Zanzalintinib Versus Everolimus in Participants With Locally Advanced or Metastatic Neuroendocrine Tumors

ClinicalTrials.gov ID: NCT06943755

Public ClinicalTrials.gov record NCT06943755. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Sep 2, 2026, 5:33 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 2/3, Multicenter, Randomized Open-Label Study of Zanzalintinib vs Everolimus in Participants With Previously Treated, Unresectable, Locally Advanced or Metastatic Neuroendocrine Tumors

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

The primary purpose of this study is to assess the effectiveness of zanzalintinib compared to everolimus in participants with previously treated, unresectable, locally advanced or metastatic neuroendocrine tumors.

Study identification

NCT ID: NCT06943755
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 2, Phase 3
Lead sponsor: Exelixis; Industry
Enrollment: 440 participants

Conditions and interventions

Conditions

Interventions

Zanzalintinib Drug
Everolimus Drug

Drug

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Jul 20, 2025
Primary completion: Jun 29, 2029
Completion: Jun 29, 2029
Last update posted: Aug 25, 2026

2025 – 2029

United States locations

U.S. sites: 40
U.S. states: 25
U.S. cities: 40

Facility	City	State	ZIP	Site status
The University of Alabama at Birmingham	Birmingham	Alabama	35294	Recruiting
Mayo Clinic Hospital	Phoenix	Arizona	85054	Recruiting
The University of Arizona Cancer Center	Tucson	Arizona	85724	Recruiting
Cedars-Sinai Medical Center	Beverly Hills	California	90211	Recruiting
Norris Comprehensive Cancer Center	Los Angeles	California	90033	Recruiting
Stanford Cancer Center	Palo Alto	California	94305	Recruiting
UCLA Health - Santa Monica Cancer Care	Santa Monica	California	90404	Recruiting
Kaiser Permanente Medical Center	Vallejo	California	94589	Recruiting
Georgetown University	Washington D.C.	District of Columbia	20007	Recruiting
Mayo Clinic - Florida	Jacksonville	Florida	32224	Recruiting
AdventHealth Orlando	Orlando	Florida	32804	Recruiting
Moffitt Cancer Center	Tampa	Florida	33612	Recruiting
University of Kentucky Markey Cancer Center	Lexington	Kentucky	40536	Recruiting
East Jefferson General Hospital	Metairie	Louisiana	70006	Recruiting
Dana-Farber Cancer Institute	Boston	Massachusetts	02215	Recruiting
Henry Ford Cancer- Detroit	Detroit	Michigan	48202	Recruiting
The Cancer and Hematology Centers	Grand Rapids	Michigan	49546	Recruiting
Mayo Clinic	Rochester	Minnesota	55905	Recruiting
Siteman Cancer Center	St Louis	Missouri	63110	Recruiting
University of Nebraska Medical Center	Omaha	Nebraska	68198	Recruiting
University of New Mexico Comprehensive Cancer Center	Albuquerque	New Mexico	87131	Recruiting
Roswell Park Cancer Institute	Buffalo	New York	14263	Recruiting
Icahan School of Medicine at Mount Sinai	New York	New York	10029	Recruiting
University of Rochester Medical Center	Rochester	New York	14642	Recruiting
University of North Carolina at Chapel Hill	Chapel Hill	North Carolina	27599	Recruiting
Duke University Medical Center	Durham	North Carolina	27710	Recruiting
Sanford Roger Maris Cancer Center	Fargo	North Dakota	58102	Recruiting
University Hospitals Cleveland Medical Center	Cleveland	Ohio	44106	Recruiting
The Ohio State University Comprehensive Cancer Center	Columbus	Ohio	43221	Recruiting
Oregon Health and Science University	Portland	Oregon	97210	Recruiting
University of Pennsylvania	Philadelphia	Pennsylvania	19104	Recruiting
University of Pittsburgh Medical Center (UPMC) Hillman Cancer Center	Pittsburgh	Pennsylvania	15232	Recruiting
University of Tennessee Medical Center	Knoxville	Tennessee	37920	Recruiting
Henry-Joyce Cancer Clinic	Nashville	Tennessee	37232	Recruiting
Texas Oncology- Baylor Charles A. Sammons Cancer Center	Dallas	Texas	75264	Recruiting
Huntsman Cancer Institute, University of Utah	Salt Lake City	Utah	84112	Recruiting
University of Virginia	Charlottesville	Virginia	22903	Recruiting
Virginia Cancer Specialists - Fairfax Office	Fairfax	Virginia	22031	Recruiting
Fred Hutchinson Cancer Center	Seattle	Washington	98109	Recruiting
Froedtert Hospital and the Medical College of Wisconsin	Milwaukee	Wisconsin	53226	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 84 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT06943755, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Aug 25, 2026 · Synced Sep 2, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT06943755 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →