ClinicalTrials.gov record
A Study to Compare Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) Versus Pembrolizumab Alone as Treatment in Participants With Mismatch Repair Proficient Endometrial Cancer (MK-2870-033/TroFuse-033/GOG-3119/ENGOT-en29)
ClinicalTrials.gov ID: NCT06952504
Public ClinicalTrials.gov record NCT06952504. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced May 10, 2026, 9:42 AM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3 Randomized, Open-label, Multicenter Study to Compare the Efficacy and Safety of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) in Combination With Pembrolizumab Versus Pembrolizumab Alone as First-line Maintenance Treatment in Participants With Mismatch Repair Proficient Endometrial Cancer (TroFuse-033/GOG-3119/ENGOT-en29)
Study identification
- NCT ID
- NCT06952504
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Merck Sharp & Dohme LLC
- Industry
- Enrollment
- 1,123 participants
Conditions and interventions
Conditions
Interventions
- Carboplatin Drug
- Docetaxel Drug
- Paclitaxel Drug
- Pembrolizumab Biological
- Sacituzumab Tirumotecan Biological
Drug · Biological
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- Female
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 21, 2025
- Primary completion
- May 23, 2032
- Completion
- May 23, 2032
- Last update posted
- May 7, 2026
2025 – 2032
United States locations
- U.S. sites
- 44
- U.S. states
- 25
- U.S. cities
- 43
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of South Alabama, Mitchell Cancer Institute ( Site 6033) | Mobile | Alabama | 36604 | Recruiting |
| Alaska Women's Cancer Care ( Site 6036) | Anchorage | Alaska | 99508 | Recruiting |
| University of California, Irvine (UCI) Health - UC Irvine Medical Center ( Site 6020) | Orange | California | 92868 | Recruiting |
| John Muir Health Cancer Center ( Site 6028) | Walnut Creek | California | 94598 | Recruiting |
| Yale University School of Medicine ( Site 6009) | New Haven | Connecticut | 06510 | Recruiting |
| MedStar Washington Hospital Center ( Site 5005) | Washington D.C. | District of Columbia | 20010 | Recruiting |
| Florida Cancer Specialists - South ( Site 7003) | Fort Myers | Florida | 33901 | Recruiting |
| UF Health Davis Cancer Pavilion and Shands Med Plaza ( Site 6026) | Gainesville | Florida | 32608 | Recruiting |
| Mount Sinai Cancer Center ( Site 6031) | Miami Beach | Florida | 33140 | Recruiting |
| AdventHealth Orlando-AdventHealth Medical Group Gynecological Oncology ( Site 6002) | Orlando | Florida | 32804 | Recruiting |
| Florida Cancer Specialists ( Site 7002) | St. Petersburg | Florida | 33701 | Recruiting |
| Florida Cancer Specialists East ( Site 7001) | West Palm Beach | Florida | 33401 | Recruiting |
| St. Joseph's/Candler Health System ( Site 6021) | Savannah | Georgia | 31405 | Recruiting |
| University of Chicago Medical Center ( Site 5002) | Chicago | Illinois | 60637 | Recruiting |
| Parkview Research Center ( Site 6008) | Fort Wayne | Indiana | 46845 | Recruiting |
| Women's Cancer Care ( Site 6010) | Covington | Louisiana | 70433 | Recruiting |
| TRIALS 365 ( Site 6005) | Shreveport | Louisiana | 71103 | Recruiting |
| Maine Medical Center - Scarborough Campus ( Site 6042) | Scarborough | Maine | 04074 | Recruiting |
| Tufts Medical Center ( Site 6052) | Boston | Massachusetts | 02111 | Recruiting |
| Minnesota Oncology Hematology, PA ( Site 8003) | Minneapolis | Minnesota | 55404 | Recruiting |
| St. Dominic's Hospital ( Site 5004) | Jackson | Mississippi | 39216 | Recruiting |
| Holy Name Medical Center ( Site 6011) | Teaneck | New Jersey | 07666 | Recruiting |
| University of New Mexico Comprehensive Cancer Center ( Site 6046) | Albuquerque | New Mexico | 87131 | Recruiting |
| Perlmutter Cancer Center at NYU Langone Hospital - Long Island ( Site 6055) | Mineola | New York | 11501 | Recruiting |
| Laura and Isaac Perlmutter Cancer Center at NYU Langone ( Site 6004) | New York | New York | 10016 | Recruiting |
| Duke Cancer Institute ( Site 6049) | Durham | North Carolina | 27710 | Recruiting |
| FirstHealth of the Carolinas ( Site 6037) | Pinehurst | North Carolina | 28374 | Recruiting |
| Miami Valley Hospital South ( Site 6014) | Centerville | Ohio | 45459 | Recruiting |
| The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive C ( Site 6007) | Columbus | Ohio | 43210 | Recruiting |
| Kettering Health Main Campus-Kettering Health Cancer Center ( Site 5001) | Kettering | Ohio | 45429 | Recruiting |
| Oklahoma Cancer Specialists and Research Institute, LLC ( Site 6047) | Tulsa | Oklahoma | 74146 | Recruiting |
| Oncology Associates of Oregon, P.C. ( Site 8005) | Eugene | Oregon | 97401 | Recruiting |
| St. Luke's University Health Network ( Site 6041) | Bethlehem | Pennsylvania | 18015 | Recruiting |
| Hospital of the University of Pennsylvania ( Site 5007) | Philadelphia | Pennsylvania | 19104 | Recruiting |
| Hospital of the University of Pennsylvania ( Site 6023) | Philadelphia | Pennsylvania | 19104 | Completed |
| AHN West Penn Hospital ( Site 6006) | Pittsburgh | Pennsylvania | 15224 | Recruiting |
| Women & Infants Hospital ( Site 5003) | Providence | Rhode Island | 02905 | Recruiting |
| Texas Oncology - DFW ( Site 8004) | Fort Worth | Texas | 76104 | Recruiting |
| Houston Methodist Hospital ( Site 6057) | Houston | Texas | 77030 | Recruiting |
| Texas Oncology-San Antonio Medical Center ( Site 8001) | San Antonio | Texas | 78240 | Recruiting |
| Texas Oncology - Northeast Texas ( Site 8002) | Tyler | Texas | 75702 | Recruiting |
| Texas Oncology - Gulf Coast ( Site 8006) | Webster | Texas | 77598 | Recruiting |
| Inova Schar Cancer Institute ( Site 6003) | Fairfax | Virginia | 22031 | Recruiting |
| VCU Health Adult Outpatient Pavillion ( Site 5000) | Richmond | Virginia | 23219 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 204 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06952504, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 7, 2026 · Synced May 10, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06952504 live on ClinicalTrials.gov.