Local Institution - 2642	Long Beach	California	90807	Not yet recruiting
Local Institution - 2613	Pasadena	California	91105	Not yet recruiting
Local Institution - 1662	Pomona	California	91767	Not yet recruiting
Local Institution - 1639	Torrance	California	90505	Not yet recruiting
Local Institution - 1651	Walnut Creek	California	94596	Not yet recruiting
Local Institution - 2602	Bonita Springs	Florida	34134-4154	Not yet recruiting
Local Institution - 2626	Hialeah	Florida	33012	Not yet recruiting
Local Institution - 1602	Miami	Florida	33122	Not yet recruiting
Local Institution - 1618	Miami	Florida	33135	Not yet recruiting
Local Institution - 1609	Miami	Florida	33166	Not yet recruiting
Nuovida Research Center	Miami	Florida	33186	Recruiting
Local Institution - 1635	Orlando	Florida	32807	Not yet recruiting
Progressive Medical Research	Port Orange	Florida	32127	Recruiting
IPTB Clinical Research	Tampa	Florida	33629	Recruiting
Local Institution - 1636	Gaithersburg	Maryland	20877	Not yet recruiting
Boston Center for Memory	Newton	Massachusetts	02459	Recruiting
Local Institution - 2615	Worcester	Massachusetts	01608	Not yet recruiting
Local Institution - 2618	Ann Arbor	Michigan	48105	Not yet recruiting
Local Institution - 1620	Troy	Michigan	48085	Not yet recruiting
Local Institution - 2256	Saint Paul	Minnesota	55130	Not yet recruiting
Local Institution - 2629	Hattiesburg	Mississippi	39402	Not yet recruiting
Local Institution - 2628	Las Vegas	Nevada	89030	Not yet recruiting
Local Institution - 1649	Las Vegas	Nevada	89119	Not yet recruiting
Local Institution - 1647	West Long Branch	New Jersey	07764	Not yet recruiting
Local Institution - 1656	New Windsor	New York	12553	Not yet recruiting
Local Institution - 2619	Staten Island	New York	10312	Not yet recruiting
Local Institution - 1658	Woodmere	New York	11598-1739	Not yet recruiting
West Clinical Research	Morehead City	North Carolina	28557	Recruiting
Local Institution - 2617	Blue Ash	Ohio	45242	Not yet recruiting
Local Institution - 1640	Tulsa	Oklahoma	74136	Not yet recruiting
Local Institution - 1653	Columbia	South Carolina	29205	Not yet recruiting
Epic Medical Research, LLC - Carrolton	Carrollton	Texas	75006	Recruiting
Local Institution - 2605	Cypress	Texas	77065	Not yet recruiting
Local Institution - 1643	El Paso	Texas	79912	Not yet recruiting
Local Institution - 2622	Mesquite	Texas	75150	Not yet recruiting
Local Institution - 2623	San Antonio	Texas	78229	Not yet recruiting
Pantheon Clinical Research, LLC	Bountiful	Utah	84010	Recruiting
Local Institution - 1646	Bennington	Vermont	05201-9810	Not yet recruiting
Local Institution - 1644	Seattle	Washington	98122	Not yet recruiting
Local Institution - 1654	Spokane	Washington	99201	Not yet recruiting
Local Institution - 2610	Milwaukee	Wisconsin	53226	Not yet recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 193 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT06937229, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Apr 20, 2026 · Synced May 7, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT06937229 live on ClinicalTrials.gov.

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